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FGA fibrinogen alpha chain [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19142 NM_021871 Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu19692 NM_000508 Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha-E, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu19142C NM_021871 Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha, mRNA. Customized vector On-demand TBD $269.00
OHu19692C NM_000508 Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha-E, mRNA. Customized vector On-demand TBD $329.00

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Gene Symbol FGA
Entrez Gene ID 2243
Full Name fibrinogen alpha chain
Synonyms Fib2
General protein information
Preferred Names
fibrinogen alpha chain
Names
fibrinogen alpha chain
fibrinogen, A alpha polypeptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q28

Summary The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008].
Disorder

MIM: 134820

Dysfibrinogenemia, alpha type, causing bleeding diathesis (3);

mRNA Protein Product Sequence Price Select
NM_000508, 70906432 NP_000499, 4503689 fibrinogen alpha chain isoform alpha-E preproprotein ORF Sequence $750.00
NM_021871, 70906433 NP_068657, 11761629 fibrinogen alpha chain isoform alpha preproprotein ORF Sequence $700.00
KEGG
hsa04610Complement and coagulation cascades
hsa04611Platelet activation
WikiPathways
WP272Blood Clotting Cascade
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Integrins
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_278Platelet Aggregation (Plug Formation)
REACT_1439Common Pathway
REACT_13552Integrin cell surface interactions
REACT_15523Integrin alphaIIb beta3 signaling
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_75925Amyloids
REACT_111102Signal Transduction
REACT_116125Disease
REACT_118779Extracellular matrix organization
Homo sapiens (human)FGANP_000499.1
Pan troglodytes (chimpanzee)FGAXP_001136067.1
Macaca mulatta (Rhesus monkey)FGAXP_001088855.2
Canis lupus familiaris (dog)FGAXP_532697.2
Mus musculus (house mouse)FgaNP_001104518.1
Rattus norvegicus (Norway rat)FgaNP_001008724.1
Gallus gallus (chicken)FGANP_001258840.1
Danio rerio (zebrafish)fgaNP_001181918.1
Xenopus (Silurana) tropicalis (western clawed frog)fgaXP_002933535.2
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0007160cell-matrix adhesionIDA
GO:0007165signal transductionIEA
GO:0007596blood coagulationTAS
GO:0030168platelet activationTAS
GO:0030198extracellular matrix organizationTAS
GO:0034116positive regulation of heterotypic cell-cell adhesionIDA
GO:0043623cellular protein complex assemblyIDA
GO:0045907positive regulation of vasoconstrictionIDA
GO:0045921positive regulation of exocytosisIDA
GO:0050714positive regulation of protein secretionIDA
GO:0051258protein polymerizationIDA
GO:0051592response to calcium ionIDA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDA
GO:0070527platelet aggregationIDA
GO:0072377blood coagulation, common pathwayIMP
GO:0090277positive regulation of peptide hormone secretionIDA
GO:1900026positive regulation of substrate adhesion-dependent cell spreadingNAS
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIDA
GO:2000261negative regulation of blood coagulation, common pathwayTAS
GO:2000352negative regulation of endothelial cell apoptotic processIDA
Component
IDNameEvidence
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005577fibrinogen complexIDA
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneTAS
GO:0005938cell cortexIEA
GO:0009897external side of plasma membraneIDA
GO:0009986cell surfaceIDA
GO:0031091platelet alpha granuleIDA
GO:0031093platelet alpha granule lumenTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0005102receptor bindingIDA
GO:0005198structural molecule activityIDA
GO:0005198structural molecule activityIMP
GO:0005515protein bindingIPI
GO:0030674protein binding, bridgingIEA
GO:0050839cell adhesion molecule bindingIDA
GeneCards FGA
UniProt P02671
Vega OTTHUMG00000150330
MIM 134820
Ensembl ENSG00000171560
HGNC 3661
HPRD 00619

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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