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FGA fibrinogen alpha chain [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000508 Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha-E, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_021871 Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

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Gene Symbol FGA
Entrez Gene ID 2243
Full Name fibrinogen alpha chain
Synonyms Fib2, MGC119422, MGC119423, MGC119425
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q28

Summary The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008].
Disorder

MIM: 134820

Dysfibrinogenemia, alpha type, causing bleeding diathesis (3);

mRNA Protein Product Sequence Price Select
NM_000508, 70906432 NP_000499, 4503689 fibrinogen alpha chain isoform alpha-E preproprotein ORF Sequence $750.00
NM_021871, 70906433 NP_068657, 11761629 fibrinogen alpha chain isoform alpha preproprotein ORF Sequence $700.00
KEGG
hsa04610Complement and coagulation cascades
WikiPathways
WP272Blood Clotting Cascade
Reactome
REACT_278Platelet Aggregation (Plug Formation)
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Intergrins
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_111102Signal Transduction
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_116125Disease
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_318Platelet degranulation
REACT_15523Integrin alphaIIb beta3 signaling
REACT_75925Amyloids
REACT_1439Common Pathway
REACT_13552Integrin cell surface interactions
Homo sapiens (human)FGANP_000499.1
Pan troglodytes (chimpanzee)FGAXP_001136067.1
Macaca mulatta (Rhesus monkey)FGAXP_001088855.2
Canis lupus familiaris (dog)FGAXP_532697.2
Mus musculus (house mouse)FgaNP_001104518.1
Rattus norvegicus (Norway rat)FgaNP_001008724.1
Gallus gallus (chicken)FGAXP_001232367.1
Danio rerio (zebrafish)fgaNP_001181918.1

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
fibrinogen alpha chain
Names
fibrinogen alpha chain
fibrinogen, A alpha polypeptide

Interactant



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