Sequence in raw or FASTA format:
KIF6 kinesin family member 6 [Homo sapiens (human)]
|Entrez Gene ID
||kinesin family member 6
||C6orf102, dJ1043E3.1, dJ137F1.4, dJ188D3.1
|General protein information
- Preferred Names
- kinesin-like protein KIF6
- kinesin-like protein KIF6
||Homo sapiens (human)
Related articles in PubMed
- Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661.
- Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect. Peng P, et al. PLoS One, 2012. PMID 23236363.
- Association of KIF6 variant with lipid level and angiographic coronary artery disease events risk in the Han Chinese population. Wu G, et al. Molecules, 2012 Sep 21. PMID 23001387.
- KLF6 loss of function in human prostate cancer progression is implicated in resistance to androgen deprivation. Liu X, et al. Am J Pathol, 2012 Sep. PMID 22819534.
- Genome-wide association study of antibody response to smallpox vaccine. Ovsyannikova IG, et al. Vaccine, 2012 Jun 13. PMID 22542470.
See all (38) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Our case-control study suggests that Trp719Arg of KIF6 gene is associated with coronary heart disease in female Han Chinese through a post hoc analysis.
Title: Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect.
KIF6 719Arg allele was not an independent risk factor for angiographic coronary artery disease(CAD)susceptibility in northern China Han populations; it was associated with a significantly higher TG level, which may indicate increased myocardial infarction risk in angiographic CAD patients
Title: Association of KIF6 variant with lipid level and angiographic coronary artery disease events risk in the Han Chinese population.
These data suggest that decreased availability of functional KLF6 contributes to clinical prostate cancer progression.
Title: KLF6 loss of function in human prostate cancer progression is implicated in resistance to androgen deprivation.
In a meta-analysis involving 144,931 participants, the KIF6 719Arg allele was not associated with the relative risk of cardiovascular disease
Title: A common KIF6 polymorphism increases vulnerability to low-density lipoprotein cholesterol: two meta-analyses and a meta-regression analysis.
Assessment of KIF6 genotype is not useful in predicting low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
Title: KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
Carriers of the KIF6 719Arg allele were not at increased risk of CAD/non-fatal MI in a case-control study of Indians (Indo-Europeans) living in Western India.
Title: Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians.
In patients with type 2 diabetes mellitus on hemodialysis, KIF6 Trp719Arg genotypes were not associated with adverse cardiovascular outcomes during follow-up or with the efficacy of atorvastatin therapy.
Title: Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and cardiovascular risk and efficacy of atorvastatin among subjects with diabetes on dialysis: the 4D study.
Discovered influence of polymorphic marker Trp719Arg of KIF6 gene on individual response to therapy with 10 mg/day of atorvastatin.
Title: [Association of a polymorphic marker Trp719Arg of KIF6 gene with effects of atorvastatin and simvastatin in patients with early ischemic heart disease].
A combination of KIF6 719Arg carrier status and C-reactive protein levels modestly improves the prediction of risk of myocardial infarction among white men.
Title: The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study.
Use of KIF6 genotyping to guide statin therapy is not warranted in this heart protection trial, since no impact is found on KIF6 genotype, vascular risk or statin response.
Title: No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study.
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