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F7 coagulation factor VII (serum prothrombin conversion accelerator) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000131 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001267554 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_019616 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
XM_006719963 PREDICTED: Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Related Services

Gene Symbol F7
Entrez Gene ID 2155
Full Name coagulation factor VII (serum prothrombin conversion accelerator)
Synonyms SPCA
General protein information
Preferred Names
coagulation factor VII
Names
coagulation factor VII
eptacog alfa
proconvertin
FVII coagulation protein
NP_000122.1
NP_001254483.1
NP_062562.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q34

Summary This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Disorder

MIM: 613878

mRNA Protein Product Sequence Price Select
NM_000131, 388890241 NP_000122, 4503645 coagulation factor VII isoform a preproprotein ORF Sequence $360.00
NM_001267554, 388890244 NP_001254483, 388890245 coagulation factor VII isoform c preproprotein ORF Sequence $400.00
NM_019616, 388890242 NP_062562, 10518503 coagulation factor VII isoform b preproprotein ORF Sequence $360.00
XM_006719963, 578825304 XP_006720026, 578825305 coagulation factor VII isoform X1 ORF Sequence $400.00
KEGG
hsa04610Complement and coagulation cascades
WikiPathways
WP15Selenium Pathway
WP272Blood Clotting Cascade
Reactome
REACT_604Hemostasis
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_1573Extrinsic Pathway
REACT_1906Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
REACT_733Removal of aminoterminal propeptides from gamma-carboxylated proteins
REACT_1050Gamma-carboxylation of protein precursors
REACT_17015Metabolism of proteins
REACT_1069PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
REACT_1132Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
REACT_22161Post-translational protein modification
REACT_24941Circadian Clock
REACT_111118BMAL1:CLOCK,NPAS2 activates circadian gene expression
Homo sapiens (human)F7NP_062562.1
Pan troglodytes (chimpanzee)F7XP_001149885.2
Macaca mulatta (Rhesus monkey)F7NP_001073605.1
Canis lupus familiaris (dog)F7NP_001041498.1
Bos taurus (cattle)F7NP_001029978.1
Mus musculus (house mouse)F7NP_034302.2
Rattus norvegicus (Norway rat)F7NP_690059.1
Gallus gallus (chicken)F7NP_989773.1
Danio rerio (zebrafish)zgc:163025NP_001083027.1
Xenopus (Silurana) tropicalis (western clawed frog)f7NP_001072819.1
Process
IDNameEvidence
GO:0002690positive regulation of leukocyte chemotaxisIDA
GO:0006508proteolysisTAS
GO:0007596blood coagulationTAS
GO:0007598blood coagulation, extrinsic pathwayTAS
GO:0007623circadian rhythmIEA
GO:0010641positive regulation of platelet-derived growth factor receptor signaling pathwayIDA
GO:0017187peptidyl-glutamic acid carboxylationTAS
GO:0030194positive regulation of blood coagulationIEA
GO:0030335positive regulation of cell migrationTAS
GO:0031100organ regenerationIEA
GO:0032571response to vitamin KIEA
GO:0043627response to estrogenIEA
GO:0043687post-translational protein modificationTAS
GO:0044267cellular protein metabolic processTAS
GO:0050927positive regulation of positive chemotaxisIDA
GO:0051897positive regulation of protein kinase B signalingIDA
GO:0060416response to growth hormoneIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
GO:0005788endoplasmic reticulum lumenTAS
GO:0005796Golgi lumenTAS
GO:0005886plasma membraneTAS
GO:0031982vesicleIEA
Function
IDNameEvidence
GO:0001948glycoprotein bindingIPI
GO:0004252serine-type endopeptidase activityIEA
GO:0005102receptor bindingIEA
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GO:0008236serine-type peptidase activityTAS
GeneCards F7
UniProt B4DPM2, P08709
Vega OTTHUMG00000017373
MIM 613878
Ensembl ENSG00000057593
HGNC 3544
HPRD 01965

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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