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F2 coagulation factor II (thrombin) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000506 Homo sapiens coagulation factor II (thrombin) (F2), mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

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Gene Symbol F2
Entrez Gene ID 2147
Full Name coagulation factor II (thrombin)
Synonyms PT, RPRGL2, THPH1
General protein information
Preferred Names
prothrombin
Names
prothrombin
serine protease
prothrombin B-chain
prepro-coagulation factor II
NP_000497.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p11

Summary Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008].
Disorder

MIM: 176930

Hypoprothrombinemia, 613679 (3); Dysprothrombinemia, 613679 (3);

mRNA Protein Product Sequence Price Select
NM_000506, 169808403 NP_000497, 4503635 prothrombin preproprotein ORF Sequence $700.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04810Regulation of actin cytoskeleton
hsa04610Complement and coagulation cascades
WikiPathways
WP15Selenium Pathway
WP272Blood Clotting Cascade
WP51Regulation of Actin Cytoskeleton
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
syndecan_4_pathwaySyndecan-4-mediated signaling events
Reactome
REACT_19184GPCR downstream signaling
REACT_15428Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
REACT_18283G alpha (q) signalling events
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_326Intrinsic Pathway
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_278Platelet Aggregation (Plug Formation)
REACT_1439Common Pathway
REACT_12051Cell surface interactions at the vascular wall
REACT_1906Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
REACT_733Removal of aminoterminal propeptides from gamma-carboxylated proteins
REACT_1050Gamma-carboxylation of protein precursors
REACT_17015Metabolism of proteins
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_1069PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
REACT_1132Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
REACT_21340GPCR ligand binding
REACT_22161Post-translational protein modification
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
REACT_111102Signal Transduction
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
Homo sapiens (human)F2NP_000497.1
Pan troglodytes (chimpanzee)F2XP_001165233.1
Macaca mulatta (Rhesus monkey)F2NP_001098055.1
Canis lupus familiaris (dog)F2XP_003639742.1
Bos taurus (cattle)F2NP_776302.1
Mus musculus (house mouse)F2NP_034298.1
Rattus norvegicus (Norway rat)F2NP_075213.2
Gallus gallus (chicken)F2NP_989936.1
Danio rerio (zebrafish)f2NP_998555.1
Xenopus (Silurana) tropicalis (western clawed frog)f2NP_001015797.1
Process
IDNameEvidence
GO:0001934positive regulation of protein phosphorylationIDA
GO:0006508proteolysisTAS
GO:0006953acute-phase responseIEA
GO:0007166cell surface receptor signaling pathwayIDA
GO:0007275multicellular organismal developmentTAS
GO:0007596blood coagulationTAS
GO:0007597blood coagulation, intrinsic pathwayTAS
GO:0008284positive regulation of cell proliferationIEA
GO:0008360regulation of cell shapeIEA
GO:0009611response to woundingIDA
GO:0010544negative regulation of platelet activationTAS
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIEA
GO:0017187peptidyl-glutamic acid carboxylationTAS
GO:0030168platelet activationIDA
GO:0030168platelet activationTAS
GO:0030193regulation of blood coagulationTAS
GO:0030194positive regulation of blood coagulationIDA
GO:0030307positive regulation of cell growthIEA
GO:0032967positive regulation of collagen biosynthetic processIDA
GO:0042730fibrinolysisIDA
GO:0043687post-translational protein modificationTAS
GO:0044267cellular protein metabolic processTAS
GO:0045861negative regulation of proteolysisIDA
GO:0048712negative regulation of astrocyte differentiationIDA
GO:0050900leukocyte migrationTAS
GO:0051281positive regulation of release of sequestered calcium ion into cytosolIDA
GO:0051480cytosolic calcium ion homeostasisIDA
GO:0051918negative regulation of fibrinolysisTAS
GO:1900738positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayIDA
GO:2000379positive regulation of reactive oxygen species metabolic processIDA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005788endoplasmic reticulum lumenTAS
GO:0005796Golgi lumenTAS
GO:0005886plasma membraneTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0004252serine-type endopeptidase activityIDA
GO:0005102receptor bindingIPI
GO:0005102receptor bindingIPI
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GO:0008083growth factor activityTAS
GO:0070053thrombospondin receptor activityIDA
GeneCards F2
PDB 3BIV, 2C8W, 1VZQ, 1C4U, 2ZO3, 1NY2, 2ZFR, 1K21, 1BCU, 1KTT, 1QJ6, 3QGN, 2C93, 2PW8, 2C90, 1DOJ, 1D3T, 1TOM, 1HAO, 4MLF, 1T4U, 2ZHW, 3RML, 2GP9, 1QHR, 1AD8, 1OYT, 1OOK, 2BVS, 1UVS, 4HFP, 1D3P, 2ZNK, 3JZ1, 1TA6, 2UUK, 2JH0, 1H8I, 3HKJ, 1THP, 3SHA, 1AY6, 2C8Z, 1HLT, 3RLY, 1PPB, 4LZ1, 3SI4, 3T5F, 1FPC, 1MU6, 4THN, 3QX5, 4HFY, 2BVR, 3BEI, 2PGQ, 2ANM, 3BV9, 1NZQ, 1BA8, 3P6Z, 2H9T, 1SHH, 3HAT, 1ZGV, 1EOJ, 3QTV, 3PO1, 1QJ1, 3EE0, 1D4P, 1EB1, 3P70, 2ZDV, 1UMA, 1SB1, 3UTU, 3K65, 3U69, 1DWD, 1YPK, 1NT1, 4BAH, 1AWF, 1JOU, 1ZGI, 3RMO, 1LHF, 3SQE, 4LZ4, 3C27, 4CH8, 3EGK, 2CF8, 1BMM, 7KME, 2ZF0, 1D6W, 1O5G, 1AE8, 1XM1, 1HXF, 1QJ7, 1HBT, 1IHT, 1O2G, 1VR1, 2JH5, 4O03, 3JZ2, 4DT7, 3NXP, 1WAY, 2R2M, 1BMN, 2B5T, 1GHY, 2A45, 2ZHE, 2BXU, 1C4Y, 1NRO, 4BAO, 1HAI, 3QWC, 4BAK, 2HGT, 1DM4, 2UUJ, 3U8T, 2V3H, 1YPJ, 1A4W, 1A61, 4AX9, 1TMB, 1NRR, 1YPG, 2ZFQ, 2JH6, 4HTC, 3DUX, 2HNT, 3BF6, 1NRN, 2V3O, 3D49, 4E7R, 1C5O, 4NZQ, 1A46, 3RM0, 1DWE, 3RMN, 2ZFF, 1NRS, 1GJ4, 1E0F, 3B9F, 3UWJ, 2PKS, 1JMO, 2ZHF, 4DII, 1SGI, 3EQ0, 1LHC, 3LDX, 3SV2, 1Z71, 1T4V, 8KME, 1G30, 1K22, 1HGT, 4E05, 1ABI, 1DE7, 3C1K, 1LHG, 1YPM, 3B23, 3RLW, 1HAH, 1IHS, 1NU9, 2ZIQ, 1D9I, 1TBZ, 1THR, 1MUE, 1THS, 4AYV, 1HAG, 2A0Q, 3VXF, 1B7X, 2OD3, 3U9A, 3SI3, 1GHW, 1MU8, 1TQ7, 4I7Y, 1TMT, 1CA8, 1HDT, 2C8Y, 3E6P, 1WBG, 2UUF, 1SFQ, 1SG8, 4BAN, 1GHX, 3S7K, 1BB0, 1AWH, 4N3L, 1EOL, 1QUR, 1G37, 2ANK, 1P8V, 2GDE, 4DIH, 2PGB, 1A5G, 1XMN, 4E06, 1HXE, 1YPE, 2BDY, 4AZ2, 1FPH, 2FES, 1BHX, 3DT0, 1MH0, 1Z8J, 3SHC, 2ZFP, 2BXT, 1A3E, 1C1U, 1C1W, 3RMM, 1RD3, 1DWB, 2THF, 4H6T, 3S7H, 1NO9, 1KTS, 3LU9, 3QLP, 3GIS, 2AFQ, 1C5L, 1GJ5, 1W7G, 3DA9, 2FEQ, 1HAP, 3GIC, 4BOH, 1TMU, 1ZRB, 1C4V, 1DIT, 3HTC, 3P17, 1BTH, 1AI8, 3SQH, 3TU7, 3PMH, 1B5G, 1D3Q, 3U8R, 3BIU, 1A2C, 1AHT, 1NRQ, 1G32, 4AYY, 2C8X, 1TQ0, 2ZGB, 3U98, 2ZC9, 4H6S, 1GHV, 4BAM, 4CH2, 3BEF, 4NZE, 3DHK, 1AIX, 4BAQ, 2ZGX, 1C5N, 1YPL, 1ABJ, 1LHD, 3VXE, 1RIW, 1Z8I, 3R3G, 1NRP, 1NU7, 1O0D, 2CN0, 1QBV, 1C1V, 4DY7, 1TB6, 3QDZ, 3DD2, 3U8O, 5GDS, 3QTO, 1A3B, 4HZH, 2A2X, 3RM2, 1TA2, 3F68, 1SR5, 1LHE, 1AFE, 2ZI2, 1SL3, 2HWL, 1JWT, 1DWC, 1TWX, 2CF9, 1NM6, 2ZDA, 2BVX, 1DX5, 2ZHQ, 1HUT, 1D3D, 2HPP, 2ZG0, 1H8D, 2HPQ
UniProt P00734
Vega OTTHUMG00000150344
MIM 176930
Ensembl ENSG00000180210
HGNC 3535
HPRD 01488

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the F2 gene?

The F2 gene provides instructions for making a protein called prothrombin (also called coagulation factor II). Coagulation factors are a group of related proteins that are essential for normal blood clotting (hemostasis). After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss.

Prothrombin is made chiefly by cells in the liver. The protein circulates in the bloodstream in an inactive form until an injury occurs that damages blood vessels. In response to injury, prothrombin is converted to its active form, thrombin. Thrombin then converts a protein called fibrinogen into fibrin, the primary protein that makes up blood clots.

Thrombin is also thought to be involved in cell growth and division (proliferation), tissue repair, and the formation of new blood vessels (angiogenesis).

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