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ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu23457D NM_000690 Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu23602D NM_001204889 Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK On-demand 7-9 Starting from $99
OHu23457C NM_000690 Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 1, mRNA. Customized vector In-stock 5-7 Starting from $99
OHu23602C NM_001204889 Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 2, mRNA. Customized vector On-demand 7-9 Starting from $99

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Gene Symbol ALDH2
Entrez Gene ID 217
Full Name aldehyde dehydrogenase 2 family (mitochondrial)
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011].

MIM: 100650

Alcohol sensitivity, acute, 610251 (3); {Hangover, susceptibility

mRNA Protein Product Sequence Price Select
NM_000690, 325910902 NP_000681, 25777732 aldehyde dehydrogenase, mitochondrial isoform 1 precursor ORF Sequence $550.00
NM_001204889, 325910903 NP_001191818, 325910904 aldehyde dehydrogenase, mitochondrial isoform 2 precursor ORF Sequence $550.00
hsa00310Lysine degradation
hsa00040Pentose and glucuronate interconversions
hsa00010Glycolysis / Gluconeogenesis
hsa00340Histidine metabolism
hsa00330Arginine and proline metabolism
hsa00640Propanoate metabolism
hsa00053Ascorbate and aldarate metabolism
hsa00071Fatty acid degradation
hsa00561Glycerolipid metabolism
hsa00380Tryptophan metabolism
hsa00620Pyruvate metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00410beta-Alanine metabolism
hsa_M00135GABA biosynthesis, eukaryotes, putrescine => GABA
WP465Tryptophan metabolism
WP206Fatty Acid Omega Oxidation
META_PWY66-21ethanol degradation II
META_PWY-0putrescine degradation III
META_PWY66-161ethanol degradation III (oxidative)
META_PWY66-162ethanol degradation IV
META_PWY-6313serotonin degradation
HUMAN_PWY66-162ethanol degradation IV
HUMAN_PWY66-161oxidative ethanol degradation III
HUMAN_PWY66-21ethanol degradation II
HUMAN_PWY-6342noradrenaline and adrenaline degradation
HUMAN_PWY-6318phenylalanine degradation IV (mammalian, via side chain)
HUMAN_PWY-0putrescine degradation III
HUMAN_PWY-6313serotonin degradation
HUMAN_2PHENDEG-PWYphenylethylamine degradation I
REACT_13433Biological oxidations
REACT_34Ethanol oxidation
REACT_13705Phase 1 - Functionalization of compounds
REACT_13583Neurotransmitter Clearance In The Synaptic Cleft
REACT_13477Transmission across Chemical Synapses
REACT_15391Serotonin clearance from the synaptic cleft
REACT_13685Neuronal System
REACT_15532Metabolism of serotonin
Homo sapiens (human)ALDH2NP_000681.2
Pan troglodytes (chimpanzee)ALDH2XP_509379.3
Macaca mulatta (Rhesus monkey)ALDH2XP_002808038.1
Canis lupus familiaris (dog)ALDH2XP_853628.1
Bos taurus (cattle)ALDH2NP_001068835.1
Mus musculus (house mouse)Aldh2NP_033786.1
Rattus norvegicus (Norway rat)Aldh2NP_115792.1
Gallus gallus (chicken)ALDH2XP_415171.3
Danio rerio (zebrafish)aldh2.1NP_956784.1
Danio rerio (zebrafish)aldh2lXP_002662252.1
Danio rerio (zebrafish)aldh2.2NP_998466.2
Drosophila melanogaster (fruit fly)AldhNP_609285.1
Caenorhabditis elegansalh-1NP_498081.2
Caenorhabditis elegansalh-2NP_503467.2
Arabidopsis thaliana (thale cress)ALDH2B4NP_190383.1
Xenopus (Silurana) tropicalis (western clawed frog)aldh2NP_001004907.1
GO:0005975carbohydrate metabolic processTAS
GO:0006066alcohol metabolic processTAS
GO:0006068ethanol catabolic processIEA
GO:0006069ethanol oxidationTAS
GO:0006805xenobiotic metabolic processTAS
GO:0007268synaptic transmissionTAS
GO:0042136neurotransmitter biosynthetic processTAS
GO:0044281small molecule metabolic processTAS
GO:0005759mitochondrial matrixTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0004029aldehyde dehydrogenase (NAD) activityEXP
GO:0004030aldehyde dehydrogenase [NAD(P)+] activityTAS
GO:0009055electron carrier activityTAS
GeneCards ALDH2
UniProt P05091
Vega OTTHUMG00000169603
MIM 100650
Ensembl ENSG00000111275
HGNC 404
HPRD 00003

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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