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ESR2 estrogen receptor 2 (ER beta) [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_001437 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant a, mRNA. Full Length $629.01
ORF Sequence $461.97
NM_001040275 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant b, mRNA. Full Length $716.30
ORF Sequence $431.52
NM_001040276 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant c, mRNA. Full Length $796.05
ORF Sequence $431.52


Gene Symbol ESR2
Entrez Gene ID 2100
Full Name estrogen receptor 2 (ER beta)
Synonyms ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q23.2
Summary This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq].
Disorder

MIM: 601663
mRNA NM_001437, 94538323
Protein NP_001428, 10835013
Product estrogen receptor beta isoform 1
RefSeq Status REVIEWED
mRNA NM_001040275, 94538324
Protein NP_001035365, 94538325
Product estrogen receptor beta isoform 2
RefSeq Status REVIEWED
mRNA NM_001040276, 94538327
Protein NP_001035366, 94538328
Product estrogen receptor beta isoform 2
RefSeq Status REVIEWED
Pathway Interaction Database
er_nongenomic_pathwayPlasma membrane estrogen receptor signaling
WikiPathways
WP706SIDS Susceptibility Pathways
WP34Ovarian Infertility Genes
WP138Androgen Receptor Signaling Pathway
WP170Nuclear Receptors
Reactome
REACT_15525Nuclear Receptor transcription pathway
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
Homo sapiens (human)ESR2NP_001428.1
Pan troglodytes (chimpanzee)ESR2XP_001170268.1
Canis lupus familiaris (dog)ESR2XP_866098.1
Bos taurus (cattle)ESR2NP_776476.1
Mus musculus (house mouse)Esr2NP_997590.1
Rattus norvegicus (Norway rat)Esr2NP_036886.1
Gallus gallus (chicken)ESR2NP_990125.1
Danio rerio (zebrafish)esr2aNP_851297.1
Danio rerio (zebrafish)esr2bNP_777287.2
Process
IDNameEvidence
GO:0001541ovarian follicle developmentIEA
GO:0001662behavioral fear responseIEA
GO:0001764neuron migrationIEA
GO:0006351transcription, DNA-dependentTAS
GO:0006355regulation of transcription, DNA-dependentTAS
GO:0007165signal transductionTAS
GO:0007267cell-cell signalingTAS
GO:0007420brain developmentIEA
GO:0007611learning or memoryIEA
GO:0009968negative regulation of signal transductionNAS
GO:0010467gene expressionTAS
GO:0030308negative regulation of cell growthNAS
GO:0030520estrogen receptor signaling pathwayTAS
GO:0033574response to testosterone stimulusIEA
GO:0034339regulation of transcription from RNA polymerase II promoter by nuclear hormone receptorTAS
GO:0043065positive regulation of apoptosisIEA
GO:0043401steroid hormone mediated signaling pathwayTAS
GO:0043526neuroprotectionIEA
GO:0045885positive regulation of survival gene product expressionIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0048521negative regulation of behaviorIEA
GO:0050680negative regulation of epithelial cell proliferationIEA
GO:0060065uterus developmentIEA
GO:0060068vagina developmentIEA
GO:0060740prostate gland epithelium morphogenesisIEA
GO:0060743epithelial cell maturation involved in prostate gland developmentIEA
GO:0060766negative regulation of androgen receptor signaling pathwayIEA
Component
IDNameEvidence
GO:0005634nucleusTAS
GO:0005654nucleoplasmTAS
GO:0005737cytoplasmIEA
GO:0005739mitochondrionIDA
GO:0043005neuron projectionIEA
GO:0043204perikaryonIEA
Function
IDNameEvidence
GO:0003677DNA bindingTAS
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0003707steroid hormone receptor activityTAS
GO:0003713transcription coactivator activityTAS
GO:0004879ligand-dependent nuclear receptor activityNAS
GO:0005496steroid bindingTAS
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GO:0019899enzyme bindingIPI
GO:0030284estrogen receptor activityTAS
GO:0042562hormone bindingIEA
GO:0043565sequence-specific DNA bindingIEA
GO:0046872metal ion bindingIEA
GO:0048019receptor antagonist activityNAS
GeneCards ESR2
PDB 2I0G, 1L2J, 2FSZ, 3OLL, 1X7B, 2NV7, 2GIU, 1NDE, 1X76, 2JJ3, 1YY4, 1U3S, 1X78, 1QKM, 1U3R, 1ZAF, 1X7J, 1U9E, 2QTU, 3OLS, 1YYE, 2Z4B, 1U3Q
UniProt Q92731, Q7LCB3
MIM 601663
Ensembl ENSG00000140009
HGNC 3468
HPRD 03390

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