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Sequence in raw or FASTA format:

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ERCC5 excision repair cross-complementation group 5 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20331 NM_000123 Homo sapiens excision repair cross-complementation group 5 (ERCC5), mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu20331C NM_000123 Homo sapiens excision repair cross-complementation group 5 (ERCC5), mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol ERCC5
Entrez Gene ID 2073
Full Name excision repair cross-complementation group 5
Synonyms COFS3, ERCM2, UVDR, XPG, XPGC
General protein information
Preferred Names
DNA repair protein complementing XP-G cells
Names
DNA repair protein complementing XP-G cells
XPG-complementing protein
DNA excision repair protein ERCC-5
xeroderma pigmentosum, complementation group G
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q33

Summary This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011].
Disorder

MIM: 133530

Xeroderma pigmentosum, group G, 278780 (3); Cerebrooculofacioskeletal

mRNA Protein Product Sequence Price Select
NM_000123, 324715039 NP_000114, 51988900 DNA repair protein complementing XP-G cells ORF Sequence $1500.00
KEGG
hsa03420Nucleotide excision repair
Reactome
REACT_216DNA Repair
REACT_1826Nucleotide Excision Repair
REACT_311Dual incision reaction in GG-NER
REACT_1628Transcription-coupled NER (TC-NER)
REACT_1941Formation of transcription-coupled NER (TC-NER) repair complex
REACT_2253Global Genomic NER (GG-NER)
REACT_257Formation of incision complex in GG-NER
REACT_2222Dual incision reaction in TC-NER
Homo sapiens (human)ERCC5NP_000114.2
Pan troglodytes (chimpanzee)ERCC5XP_003314253.1
Macaca mulatta (Rhesus monkey)ERCC5XP_001096257.2
Canis lupus familiaris (dog)ERCC5XP_003639860.1
Bos taurus (cattle)ERCC5NP_001030353.1
Mus musculus (house mouse)Ercc5NP_035859.2
Rattus norvegicus (Norway rat)Ercc5XP_006244951.1
Gallus gallus (chicken)ERCC5NP_001029995.1
Process
IDNameEvidence
GO:0000718nucleotide-excision repair, DNA damage removalTAS
GO:0000737DNA catabolic process, endonucleolyticIDA
GO:0006281DNA repairTAS
GO:0006283transcription-coupled nucleotide-excision repairIMP
GO:0006283transcription-coupled nucleotide-excision repairTAS
GO:0006289nucleotide-excision repairTAS
GO:0006295nucleotide-excision repair, DNA incision, 3'-to lesionIDA
GO:0006295nucleotide-excision repair, DNA incision, 3'-to lesionIMP
GO:0009411response to UVIDA
GO:0009411response to UVIMP
GO:0009650UV protectionIGI
GO:0010225response to UV-CIMP
GO:0043066negative regulation of apoptotic processIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005662DNA replication factor A complexIDA
GO:0005675holo TFIIH complexIDA
GO:0005730nucleolusIDA
GO:0016591DNA-directed RNA polymerase II, holoenzymeIDA
GO:0045111intermediate filament cytoskeletonIDA
Function
IDNameEvidence
GO:0000405bubble DNA bindingIDA
GO:0003690double-stranded DNA bindingIDA
GO:0003697single-stranded DNA bindingIDA
GO:0004519endonuclease activityTAS
GO:0004520endodeoxyribonuclease activityIDA
GO:0005515protein bindingIPI
GO:0042803protein homodimerization activityIPI
GO:0046872metal ion bindingIEA
GO:0047485protein N-terminus bindingIPI
GeneCards ERCC5
UniProt P28715
Vega OTTHUMG00000017310
MIM 133530
Ensembl ENSG00000134899
HGNC 3437
HPRD 00595

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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