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Sequence in raw or FASTA format:

Database:

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ESR2 estrogen receptor 2 (ER beta) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22338 NM_001214902 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant d, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu22461 NM_001271876 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant f, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu23139 NM_001271877 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant g, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu23506 NM_001291712 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant k, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu23506 NM_001291723 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant l, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu23506 NM_001040275 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant b, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu25562 NM_001437 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant a, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu23506 XM_006720076 PREDICTED: Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu22338C NM_001214902 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant d, mRNA. Customized vector On-demand 7-9 $269.00
OHu22461C NM_001271876 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant f, mRNA. Customized vector On-demand 7-9 $269.00
OHu23139C NM_001271877 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant g, mRNA. Customized vector On-demand 7-9 $269.00
OHu23506C NM_001291712 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant k, mRNA. Customized vector On-demand 7-9 $269.00
OHu23506C NM_001291723 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant l, mRNA. Customized vector On-demand 7-9 $269.00
OHu23506C NM_001040275 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant b, mRNA. Customized vector In-stock 5-7 $149.00
OHu25562C NM_001437 Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant a, mRNA. Customized vector On-demand 7-9 $269.00
OHu23506C XM_006720076 PREDICTED: Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

*Business Day

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Gene Symbol ESR2
Entrez Gene ID 2100
Full Name estrogen receptor 2 (ER beta)
Synonyms ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
General protein information
Preferred Names
estrogen receptor beta
Names
estrogen receptor beta
estrogen receptor beta 4
estrogen nuclear receptor beta variant a
estrogen nuclear receptor beta variant b
nuclear receptor subfamily 3 group A member 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q23.2

Summary This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601663

mRNA Protein Product Sequence Price Select
NM_001040275, 94538324 NP_001035365, 94538325 estrogen receptor beta isoform 2 ORF Sequence $360.00
NM_001214902, 333609292 NP_001201831, 333609293 estrogen receptor beta isoform 3 ORF Sequence $550.00
NM_001271876, 428673530 NP_001258805, 428673531 estrogen receptor beta isoform 5 ORF Sequence $550.00
NM_001271877, 428673532 NP_001258806, 428673533 estrogen receptor beta isoform 6 ORF Sequence $550.00
NM_001291712, 619328972 NP_001278641, 619328973 estrogen receptor beta isoform 2 ORF Sequence $550.00
NM_001291723, 619328992 NP_001278652, 619328993 estrogen receptor beta isoform 2 ORF Sequence $550.00
NM_001437, 94538323 NP_001428, 10835013 estrogen receptor beta isoform 1 ORF Sequence $550.00
XM_006720076, 578825589 XP_006720139, 578825590 estrogen receptor beta isoform X2 ORF Sequence $550.00
KEGG
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
WikiPathways
WP34Ovarian Infertility Genes
WP170Nuclear Receptors
WP706SIDS Susceptibility Pathways
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
er_nongenomic_pathwayPlasma membrane estrogen receptor signaling
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_15525Nuclear Receptor transcription pathway
Homo sapiens (human)ESR2NP_001428.1
Pan troglodytes (chimpanzee)ESR2XP_001170310.1
Macaca mulatta (Rhesus monkey)ESR2XP_001101433.1
Canis lupus familiaris (dog)ESR2XP_866134.3
Bos taurus (cattle)ESR2NP_776476.2
Mus musculus (house mouse)Esr2NP_034287.3
Rattus norvegicus (Norway rat)Esr2NP_036886.1
Gallus gallus (chicken)ESR2NP_990125.1
Danio rerio (zebrafish)esr2aNP_851297.1
Danio rerio (zebrafish)esr2bNP_777287.2
Xenopus (Silurana) tropicalis (western clawed frog)esr2NP_001035101.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0001541ovarian follicle developmentIEA
GO:0001764neuron migrationIEA
GO:0006355regulation of transcription, DNA-templatedTAS
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0007165signal transductionTAS
GO:0007267cell-cell signalingTAS
GO:0007420brain developmentIEA
GO:0008628hormone-mediated apoptotic signaling pathwayIEA
GO:0010467gene expressionTAS
GO:0030308negative regulation of cell growthNAS
GO:0030520intracellular estrogen receptor signaling pathwayTAS
GO:0043401steroid hormone mediated signaling pathwayIEA
GO:0050680negative regulation of epithelial cell proliferationIEA
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIDA
GO:0060065uterus developmentIEA
GO:0060068vagina developmentIEA
GO:0060740prostate gland epithelium morphogenesisIEA
GO:0060743epithelial cell maturation involved in prostate gland developmentIEA
GO:0060766negative regulation of androgen receptor signaling pathwayIEA
GO:1900116extracellular negative regulation of signal transductionNAS
Component
IDNameEvidence
GO:0005576extracellular regionNAS
GO:0005634nucleusIDA
GO:0005634nucleusTAS
GO:0005654nucleoplasmTAS
GO:0005739mitochondrionIDA
Function
IDNameEvidence
GO:0001046core promoter sequence-specific DNA bindingIDA
GO:0003677DNA bindingTAS
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0003707steroid hormone receptor activityTAS
GO:0003713transcription coactivator activityTAS
GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIDA
GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityNAS
GO:0005496steroid bindingISS
GO:0005496steroid bindingTAS
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GO:0019899enzyme bindingIPI
GO:0030284estrogen receptor activityTAS
GO:0034056estrogen response element bindingIDA
GO:0048019receptor antagonist activityNAS
GeneCards ESR2
UniProt F1D8N3, G3V5M5, Q92731, Q7LCB3, Q0PTK2
Vega OTTHUMG00000141306
MIM 601663
Ensembl ENSG00000140009
HGNC 3468
HPRD 03390

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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