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ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000690 Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001204889 Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol ALDH2
Entrez Gene ID 217
Full Name aldehyde dehydrogenase 2 family (mitochondrial)
Synonyms ALDH-E2, ALDHI, ALDM, MGC1806
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011].

MIM: 100650

Alcohol sensitivity, acute, 610251 (3); {Hangover, susceptibility

mRNA Protein Product Sequence Price Select
NM_000690, 325910902 NP_000681, 25777732 aldehyde dehydrogenase, mitochondrial isoform 1 precursor ORF Sequence $550.00
NM_001204889, 325910903 NP_001191818, 325910904 aldehyde dehydrogenase, mitochondrial isoform 2 precursor ORF Sequence $550.00
hsa00010Glycolysis / Gluconeogenesis
hsa00053Ascorbate and aldarate metabolism
hsa00310Lysine degradation
hsa00071Fatty acid metabolism
hsa00410beta-Alanine metabolism
hsa00340Histidine metabolism
hsa_M00135GABA biosynthesis, eukaryotes, putrescine => GABA
hsa00620Pyruvate metabolism
hsa00330Arginine and proline metabolism
hsa00380Tryptophan metabolism
hsa00640Propanoate metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00040Pentose and glucuronate interconversions
hsa00561Glycerolipid metabolism
WP465Tryptophan metabolism
WP206Fatty Acid Omega Oxidation
META_PWY-0putrescine degradation III
HUMAN_PWY-6318phenylalanine degradation IV (mammalian, via side chain)
META_PWY66-21ethanol degradation II
HUMAN_PWY66-162ethanol degradation IV
HUMAN_PWY-6313serotonin degradation
HUMAN_2PHENDEG-PWYphenylethylamine degradation I
HUMAN_PWY-0putrescine degradation III
META_PWY66-161oxidative ethanol degradation III
HUMAN_PWY66-21ethanol degradation II
HUMAN_PWY-6342noradrenaline and adrenaline degradation
HUMAN_PWY66-161oxidative ethanol degradation III
META_PWY66-162ethanol degradation IV
META_PWY-6342noradrenaline and adrenaline degradation
REACT_15532Metabolism of serotonin
REACT_15391Serotonin clearance from the synaptic cleft
REACT_13583Neurotransmitter Clearance In The Synaptic Cleft
REACT_13477Transmission across Chemical Synapses
REACT_13705Phase 1 - Functionalization of compounds
REACT_13685Neuronal System
REACT_34Ethanol oxidation
REACT_13433Biological oxidations
Homo sapiens (human)ALDH2NP_000681.2
Pan troglodytes (chimpanzee)ALDH2XP_509379.3
Macaca mulatta (Rhesus monkey)ALDH2XP_002808038.1
Canis lupus familiaris (dog)ALDH2XP_853628.1
Bos taurus (cattle)ALDH2NP_001068835.1
Mus musculus (house mouse)Aldh2NP_033786.1
Rattus norvegicus (Norway rat)Aldh2NP_115792.1
Gallus gallus (chicken)ALDH2XP_415171.3
Danio rerio (zebrafish)aldh2.2NP_998466.2
Danio rerio (zebrafish)aldh2.1NP_956784.1
Danio rerio (zebrafish)aldh2lXP_002662252.1
Drosophila melanogaster (fruit fly)AldhNP_609285.1
Caenorhabditis elegansalh-1NP_498081.2
Caenorhabditis elegansalh-2NP_503467.1
Arabidopsis thaliana (thale cress)ALDH2B4NP_190383.1
GeneCards ALDH2
PDB 2VLE, 4FR8, 1NZZ, 3INJ, 1O01, 1O00, 1NZX, 3SZ9, 3N80, 3N82, 1CW3, 2ONP, 1O05, 1O02, 3N83, 2ONM, 3N81, 1O04, 2ONN, 3INL, 1ZUM, 2ONO, 1NZW, 4FQF
UniProt E7EUE5, B4DW54, P05091
MIM 100650
Ensembl ENSG00000111275
HGNC 404
HPRD 00003

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information


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