F7 coagulation factor VII (serum prothrombin conversion accelerator) [Homo sapiens (human)]
| Gene Symbol | F7 |
| Entrez Gene ID | 2155 |
| Full Name | coagulation factor VII (serum prothrombin conversion accelerator) |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
13 13q34 |
| Summary | This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. [provided by RefSeq]. |
| Disorder | MIM: 613878 |
| mRNA | NM_000131, 116805320 |
| Protein | NP_000122, 4503645 |
| Product | coagulation factor VII isoform a precursor |
| RefSeq Status | REVIEWED |
| mRNA | NM_019616, 116805323 |
| Protein | NP_062562, 10518503 |
| Product | coagulation factor VII isoform b precursor |
| RefSeq Status | REVIEWED |
| hsa04610 | Complement and coagulation cascades |
WikiPathways
| WP272 | Blood Clotting Cascade |
| WP558 | Complement and Coagulation Cascades |
| WP15 | Selenium Pathway |
Reactome
| REACT_1573 | Extrinsic Pathway |
| REACT_1069 | Post-translational modification: gamma carboxylation and hypusine formation |
| REACT_22161 | Post-translational protein modification |
| REACT_1050 | Gamma-carboxylation of protein precursors |
| REACT_733 | Removal of aminoterminal propeptides from gamma-carboxylated proteins |
| REACT_17015 | Metabolism of proteins |
| REACT_1132 | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| REACT_1906 | Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus |
| REACT_2051 | Formation of Fibrin Clot (Clotting Cascade) |
| REACT_604 | Hemostasis |
| REACT_24941 | Circadian Clock |
| Homo sapiens (human) | F7 | NP_062562.1 |
| Pan troglodytes (chimpanzee) | F7 | XP_001149885.1 |
| Canis lupus familiaris (dog) | F7 | XP_849513.1 |
| Bos taurus (cattle) | F7 | NP_001029978.1 |
| Bos taurus (cattle) | LOC785517 | XP_001250512.1 |
| Mus musculus (house mouse) | F7 | NP_034302.1 |
| Rattus norvegicus (Norway rat) | F7 | NP_690059.1 |
| Gallus gallus (chicken) | F7 | NP_989773.1 |
| Danio rerio (zebrafish) | zgc:163025 | NP_001083027.1 |
| ID | Name | Evidence |
| GO:0002690 | positive regulation of leukocyte chemotaxis | IDA |
| GO:0006508 | proteolysis | TAS |
| GO:0006916 | anti-apoptosis | TAS |
| GO:0007596 | blood coagulation | TAS |
| GO:0007598 | blood coagulation, extrinsic pathway | EXP |
| GO:0007623 | circadian rhythm | IEA |
| GO:0009725 | response to hormone stimulus | IEA |
| GO:0010641 | positive regulation of platelet-derived growth factor receptor signaling pathway | IDA |
| GO:0014070 | response to organic cyclic compound | IEA |
| GO:0017187 | peptidyl-glutamic acid carboxylation | TAS |
| GO:0030194 | positive regulation of blood coagulation | IEA |
| GO:0030335 | positive regulation of cell migration | TAS |
| GO:0031100 | organ regeneration | IEA |
| GO:0031667 | response to nutrient levels | IEA |
| GO:0032571 | response to vitamin K | IEA |
| GO:0043627 | response to estrogen stimulus | IEA |
| GO:0043687 | post-translational protein modification | TAS |
| GO:0044267 | cellular protein metabolic process | TAS |
| GO:0050927 | positive regulation of positive chemotaxis | IDA |
| GO:0051897 | positive regulation of protein kinase B signaling cascade | IDA |
| GO:0060416 | response to growth hormone stimulus | IEA |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | EXP |
| GO:0005615 | extracellular space | IEA |
| GO:0005788 | endoplasmic reticulum lumen | TAS |
| GO:0005796 | Golgi lumen | TAS |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
| GO:0042598 | vesicular fraction | IEA |
Function
| ID | Name | Evidence |
| GO:0001948 | glycoprotein binding | IPI |
| GO:0004252 | serine-type endopeptidase activity | IEA |
| GO:0005102 | receptor binding | IEA |
| GO:0005509 | calcium ion binding | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008233 | peptidase activity | IEA |
| GO:0008236 | serine-type peptidase activity | TAS |
| GeneCards | F7 |
| PDB | 2BZ6, 2A2Q, 1O5D, 1CVW, 1QFK, 1FAK, 1W8B, 2ZZU, 2FLR, 1YGC, 1JBU, 1W0Y, 2EC9, 1WSS, 2C4F, 2ZWL, 2F9B, 1W7X, 2B7D, 1KLI, 2ZP0, 1DAN, 1WV7, 2FLB, 1F7M, 2AEI, 2PUQ, 1F7E, 1W2K, 1FF7, 1WTG, 1WUN, 2FIR, 1Z6J, 2B8O, 1NL8, 1FFM, 1DVA, 2AER, 1WQV, 3ELA, 1J9C, 1KLJ, 1BF9 |
| UniProt | P08709 |
| MIM | 613878 |
| Ensembl | ENSG00000057593 |
| HGNC | 3544 |
| HPRD | 01965 |
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