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FGA fibrinogen alpha chain [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_000508 Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha-E, mRNA. Full Length $1279.25
ORF Sequence $754.29
NM_021871 Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha, mRNA. Full Length $640.90
ORF Sequence $561.15


Gene Symbol FGA
Entrez Gene ID 2243
Full Name fibrinogen alpha chain
Synonyms Fib2, MGC119422, MGC119423, MGC119425
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q28
Summary The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq].
Disorder

MIM: 134820

Dysfibrinogenemia, alpha type, causing bleeding diathesis (3);
mRNA NM_000508, 70906432
Protein NP_000499, 4503689
Product fibrinogen alpha chain isoform alpha-E preproprotein
RefSeq Status REVIEWED
mRNA NM_021871, 70906433
Protein NP_068657, 11761629
Product fibrinogen alpha chain isoform alpha preproprotein
RefSeq Status REVIEWED
KEGG
hsa04610Complement and coagulation cascades
WikiPathways
WP272Blood Clotting Cascade
Reactome
REACT_20Formation of Platelet plug
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Intergrins
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_318Platelet degranulation
REACT_604Hemostasis
REACT_15523Integrin alphaIIb beta3 signaling
REACT_13552Integrin cell surface interactions
REACT_1439Common Pathway
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_798Platelet Activation
REACT_278Platelet Aggregation (Plug Formation)
Homo sapiens (human)FGANP_000499.1
Pan troglodytes (chimpanzee)FGAXP_001136067.1
Canis lupus familiaris (dog)FGAXP_532697.2
Mus musculus (house mouse)FgaNP_034326.1
Rattus norvegicus (Norway rat)FgaNP_001008724.1
Gallus gallus (chicken)FGAXP_001232367.1
Danio rerio (zebrafish)wu:fb59b03XP_002660415.1
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0007165signal transductionIEA
GO:0007596blood coagulationTAS
GO:0030168platelet activationTAS
GO:0051258protein polymerizationIEA
GO:0051592response to calcium ionIDA
Component
IDNameEvidence
GO:0005576extracellular regionEXP
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005577fibrinogen complexIEA
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneEXP
GO:0009897external side of plasma membraneIDA
GO:0031091platelet alpha granuleIDA
GO:0031093platelet alpha granule lumenTAS
Function
IDNameEvidence
GO:0005102receptor bindingIEA
GO:0005515protein bindingIPI
GO:0030674protein binding, bridgingIEA
GO:0043499eukaryotic cell surface bindingIDA
GeneCards FGA
PDB 1RF1, 1LT9, 1FZC, 1N8E, 2HLO, 1RE4, 1RE3, 1FZA, 1LTJ, 1FZG, 2FFD, 2OYH, 1FZE, 1RF0, 3BVH, 2OYI, 3HUS, 3H32, 1YCP, 1BBR, 1FZB, 2Q9I, 2HPC, 3GHG, 1N86, 1FZD, 2A45, 1FZF, 2H43, 3E1I, 2Z4E, 2HOD
UniProt P02671
MIM 134820
Ensembl ENSG00000171560
HGNC 3661
HPRD 00619

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