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Sequence in raw or FASTA format:


Blast Method:


FGB fibrinogen beta chain [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28452D NM_001184741 Homo sapiens fibrinogen beta chain (FGB), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK On-demand 7-9 Starting from $99
OHu28464D NM_005141 Homo sapiens fibrinogen beta chain (FGB), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu28452C NM_001184741 Homo sapiens fibrinogen beta chain (FGB), transcript variant 2, mRNA. Customized vector On-demand 7-9 Starting from $99
OHu28464C NM_005141 Homo sapiens fibrinogen beta chain (FGB), transcript variant 1, mRNA. Customized vector In-stock 5-7 Starting from $99

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Gene Symbol FGB
Entrez Gene ID 2244
Full Name fibrinogen beta chain
Synonyms HEL-S-78p
General protein information
Preferred Names
fibrinogen beta chain
fibrinogen beta chain
fibrinogen, B beta polypeptide
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014].

MIM: 134830

Dysfibrinogenemia, beta type (3); Afibrinogenemia, congenital,

mRNA Protein Product Sequence Price Select
NM_001184741, 296080753 NP_001171670, 296080754 fibrinogen beta chain isoform 2 preproprotein ORF Sequence $550.00
NM_005141, 296080752 NP_005132, 70906435 fibrinogen beta chain isoform 1 preproprotein ORF Sequence $360.00
hsa04610Complement and coagulation cascades
hsa04611Platelet activation
WP272Blood Clotting Cascade
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Integrins
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_278Platelet Aggregation (Plug Formation)
REACT_1439Common Pathway
REACT_13552Integrin cell surface interactions
REACT_15523Integrin alphaIIb beta3 signaling
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_111102Signal Transduction
REACT_118779Extracellular matrix organization
Homo sapiens (human)FGBNP_005132.2
Pan troglodytes (chimpanzee)FGBXP_517495.1
Macaca mulatta (Rhesus monkey)FGBXP_001091998.1
Canis lupus familiaris (dog)FGBXP_005629424.1
Bos taurus (cattle)FGBNP_001136389.1
Mus musculus (house mouse)FgbNP_862897.1
Rattus norvegicus (Norway rat)FgbNP_064456.2
Gallus gallus (chicken)FGBNP_001161155.1
Danio rerio (zebrafish)fgbNP_997939.1
Xenopus (Silurana) tropicalis (western clawed frog)fgbNP_001107962.1
GO:0002576platelet degranulationTAS
GO:0007160cell-matrix adhesionIDA
GO:0007165signal transductionIEA
GO:0007596blood coagulationTAS
GO:0030168platelet activationTAS
GO:0030198extracellular matrix organizationTAS
GO:0034116positive regulation of heterotypic cell-cell adhesionIDA
GO:0043623cellular protein complex assemblyIDA
GO:0044320cellular response to leptin stimulusIEA
GO:0045907positive regulation of vasoconstrictionIDA
GO:0045921positive regulation of exocytosisIDA
GO:0050714positive regulation of protein secretionIDA
GO:0051258protein polymerizationIDA
GO:0051592response to calcium ionIDA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDA
GO:0070527platelet aggregationIDA
GO:0071347cellular response to interleukin-1IEA
GO:0090277positive regulation of peptide hormone secretionIDA
GO:1900026positive regulation of substrate adhesion-dependent cell spreadingNAS
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIDA
GO:2000352negative regulation of endothelial cell apoptotic processIDA
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005577fibrinogen complexIDA
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneTAS
GO:0005938cell cortexIEA
GO:0009897external side of plasma membraneIDA
GO:0009986cell surfaceIDA
GO:0031091platelet alpha granuleIDA
GO:0031093platelet alpha granule lumenTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
GO:0005102receptor bindingIDA
GO:0005198structural molecule activityIDA
GO:0005515protein bindingIPI
GO:0030674protein binding, bridgingIEA
GO:0050839cell adhesion molecule bindingIDA
GO:0051087chaperone bindingIPI
GeneCards FGB
PDB 1RF1, 1FZB, 1LT9, 1FZC, 2Q9I, 1N8E, 3GHG, 2HPC, 2HLO, 1RE4, 1N86, 1RE3, 1FZA, 2XNX, 2A45, 1LTJ, 1FZG, 1FZF, 2FFD, 2OYH, 1FZE, 1RF0, 3E1I, 3BVH, 2OYI, 2H43, 2Z4E, 3HUS, 3H32, 2HOD, 2XNY
UniProt P02675, V9HVY1
MIM 134830
HGNC 3662
HPRD 00620

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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