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F13A1 coagulation factor XIII, A1 polypeptide [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25882 NM_000129 Homo sapiens coagulation factor XIII, A1 polypeptide (F13A1), mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25882 XM_006715010 PREDICTED: Homo sapiens coagulation factor XIII, A1 polypeptide (F13A1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25882C NM_000129 Homo sapiens coagulation factor XIII, A1 polypeptide (F13A1), mRNA. Customized vector On-demand 12-14 $329.00
OHu25882C XM_006715010 PREDICTED: Homo sapiens coagulation factor XIII, A1 polypeptide (F13A1), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol F13A1
Entrez Gene ID 2162
Full Name coagulation factor XIII, A1 polypeptide
Synonyms F13A
General protein information
Preferred Names
coagulation factor XIII A chain
Names
coagulation factor XIII A chain
TGase
factor XIIIa
fibrinoligase
FSF, A subunit
coagulation factor XIIIa
transglutaminase A chain
transglutaminase. plasma
fibrin stabilizing factor, A subunit
coagulation factor XIII, A polypeptide
protein-glutamine gamma-glutamyltransferase A chain
bA525O21.1 (coagulation factor XIII, A1 polypeptide)
NP_000120.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p25.3-p24.3

Summary This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008].
Disorder

MIM: 134570

Factor XIIIA deficiency, 613225 (3)

mRNA Protein Product Sequence Price Select
NM_000129, 119395708 NP_000120, 119395709 coagulation factor XIII A chain precursor ORF Sequence $700.00
XM_006715010, 578811466 XP_006715073, 578811467 coagulation factor XIII A chain isoform X1 ORF Sequence $700.00
KEGG
hsa04610Complement and coagulation cascades
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_1439Common Pathway
REACT_1280Response to elevated platelet cytosolic Ca2+
Homo sapiens (human)F13A1NP_000120.2
Macaca mulatta (Rhesus monkey)F13A1XP_001096779.2
Canis lupus familiaris (dog)F13A1XP_535876.2
Bos taurus (cattle)F13A1NP_001161366.1
Mus musculus (house mouse)F13a1NP_083060.2
Rattus norvegicus (Norway rat)F13a1NP_067730.2
Gallus gallus (chicken)F13A1NP_990016.1
Danio rerio (zebrafish)f13a1bNP_001070622.1
Xenopus (Silurana) tropicalis (western clawed frog)f13a1XP_002936471.1
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0007596blood coagulationTAS
GO:0018149peptide cross-linkingIEA
GO:0030168platelet activationTAS
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0031093platelet alpha granule lumenTAS
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0003810protein-glutamine gamma-glutamyltransferase activityTAS
GO:0046872metal ion bindingIEA
GeneCards F13A1
PDB 1GGT, 1EVU, 1F13, 1EX0, 1QRK, 1GGY, 1FIE, 4KTY, 1GGU
UniProt P00488
Vega OTTHUMG00000014186
MIM 134570
Ensembl ENSG00000124491
HGNC 3531
HPRD 00604

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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