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ERCC3 excision repair cross-complementation group 3 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000122 Homo sapiens excision repair cross-complementation group 3 (ERCC3), mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005263618 PREDICTED: Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 3 (ERCC3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol ERCC3
Entrez Gene ID 2071
Full Name excision repair cross-complementation group 3
Synonyms BTF2, GTF2H, RAD25, TFIIH, XPB
General protein information
Preferred Names
TFIIH basal transcription factor complex helicase XPB subunit
TFIIH basal transcription factor complex helicase XPB subunit
BTF2 p89
TFIIH 89 kDa subunit
DNA excision repair protein ERCC-3
DNA repair protein complementing XP-B cells
basic transcription factor 2 89 kDa subunit
xeroderma pigmentosum, complementation group B
xeroderma pigmentosum group B-complementing protein
TFIIH basal transcription factor complex 89 kDa subunit
Gene Type protein-coding
Organism Homo sapiens (human)



Summary ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq, Jul 2008].

MIM: 133510

Xeroderma pigmentosum, group B, 610651 (3); Trichothiodystrophy,

mRNA Protein Product Sequence Price Select
NM_000122, 4557562 NP_000113, 4557563 TFIIH basal transcription factor complex helicase XPB subunit ORF Sequence $750.00
XM_005263618, 530369092 XP_005263675, 530369093 TFIIH basal transcription factor complex helicase XPB subunit isoform X1 ORF Sequence $700.00
hsa03022Basal transcription factors
hsa03420Nucleotide excision repair
hsa_M00290Holo-TFIIH complex
WP405Eukaryotic Transcription Initiation
REACT_216DNA Repair
REACT_1826Nucleotide Excision Repair
REACT_311Dual incision reaction in GG-NER
REACT_1628Transcription-coupled NER (TC-NER)
REACT_71Gene Expression
REACT_1941Formation of transcription-coupled NER (TC-NER) repair complex
REACT_2089RNA Polymerase II Promoter Escape
REACT_2253Global Genomic NER (GG-NER)
REACT_257Formation of incision complex in GG-NER
REACT_1655RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REACT_1851RNA Polymerase II Transcription Initiation
REACT_1845Formation of RNA Pol II elongation complex
REACT_2222Dual incision reaction in TC-NER
REACT_834RNA Polymerase II Transcription Initiation And Promoter Clearance
REACT_846Formation of the Early Elongation Complex
REACT_6185HIV Infection
REACT_6256HIV Life Cycle
REACT_6274HIV Transcription Elongation
REACT_6346Formation of HIV-1 elongation complex containing HIV-1 Tat
REACT_6237RNA Pol II CTD phosphorylation and interaction with CE
REACT_6253RNA Polymerase II HIV Promoter Escape
REACT_6319Formation of the HIV-1 Early Elongation Complex
REACT_833RNA Polymerase II Transcription Elongation
REACT_1470mRNA Capping
REACT_6162Tat-mediated elongation of the HIV-1 transcript
REACT_6361Late Phase of HIV Life Cycle
REACT_6233Transcription of the HIV genome
REACT_6332HIV Transcription Initiation
REACT_1974RNA Polymerase I Promoter Clearance
REACT_2204RNA Polymerase I Chain Elongation
REACT_1913RNA Polymerase I Promoter Escape
REACT_1366RNA Polymerase II Transcription
REACT_1074RNA Polymerase I Transcription Termination
REACT_975RNA Pol II CTD phosphorylation and interaction with CE
REACT_953RNA Polymerase I Transcription Initiation
REACT_1309RNA Polymerase I Transcription
REACT_22107RNA Polymerase II Pre-transcription Events
REACT_21352RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
REACT_22201Formation of HIV elongation complex in the absence of HIV Tat
REACT_200857Epigenetic regulation of gene expression
REACT_200834Negative epigenetic regulation of rRNA expression
REACT_200856NoRC negatively regulates rRNA expression
Homo sapiens (human)ERCC3NP_000113.1
Pan troglodytes (chimpanzee)ERCC3XP_525907.3
Macaca mulatta (Rhesus monkey)ERCC3XP_001086722.1
Canis lupus familiaris (dog)ERCC3XP_533314.2
Bos taurus (cattle)ERCC3NP_001039453.1
Mus musculus (house mouse)Ercc3NP_598419.1
Rattus norvegicus (Norway rat)Ercc3NP_001026814.1
Gallus gallus (chicken)ERCC3NP_001006523.1
Danio rerio (zebrafish)ercc3NP_963876.1
Drosophila melanogaster (fruit fly)hayNP_524020.2
Caenorhabditis elegansY66D12A.15NP_499487.1
Arabidopsis thaliana (thale cress)XPB1NP_568592.1
Arabidopsis thaliana (thale cress)XPB2NP_568591.1
Xenopus (Silurana) tropicalis (western clawed frog)ercc3NP_001123812.1
GO:0000717nucleotide-excision repair, DNA duplex unwindingIMP
GO:0000718nucleotide-excision repair, DNA damage removalTAS
GO:0001666response to hypoxiaIEA
GO:0006200ATP catabolic processIEA
GO:0006265DNA topological changeIMP
GO:0006281DNA repairIMP
GO:0006281DNA repairTAS
GO:0006283transcription-coupled nucleotide-excision repairIDA
GO:0006283transcription-coupled nucleotide-excision repairTAS
GO:0006289nucleotide-excision repairIMP
GO:0006289nucleotide-excision repairTAS
GO:0006360transcription from RNA polymerase I promoterTAS
GO:0006361transcription initiation from RNA polymerase I promoterTAS
GO:0006362transcription elongation from RNA polymerase I promoterTAS
GO:0006363termination of RNA polymerase I transcriptionTAS
GO:0006366transcription from RNA polymerase II promoterIDA
GO:0006366transcription from RNA polymerase II promoterIMP
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0006368transcription elongation from RNA polymerase II promoterTAS
GO:00063707-methylguanosine mRNA cappingTAS
GO:0006468protein phosphorylationIEA
GO:0006915apoptotic processIMP
GO:0006979response to oxidative stressIMP
GO:0008104protein localizationIMP
GO:0009411response to UVIMP
GO:0009650UV protectionIEA
GO:0010467gene expressionTAS
GO:0016032viral processTAS
GO:0033683nucleotide-excision repair, DNA incisionIMP
GO:0035315hair cell differentiationIMP
GO:0043065positive regulation of apoptotic processIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0050434positive regulation of viral transcriptionTAS
GO:1901990regulation of mitotic cell cycle phase transitionIMP
GO:0005675holo TFIIH complexIDA
GO:0005675holo TFIIH complexTAS
GO:0003677DNA bindingTAS
GO:0003684damaged DNA bindingNAS
GO:0004003ATP-dependent DNA helicase activityIEA
GO:0004672protein kinase activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0005525GTP bindingIEA
GO:0008022protein C-terminus bindingIPI
GO:0008094DNA-dependent ATPase activityIDA
GO:0008094DNA-dependent ATPase activityIMP
GO:0008134transcription factor bindingIDA
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityIDA
GO:0016887ATPase activityIDA
GO:0032564dATP bindingIEA
GO:0042277peptide bindingIEA
GO:00431383'-5' DNA helicase activityIDA
GO:00431383'-5' DNA helicase activityIMP
GO:0047485protein N-terminus bindingIPI
GeneCards ERCC3
UniProt G3V1S1, P19447
Vega OTTHUMG00000131530
MIM 133510
Ensembl ENSG00000163161
HGNC 3435
HPRD 00593

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ERCC3 gene?

The ERCC3 gene provides instructions for making a protein called XPB. This protein is an essential part (subunit) of a group of proteins known as the general transcription factor IIH (TFIIH) complex. The TFIIH complex has two major functions: it is involved in a process called gene transcription, and it helps repair damaged DNA.

Gene transcription is the first step in protein production. By controlling gene transcription, the TFIIH complex helps regulate the activity of many different genes. Studies suggest that the XPB protein works together with XPD, another protein in the TFIIH complex that is produced from the ERCC2 gene, to start (initiate) gene transcription.

The TFIIH complex also plays an important role in repairing damaged DNA. DNA can be damaged by ultraviolet (UV) rays from the sun and by toxic chemicals, radiation, and unstable molecules called free radicals. DNA damage occurs frequently, but normal cells are usually able to fix it before it can cause problems. One of the major mechanisms that cells use to fix DNA is known as nucleotide excision repair (NER). As part of this repair mechanism, the TFIIH complex unwinds the section of double-stranded DNA that surrounds the damage. Studies suggest that the XPB protein may act as a wedge, holding open the two strands of DNA so other proteins can snip out (excise) the abnormal section and replace the damaged area with the correct DNA.


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