ALB albumin [Homo sapiens (human)]

Gene Symbol	ALB
Entrez Gene ID	213
Full Name	albumin
Synonyms	DKFZp779N1935, PRO0883, PRO0903, PRO1341
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:4 Map Location:4q13.3
Summary	Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq].
Disorder	MIM: 103600 Analbuminemia (3); [Dysalbuminemic hyperthyroxinemia] (3);

mRNA	NM_000477, 215982788
Protein	NP_000468, 4502027
Product	serum albumin preproprotein
RefSeq Status	REVIEWED

Pathway Interaction Database

hnf3bpathway

FOXA2 and FOXA3 transcription factor networks

WikiPathways

WP15	Selenium Pathway

Reactome

REACT_22285	Transport of vitamins, nucleosides, and related molecules
REACT_318	Platelet degranulation
REACT_604	Hemostasis
REACT_22258	Metabolism of lipids and lipoproteins
REACT_11040	Bile acid and bile salt metabolism
REACT_11042	Recycling of bile acids and salts
REACT_23988	Transport of organic anions
REACT_13621	HDL-mediated lipid transport
REACT_20	Formation of Platelet plug
REACT_15518	Transmembrane transport of small molecules
REACT_602	Lipid digestion, mobilization, and transport
REACT_6823	Lipoprotein metabolism
REACT_19118	SLC-mediated transmembrane transport
REACT_798	Platelet Activation
REACT_1280	Response to elevated platelet cytosolic Ca2+

Homo sapiens (human)	ALB	NP_000468.1
Pan troglodytes (chimpanzee)	ALB	XP_517233.2
Canis lupus familiaris (dog)	ALB	XP_855557.1
Bos taurus (cattle)	ALB	NP_851335.1
Mus musculus (house mouse)	Alb	NP_033784.1
Rattus norvegicus (Norway rat)	Alb	NP_599153.1
Gallus gallus (chicken)	ALB	NP_990592.1

Process

ID	Name	Evidence
GO:0002576	platelet degranulation	TAS
GO:0006629	lipid metabolic process	TAS
GO:0006810	transport	TAS
GO:0006950	response to stress	IEA
GO:0007584	response to nutrient	IEA
GO:0007596	blood coagulation	TAS
GO:0008206	bile acid metabolic process	TAS
GO:0009267	cellular response to starvation	IDA
GO:0010033	response to organic substance	IEA
GO:0015721	bile acid and bile salt transport	TAS
GO:0019836	hemolysis by symbiont of host erythrocytes	IDA
GO:0030168	platelet activation	TAS
GO:0042157	lipoprotein metabolic process	TAS
GO:0043066	negative regulation of apoptosis	IDA
GO:0043069	negative regulation of programmed cell death	NAS
GO:0043252	sodium-independent organic anion transport	EXP
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	IEA
GO:0046689	response to mercury ion	IEA
GO:0051659	maintenance of mitochondrion location	IDA
GO:0055085	transmembrane transport	TAS
GO:0070541	response to platinum ion	IEA

Component

ID	Name	Evidence
GO:0005576	extracellular region	EXP
GO:0005576	extracellular region	NAS
GO:0005576	extracellular region	TAS
GO:0005604	basement membrane	IEA
GO:0005615	extracellular space	IDA
GO:0005737	cytoplasm	IEA
GO:0031093	platelet alpha granule lumen	TAS
GO:0043234	protein complex	IDA

Function

ID	Name	Evidence
GO:0003677	DNA binding	IDA
GO:0005504	fatty acid binding	IDA
GO:0005504	fatty acid binding	NAS
GO:0005507	copper ion binding	NAS
GO:0005515	protein binding	IPI
GO:0008144	drug binding	IDA
GO:0008144	drug binding	NAS
GO:0008270	zinc ion binding	IEA
GO:0015643	toxin binding	IDA
GO:0016209	antioxidant activity	NAS
GO:0019825	oxygen binding	IDA
GO:0030170	pyridoxal phosphate binding	IDA
GO:0043498	cell surface binding	IEA
GO:0046872	metal ion binding	IEA
GO:0051087	chaperone binding	IPI

GeneCards	ALB
PDB	2BXQ, 1HK4, 3LU7, 2BXK, 1UOR, 1E7B, 1HK2, 1HK5, 2XVQ, 2BXO, 1YSX, 3JRY, 2BXN, 2BXE, 1AO6, 1GNJ, 2XW0, 2XVW, 2BXL, 1GNI, 3A73, 1BJ5, 3CX9, 2BXP, 2BXD, 2BXM, 2VUE, 2BXI, 2XVU, 2VUF, 3B9L, 2I30, 2XVV, 1O9X, 1BKE, 1HK1, 1H9Z, 2I2Z, 2ESG, 1E7E, 2BXG, 2BXH, 2BXF, 3B9M, 1E7G, 2BXC, 1TF0, 1E7C, 3LU6, 1E7H, 2BXA, 1HK3, 2XSI, 2BXB, 1E7I, 2XW1, 3JQZ, 1HA2, 1E7A, 1BM0, 1E78, 2VDB, 1N5U, 1E7F, 2BX8, 3LU8
UniProt	P02768
MIM	103600
Ensembl	ENSG00000163631
HGNC	399
HPRD	00062

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RefSeq Accession	Definition	Sequence	Price	Select
NM_000477	Homo sapiens albumin (ALB), mRNA.	Full Length	$656.56
NM_000477	Homo sapiens albumin (ALB), mRNA.	ORF Sequence	$530.70