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FGF3 fibroblast growth factor 3 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_005247 Homo sapiens fibroblast growth factor 3 (FGF3), mRNA. ORF Sequence $208.80
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Gene Symbol FGF3
Entrez Gene ID 2248
Full Name fibroblast growth factor 3
Synonyms HBGF-3, INT2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13

Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008].
Disorder

MIM: 164950

Deafness, congenital with inner ear agenesis, microtia, and

mRNA Protein Product Sequence Price Select
NM_005247, 15451899 NP_005238, 4885233 fibroblast growth factor 3 precursor Full Length $448.92
ORF Sequence $208.80
KEGG
hsa04151PI3K-Akt signaling pathway
hsa05218Melanoma
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
WikiPathways
WP51Regulation of Actin Cytoskeleton
Reactome
REACT_121155Signaling by FGFR2 mutants
REACT_6802Innate Immune System
REACT_115871Signaling by EGFR in Cancer
REACT_147814DAP12 signaling
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_1195Insulin receptor signalling cascade
REACT_9417Signaling by EGFR
REACT_9396FGFR ligand binding and activation
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_147723PI3K/AKT Signaling in Cancer
REACT_121398Signaling by FGFR mutants
REACT_9483FGFR1 ligand binding and activation
REACT_115755Signaling by ERBB2
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_115596Signaling by ERBB4
REACT_21270PI-3K cascade
REACT_120736Signaling by FGFR in disease
REACT_21247FRS2-mediated cascade
REACT_147694DAP12 interactions
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_120863Activated point mutants of FGFR2
REACT_6900Immune System
REACT_111040Signaling by SCF-KIT
REACT_9400FGFR1b ligand binding and activation
REACT_21374SHC-mediated cascade
REACT_115961PI3K events in ERBB4 signaling
REACT_9390FGFR2 ligand binding and activation
REACT_498Signaling by Insulin receptor
REACT_12464PI3K/AKT activation
REACT_762IRS-related events
REACT_332IRS-mediated signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_111184Negative regulation of FGFR signaling
REACT_116008PI3K events in ERBB2 signaling
REACT_111102Signal Transduction
REACT_75829PIP3 activates AKT signaling
REACT_976PI3K Cascade
REACT_12578GAB1 signalosome
REACT_75774Adaptive Immune System
REACT_16888Signaling by PDGF
REACT_21310Phospholipase C-mediated cascade
REACT_9416FGFR2b ligand binding and activation
REACT_9470Signaling by FGFR
Homo sapiens (human)FGF3NP_005238.1
Pan troglodytes (chimpanzee)FGF3XP_522092.2
Macaca mulatta (Rhesus monkey)FGF3XP_001100658.1
Bos taurus (cattle)FGF3XP_002699485.1
Mus musculus (house mouse)Fgf3NP_032033.2
Rattus norvegicus (Norway rat)Fgf3NP_570830.1
Gallus gallus (chicken)FGF3NP_990658.1
Danio rerio (zebrafish)fgf3NP_571366.1
GeneCards FGF3
UniProt P11487
MIM 164950
Ensembl ENSG00000186895
HGNC 3681
HPRD 01289

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
fibroblast growth factor 3
Names
fibroblast growth factor 3
FGF-3
oncogene INT2
proto-oncogene Int-2
INT-2 proto-oncogene protein
heparin-binding growth factor 3
murine mammary tumor virus integration site 2, mouse
V-INT2 murine mammary tumor virus integration site oncogene homolog
fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)

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