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FANCG Fanconi anemia, complementation group G [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004629 Homo sapiens Fanconi anemia, complementation group G (FANCG), mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

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Gene Symbol FANCG
Entrez Gene ID 2189
Full Name Fanconi anemia, complementation group G
Synonyms FAG, XRCC9
General protein information
Preferred Names
Fanconi anemia group G protein
Fanconi anemia group G protein
DNA repair protein XRCC9
X-ray repair, complementing defective, in Chinese hamster, 9
X-ray repair complementing defective repair in Chinese hamster cells 9
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008].

MIM: 602956

Fanconi anemia, complementation group G (3)

mRNA Protein Product Sequence Price Select
NM_004629, 4759335 NP_004620, 4759336 Fanconi anemia group G protein ORF Sequence $700.00
hsa03460Fanconi anemia pathway
hsa_M00413FA core complex
WP2446RB in Cancer
Pathway Interaction Database
bard1pathwayBARD1 signaling events
REACT_216DNA Repair
REACT_18410Fanconi Anemia pathway
REACT_120956Cellular responses to stress
REACT_200744HSF1 activation
REACT_200819Cellular response to heat stress
Homo sapiens (human)FANCGNP_004620.1
Pan troglodytes (chimpanzee)FANCGXP_001165190.1
Macaca mulatta (Rhesus monkey)FANCGXP_001092322.1
Canis lupus familiaris (dog)FANCGXP_854703.1
Bos taurus (cattle)FANCGNP_001095757.1
Mus musculus (house mouse)FancgNP_444311.1
Rattus norvegicus (Norway rat)FancgXP_006238187.1
Gallus gallus (chicken)FANCGNP_989709.1
Danio rerio (zebrafish)fancgNP_991202.1
Xenopus (Silurana) tropicalis (western clawed frog)fancgNP_001120193.1
GO:0000075cell cycle checkpointTAS
GO:0001541ovarian follicle developmentIEA
GO:0006281DNA repairTAS
GO:0007005mitochondrion organizationIMP
GO:0007286spermatid developmentIEA
GO:0009314response to radiationIEA
GO:0005886plasma membraneIDA
GO:0043240Fanconi anaemia nuclear complexIDA
GO:0003684damaged DNA bindingTAS
GO:0005515protein bindingIPI
GeneCards FANCG
UniProt Q53XM5, O15287
Vega OTTHUMG00000019850
MIM 602956
Ensembl ENSG00000221829
HGNC 3588
HPRD 04262

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FANCG gene?

The FANCG gene provides instructions for making a protein that is involved in a cell process known as the Fanconi anemia (FA) pathway. The FA pathway is turned on (activated) when the process of making new copies of DNA, called DNA replication, is blocked due to DNA damage. The FA pathway is particularly responsive to a certain type of DNA damage known as interstrand cross-links (ICLs). ICLs occur when two DNA building blocks (nucleotides) on opposite strands of DNA are abnormally attached or linked together, which stops the process of DNA replication. ICLs can be caused by a buildup of toxic substances produced in the body or by treatment with certain cancer therapy drugs.

The FANCG protein is one of a group of proteins known as the FA core complex. The FA core complex is composed of eight FA proteins (including FANCG) and two proteins called Fanconi anemia-associated proteins (FAAPs). This complex activates two proteins, called FANCD2 and FANCI, by attaching a single molecule called ubiquitin to each of them (a process called monoubiquitination). The activation of these two proteins, which attach (bind) together to form the ID protein complex, attracts DNA repair proteins to the area of DNA damage so the error can be corrected and DNA replication can continue.


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