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F5 coagulation factor V (proaccelerin, labile factor) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000130 Homo sapiens coagulation factor V (proaccelerin, labile factor) (F5), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol F5
Entrez Gene ID 2153
Full Name coagulation factor V (proaccelerin, labile factor)
Synonyms FVL, PCCF, RPRGL1, THPH2
General protein information
Preferred Names
coagulation factor V
Names
coagulation factor V
factor V Leiden
proaccelerin, labile factor
activated protein c cofactor
coagulation factor V jinjiang A2 domain
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q23

Summary This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008].
Disorder

MIM: 612309

Factor V deficiency, 227400 (3); {Thrombophilia, susceptibility to,

mRNA Protein Product Sequence Price Select
NM_000130, 119395710 NP_000121, 105990535 coagulation factor V precursor ORF Sequence $3500.00
KEGG
hsa04610Complement and coagulation cascades
WikiPathways
WP272Blood Clotting Cascade
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_1439Common Pathway
REACT_1280Response to elevated platelet cytosolic Ca2+
Homo sapiens (human)F5NP_000121.2
Pan troglodytes (chimpanzee)F5XP_513984.4
Macaca mulatta (Rhesus monkey)F5XP_001093072.2
Canis lupus familiaris (dog)F5XP_005622605.1
Bos taurus (cattle)F5NP_776304.1
Mus musculus (house mouse)F5NP_032002.1
Rattus norvegicus (Norway rat)F5NP_001041343.1
Gallus gallus (chicken)F5XP_001231901.3
Danio rerio (zebrafish)f5NP_001007209.2
Xenopus (Silurana) tropicalis (western clawed frog)f5XP_002935820.2
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0006508proteolysisIEA
GO:0007155cell adhesionIEA
GO:0007596blood coagulationTAS
GO:0008015blood circulationIEA
GO:0030168platelet activationTAS
Component
IDNameEvidence
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
GO:0005886plasma membraneTAS
GO:0016020membraneIDA
GO:0031093platelet alpha granule lumenTAS
Function
IDNameEvidence
GO:0004252serine-type endopeptidase activityIEA
GO:0005507copper ion bindingIEA
GO:0005515protein bindingIPI
GeneCards F5
PDB 1Y61, 3P70, 3P6Z, 1CZS, 1CZV, 1FV4, 1CZT, 3S9C
UniProt P12259
MIM 612309
HGNC 3542
HPRD 01964

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the F5 gene?

The F5 gene provides instructions for making a protein called coagulation factor V. Coagulation factors are a group of related proteins that make up the coagulation system, a series of chemical reactions that form blood clots. After an injury, clots seal off blood vessels to stop bleeding and trigger blood vessel repair.

The factor V protein is made primarily by cells in the liver. The protein circulates in the bloodstream in an inactive form until the coagulation system is activated by an injury that damages blood vessels. When coagulation factor V is activated, it interacts with coagulation factor X. The active forms of these two coagulation factors (written as factor Va and factor Xa, respectively) form a complex that converts an important coagulation protein called prothrombin to its active form, thrombin. Thrombin then converts a protein called fibrinogen into fibrin, which is the material that forms the clot.

Coagulation factor V has another role in regulating the coagulation system through its interaction with activated protein C (APC). APC normally inactivates coagulation factor V by cutting (cleaving) it at specific sites. This inactivation slows down the clotting process and prevents clots from growing too large. When coagulation factor V is cleaved at a particular site (protein position 506), it can work with APC to inactivate factor VIIIa, which is another protein that is essential for normal blood clotting.

Interactant

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