SLC29A4 solute carrier family 29 (nucleoside transporters), member 4 [Homo sapiens (human)]
| Gene Symbol | SLC29A4 |
| Entrez Gene ID | 222962 |
| Full Name | solute carrier family 29 (nucleoside transporters), member 4 |
| Synonyms | ENT4, FLJ34923, PMAT |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
7 7p22.1 |
| Summary | This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq]. |
| Disorder | MIM: 609149 |
| mRNA | NM_153247, 100913031 |
| Protein | NP_694979, 100913032 |
| Product | equilibrative nucleoside transporter 4 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001040661, 100913033 |
| Protein | NP_001035751, 100913034 |
| Product | equilibrative nucleoside transporter 4 |
| RefSeq Status | REVIEWED |
| REACT_1206 | Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
| REACT_15518 | Transmembrane transport of small molecules |
| REACT_1698 | Metabolism of nucleotides |
| REACT_19118 | SLC-mediated transmembrane transport |
| REACT_22285 | Transport of vitamins, nucleosides, and related molecules |
| Homo sapiens (human) | SLC29A4 | NP_001035751.1 |
| Canis lupus familiaris (dog) | SLC29A4 | XP_547001.2 |
| Bos taurus (cattle) | SLC29A4 | XP_876046.3 |
| Mus musculus (house mouse) | Slc29a4 | NP_666369.1 |
| Rattus norvegicus (Norway rat) | Slc29a4 | XP_221940.1 |
| Danio rerio (zebrafish) | slc29a4 | NP_001074041.1 |
| Drosophila melanogaster (fruit fly) | Ent3 | NP_648608.2 |
| Arabidopsis thaliana (thale cress) | ENT1,AT | NP_564987.2 |
| Arabidopsis thaliana (thale cress) | AT1G02630 | NP_171763.1 |
| ID | Name | Evidence |
| GO:0015858 | nucleoside transport | TAS |
| GO:0055085 | transmembrane transport | TAS |
| GO:0055086 | nucleobase, nucleoside and nucleotide metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | TAS |
| GO:0016021 | integral to membrane | IEA |
| GO:0016324 | apical plasma membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0005337 | nucleoside transmembrane transporter activity | TAS |
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