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EWSR1 Ewing sarcoma breakpoint region 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001163285 Homo sapiens Ewing sarcoma breakpoint region 1 (EWSR1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001163286 Homo sapiens Ewing sarcoma breakpoint region 1 (EWSR1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001163287 Homo sapiens Ewing sarcoma breakpoint region 1 (EWSR1), transcript variant 5, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_005243 Homo sapiens Ewing sarcoma breakpoint region 1 (EWSR1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_013986 Homo sapiens Ewing sarcoma breakpoint region 1 (EWSR1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol EWSR1
Entrez Gene ID 2130
Full Name Ewing sarcoma breakpoint region 1
Synonyms EWS, bK984G1.4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q12.2

Summary This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009].
Disorder

MIM: 133450

Ewing sarcoma, 612219 (3); Neuroepithelioma, 612219 (3)

mRNA Protein Product Sequence Price Select
NM_001163285, 253970501 NP_001156757, 253970502 RNA-binding protein EWS isoform 3 ORF Sequence $700.00
NM_001163286, 253970503 NP_001156758, 253970504 RNA-binding protein EWS isoform 4 ORF Sequence $700.00
NM_001163287, 253970505 NP_001156759, 253970506 RNA-binding protein EWS isoform 5 ORF Sequence $269.00
NM_005243, 253970497 NP_005234, 4885225 RNA-binding protein EWS isoform 2 ORF Sequence $490.00
NM_013986, 253970499 NP_053733, 253970500 RNA-binding protein EWS isoform 1 ORF Sequence $700.00
KEGG
hsa05202Transcriptional misregulation in cancer
Pathway Interaction Database
bard1pathwayBARD1 signaling events
Homo sapiens (human)EWSR1NP_053733.2
Pan troglodytes (chimpanzee)EWSR1XP_001173113.2
Macaca mulatta (Rhesus monkey)EWSR1XP_001104497.1
Canis lupus familiaris (dog)EWSR1XP_003433443.1
Bos taurus (cattle)EWSR1NP_001103270.1
Mus musculus (house mouse)Ewsr1NP_031994.2
Rattus norvegicus (Norway rat)Ewsr1NP_001020803.2
Gallus gallus (chicken)EWSR1NP_001034356.1
Danio rerio (zebrafish)ewsr1aNP_001108610.1
GeneCards EWSR1
PDB 2CPE
UniProt Q01844
MIM 133450
Ensembl ENSG00000182944
HGNC 3508
HPRD 00592

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
RNA-binding protein EWS
Names
RNA-binding protein EWS
Ewing sarcoma breakpoint region 1
Ewings sarcoma EWS-Fli1 (type 1) oncogene

Interactant



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