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F5 coagulation factor V (proaccelerin, labile factor) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000130 Homo sapiens coagulation factor V (proaccelerin, labile factor) (F5), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol F5
Entrez Gene ID 2153
Full Name coagulation factor V (proaccelerin, labile factor)
Synonyms FVL, PCCF
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q23

Summary This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008].
Disorder

MIM: 612309

Factor V deficiency, 227400 (3); {Thrombophilia, susceptibility to,

mRNA Protein Product Sequence Price Select
NM_000130, 119395710 NP_000121, 105990535 coagulation factor V precursor ORF Sequence $3500.00
KEGG
hsa04610Complement and coagulation cascades
WikiPathways
WP272Blood Clotting Cascade
WP558Complement and Coagulation Cascades
Reactome
REACT_604Hemostasis
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_798Platelet activation, signaling and aggregation
REACT_1439Common Pathway
Homo sapiens (human)F5NP_000121.2
Pan troglodytes (chimpanzee)F5XP_513984.4
Macaca mulatta (Rhesus monkey)F5XP_001093072.2
Canis lupus familiaris (dog)F5XP_003435037.1
Bos taurus (cattle)F5NP_776304.1
Mus musculus (house mouse)F5NP_032002.1
Rattus norvegicus (Norway rat)F5NP_001041343.1
Gallus gallus (chicken)F5XP_001231901.2
Danio rerio (zebrafish)f5NP_001007209.2
GeneCards F5
PDB 1Y61, 3P70, 3P6Z, 1CZS, 1CZV, 1FV4, 1CZT, 3S9C
UniProt P12259
MIM 612309
Ensembl ENSG00000198734
HGNC 3542
HPRD 01964

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
coagulation factor V
Names
coagulation factor V
factor V Leiden
proaccelerin, labile factor
activated protein c cofactor
coagulation factor V jinjiang A2 domain

Interactant



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