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F7 coagulation factor VII (serum prothrombin conversion accelerator) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000131 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001267554 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_019616 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Related Services

Gene Symbol F7
Entrez Gene ID 2155
Full Name coagulation factor VII (serum prothrombin conversion accelerator)
Synonyms
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q34

Summary This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Disorder

MIM: 613878

mRNA Protein Product Sequence Price Select
NM_000131, 388890241 NP_000122, 4503645 coagulation factor VII isoform a preproprotein ORF Sequence $360.00
NM_001267554, 388890244 NP_001254483, 388890245 coagulation factor VII isoform c preproprotein ORF Sequence $400.00
NM_019616, 388890242 NP_062562, 10518503 coagulation factor VII isoform b preproprotein ORF Sequence $360.00
KEGG
hsa04610Complement and coagulation cascades
WikiPathways
WP15Selenium Pathway
WP272Blood Clotting Cascade
WP558Complement and Coagulation Cascades
Reactome
REACT_604Hemostasis
REACT_24941Circadian Clock
REACT_22161Post-translational protein modification
REACT_111118BMAL1:CLOCK/NPAS2 Activates Circadian Expression
REACT_1573Extrinsic Pathway
REACT_733Removal of aminoterminal propeptides from gamma-carboxylated proteins
REACT_1069PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
REACT_1050Gamma-carboxylation of protein precursors
REACT_17015Metabolism of proteins
REACT_1132Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
REACT_1906Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
Homo sapiens (human)F7NP_062562.1
Pan troglodytes (chimpanzee)F7XP_001149885.2
Macaca mulatta (Rhesus monkey)F7NP_001073605.1
Canis lupus familiaris (dog)F7NP_001041498.1
Bos taurus (cattle)F7NP_001029978.1
Mus musculus (house mouse)F7NP_034302.2
Rattus norvegicus (Norway rat)F7NP_690059.1
Gallus gallus (chicken)F7NP_989773.1
Danio rerio (zebrafish)zgc:163025NP_001083027.1

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
coagulation factor VII
Names
coagulation factor VII
eptacog alfa
proconvertin
FVII coagulation protein
NP_000122.1
NP_001254483.1
NP_062562.1

Interactant



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