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Sequence in raw or FASTA format:

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F2 coagulation factor II (thrombin) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000506 Homo sapiens coagulation factor II (thrombin) (F2), mRNA. ORF Sequence $542.01
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Antibody Services
Protein Services


Gene Symbol F2
Entrez Gene ID 2147
Full Name coagulation factor II (thrombin)
Synonyms PT
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p11

Summary Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008].
Disorder

MIM: 176930

Hypoprothrombinemia, 613679 (3); Dysprothrombinemia, 613679 (3);

mRNA Protein Product Sequence Price Select
NM_000506, 169808403 NP_000497, 4503635 prothrombin preproprotein Full Length $585.22
ORF Sequence $542.01
KEGG
hsa04610Complement and coagulation cascades
hsa04810Regulation of actin cytoskeleton
hsa04080Neuroactive ligand-receptor interaction
Pathway Interaction Database
syndecan_4_pathwaySyndecan-4-mediated signaling events
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
WikiPathways
WP15Selenium Pathway
WP558Complement and Coagulation Cascades
WP51Regulation of Actin Cytoskeleton
WP272Blood Clotting Cascade
Reactome
REACT_604Hemostasis
REACT_15380Diabetes pathways
REACT_17015Metabolism of proteins
REACT_733Removal of aminoterminal propeptides from gamma-carboxylated proteins
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_326Intrinsic Pathway
REACT_1132Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
REACT_22161Post-translational protein modification
REACT_1906Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_1439Common Pathway
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
REACT_18283G alpha (q) signalling events
REACT_12051Cell surface interactions at the vascular wall
REACT_19184GPCR downstream signaling
REACT_278Platelet Aggregation (Plug Formation)
REACT_798Platelet activation, signaling and aggregation
REACT_111102Signal Transduction
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_21340GPCR ligand binding
REACT_116125Disease
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_15428Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
REACT_1069PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
REACT_1050Gamma-carboxylation of protein precursors
Homo sapiens (human)F2NP_000497.1
Pan troglodytes (chimpanzee)F2XP_001165233.1
Macaca mulatta (Rhesus monkey)F2NP_001098055.1
Canis lupus familiaris (dog)LOC100856539XP_003639742.1
Bos taurus (cattle)F2NP_776302.1
Mus musculus (house mouse)F2NP_034298.1
Rattus norvegicus (Norway rat)F2NP_075213.2
Gallus gallus (chicken)F2NP_989936.1
Danio rerio (zebrafish)f2NP_998555.1
GeneCards F2
PDB 3BIV, 2C8W, 1VZQ, 1C4U, 2ZO3, 1NY2, 2ZFR, 1K21, 1BCU, 1KTT, 1QJ6, 3QGN, 2C93, 2PW8, 2C90, 1DOJ, 1D3T, 1TOM, 1HAO, 1T4U, 2ZHW, 3RML, 2GP9, 1QHR, 1AD8, 1OYT, 1OOK, 2BVS, 1UVS, 4HFP, 1D3P, 2ZNK, 3JZ1, 1TA6, 2UUK, 2JH0, 1H8I, 3HKJ, 1THP, 3SHA, 1AY6, 2C8Z, 1HLT, 3RLY, 1PPB, 3SI4, 3T5F, 1FPC, 1MU6, 4THN, 3QX5, 4HFY, 2BVR, 3BEI, 2PGQ, 2ANM, 3BV9, 1NZQ, 1BA8, 3P6Z, 2H9T, 1SHH, 3HAT, 1ZGV, 1EOJ, 3QTV, 3PO1, 1QJ1, 3EE0, 1D4P, 1EB1, 3P70, 2ZDV, 1UMA, 1SB1, 3UTU, 3K65, 3U69, 1DWD, 1YPK, 1NT1, 4BAH, 1AWF, 1JOU, 1ZGI, 3RMO, 1LHF, 3SQE, 3C27, 3EGK, 2CF8, 1BMM, 7KME, 2ZF0, 1D6W, 1O5G, 1AE8, 1XM1, 1HXF, 1QJ7, 1HBT, 1IHT, 1O2G, 1VR1, 2JH5, 3JZ2, 4DT7, 3NXP, 1WAY, 2R2M, 1BMN, 2B5T, 1GHY, 2A45, 2ZHE, 2BXU, 1C4Y, 1NRO, 4BAO, 1HAI, 3QWC, 4BAK, 2HGT, 1DM4, 2UUJ, 3U8T, 2V3H, 1YPJ, 1A4W, 1A61, 4AX9, 1TMB, 1NRR, 1YPG, 2ZFQ, 2JH6, 4HTC, 3DUX, 2HNT, 3BF6, 1NRN, 2V3O, 3D49, 4E7R, 1C5O, 1A46, 3RM0, 1DWE, 3RMN, 2ZFF, 1NRS, 1GJ4, 1E0F, 3B9F, 3UWJ, 2PKS, 1JMO, 2ZHF, 4DII, 1SGI, 3EQ0, 1LHC, 3LDX, 3SV2, 1Z71, 1T4V, 8KME, 1G30, 1K22, 1HGT, 4E05, 1ABI, 1DE7, 3C1K, 1LHG, 1YPM, 3B23, 3RLW, 1HAH, 1IHS, 1NU9, 2ZIQ, 1D9I, 1TBZ, 1THR, 1MUE, 1THS, 4AYV, 1HAG, 2A0Q, 1B7X, 2OD3, 3U9A, 3SI3, 1GHW, 1MU8, 1TQ7, 1TMT, 1CA8, 1HDT, 2C8Y, 3E6P, 1WBG, 2UUF, 1SFQ, 1SG8, 4BAN, 1GHX, 3S7K, 1BB0, 1AWH, 1EOL, 1QUR, 1G37, 2ANK, 1P8V, 2GDE, 4DIH, 2PGB, 1A5G, 1XMN, 4E06, 1HXE, 1YPE, 2BDY, 4AZ2, 1FPH, 2FES, 1BHX, 3DT0, 1MH0, 1Z8J, 3SHC, 2ZFP, 2BXT, 1A3E, 1C1U, 1C1W, 3RMM, 1RD3, 1DWB, 2THF, 4H6T, 3S7H, 1NO9, 1KTS, 3LU9, 3QLP, 3GIS, 2AFQ, 1C5L, 1GJ5, 1W7G, 3DA9, 2FEQ, 1HAP, 3GIC, 1TMU, 1ZRB, 1C4V, 1DIT, 3HTC, 3P17, 1BTH, 1AI8, 3SQH, 3TU7, 3PMH, 1B5G, 1D3Q, 3U8R, 3BIU, 1A2C, 1AHT, 1NRQ, 1G32, 4AYY, 2C8X, 1TQ0, 2ZGB, 3U98, 2ZC9, 4H6S, 1GHV, 4BAM, 3BEF, 3DHK, 1AIX, 4BAQ, 2ZGX, 1C5N, 1YPL, 1ABJ, 1LHD, 1RIW, 1Z8I, 3R3G, 1NRP, 1NU7, 1O0D, 2CN0, 1QBV, 1C1V, 4DY7, 1TB6, 3QDZ, 3DD2, 3U8O, 5GDS, 3QTO, 1A3B, 2A2X, 3RM2, 1TA2, 3F68, 1SR5, 1LHE, 1AFE, 2ZI2, 1SL3, 2HWL, 1JWT, 1DWC, 1TWX, 2CF9, 1NM6, 2ZDA, 2BVX, 1DX5, 2ZHQ, 1HUT, 1D3D, 2HPP, 2ZG0, 1H8D, 2HPQ
UniProt P00734
MIM 176930
Ensembl ENSG00000180210
HGNC 3535
HPRD 01488

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
prothrombin
Names
prothrombin
serine protease
prothrombin B-chain
prepro-coagulation factor II
NP_000497.1

Interactant

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