FANCG Fanconi anemia, complementation group G [Homo sapiens (human)]
| Gene Symbol | FANCG |
| Entrez Gene ID | 2189 |
| Full Name | Fanconi anemia, complementation group G |
| Synonyms | FAG, XRCC9 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
9 9p13 |
| Summary | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq]. |
| Disorder | MIM: 602956 Fanconi anemia, complementation group G (3) |
| mRNA | NM_004629, 4759335 |
| Protein | NP_004620, 4759336 |
| Product | Fanconi anemia group G protein |
| RefSeq Status | REVIEWED |
| bard1pathway | BARD1 signaling events |
Reactome
| REACT_216 | DNA Repair |
| REACT_18410 | Fanconi Anemia pathway |
| Homo sapiens (human) | FANCG | NP_004620.1 |
| Pan troglodytes (chimpanzee) | FANCG | XP_001165190.1 |
| Canis lupus familiaris (dog) | FANCG | XP_854703.1 |
| Bos taurus (cattle) | FANCG | NP_001095757.1 |
| Mus musculus (house mouse) | Fancg | NP_444311.1 |
| Rattus norvegicus (Norway rat) | Fancg | XP_001076851.1 |
| Gallus gallus (chicken) | FANCG | NP_989709.1 |
| Danio rerio (zebrafish) | fancg | NP_991202.1 |
| Danio rerio (zebrafish) | LOC100333725 | XP_002662099.1 |
| ID | Name | Evidence |
| GO:0000075 | cell cycle checkpoint | TAS |
| GO:0001541 | ovarian follicle development | IEA |
| GO:0006281 | DNA repair | TAS |
| GO:0007005 | mitochondrion organization | IMP |
| GO:0007286 | spermatid development | IEA |
| GO:0009314 | response to radiation | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005737 | cytoplasm | IEA |
| GO:0005739 | mitochondrion | IDA |
Function
| ID | Name | Evidence |
| GO:0003684 | damaged DNA binding | TAS |
| GO:0005515 | protein binding | IPI |
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