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FGB fibrinogen beta chain [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001184741 Homo sapiens fibrinogen beta chain (FGB), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_005141 Homo sapiens fibrinogen beta chain (FGB), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Gene Symbol FGB
Entrez Gene ID 2244
Full Name fibrinogen beta chain
Synonyms MGC104327, MGC120405
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q28

Summary The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Jul 2008].
Disorder

MIM: 134830

Dysfibrinogenemia, beta type (3); Afibrinogenemia, congenital,

mRNA Protein Product Sequence Price Select
NM_001184741, 296080753 NP_001171670, 296080754 fibrinogen beta chain isoform 2 preproprotein ORF Sequence $550.00
NM_005141, 296080752 NP_005132, 70906435 fibrinogen beta chain isoform 1 preproprotein ORF Sequence $360.00
KEGG
hsa04610Complement and coagulation cascades
WikiPathways
WP558Complement and Coagulation Cascades
WP272Blood Clotting Cascade
Reactome
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_604Hemostasis
REACT_798Platelet activation, signaling and aggregation
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_318Platelet degranulation
REACT_111102Signal Transduction
REACT_1439Common Pathway
REACT_13552Integrin cell surface interactions
REACT_278Platelet Aggregation (Plug Formation)
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Intergrins
REACT_15523Integrin alphaIIb beta3 signaling
Homo sapiens (human)FGBNP_005132.2
Pan troglodytes (chimpanzee)FGBXP_517495.1
Macaca mulatta (Rhesus monkey)FGBXP_001091998.1
Canis lupus familiaris (dog)FGBXP_853738.1
Bos taurus (cattle)FGBNP_001136389.1
Mus musculus (house mouse)FgbNP_862897.1
Rattus norvegicus (Norway rat)FgbNP_064456.2
Gallus gallus (chicken)FGBNP_001161155.1
Danio rerio (zebrafish)fgbNP_997939.1
GeneCards FGB
PDB 1RF1, 1FZB, 1LT9, 1FZC, 2Q9I, 1N8E, 3GHG, 2HPC, 2HLO, 1RE4, 1N86, 1RE3, 1FZA, 2XNX, 2A45, 1LTJ, 1FZG, 1FZF, 2FFD, 2OYH, 1FZE, 1RF0, 3E1I, 3BVH, 2OYI, 2H43, 2Z4E, 3HUS, 3H32, 2HOD, 2XNY
UniProt P02675
MIM 134830
Ensembl ENSG00000171564
HGNC 3662
HPRD 00620

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
fibrinogen beta chain
Names
fibrinogen beta chain
fibrinogen, B beta polypeptide

Interactant



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