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FGF3 fibroblast growth factor 3 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18680 NM_005247 Homo sapiens fibroblast growth factor 3 (FGF3), mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu18680C NM_005247 Homo sapiens fibroblast growth factor 3 (FGF3), mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol FGF3
Entrez Gene ID 2248
Full Name fibroblast growth factor 3
Synonyms HBGF-3, INT2
General protein information
Preferred Names
fibroblast growth factor 3
Names
fibroblast growth factor 3
FGF-3
oncogene INT2
proto-oncogene Int-2
INT-2 proto-oncogene protein
heparin-binding growth factor 3
murine mammary tumor virus integration site 2, mouse
V-INT2 murine mammary tumor virus integration site oncogene homolog
fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13

Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008].
Disorder

MIM: 164950

Deafness, congenital with inner ear agenesis, microtia, and

mRNA Protein Product Sequence Price Select
NM_005247, 15451899 NP_005238, 4885233 fibroblast growth factor 3 precursor ORF Sequence $250.00
KEGG
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
hsa05205Proteoglycans in cancer
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WikiPathways
WP51Regulation of Actin Cytoskeleton
Reactome
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_9396FGFR ligand binding and activation
REACT_9483FGFR1 ligand binding and activation
REACT_9416FGFR2b ligand binding and activation
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_976PI3K Cascade
REACT_762IRS-related events
REACT_11061Signalling by NGF
REACT_1195Insulin receptor signalling cascade
REACT_12464PI3K/AKT activation
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_9400FGFR1b ligand binding and activation
REACT_9390FGFR2 ligand binding and activation
REACT_21272Downstream signaling of activated FGFR
REACT_21310Phospholipase C-mediated cascade
REACT_21270PI-3K cascade
REACT_21247FRS2-mediated cascade
REACT_21374SHC-mediated cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111102Signal Transduction
REACT_111184Negative regulation of FGFR signaling
REACT_111040Signaling by SCF-KIT
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115596Signaling by ERBB4
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_121155Signaling by FGFR2 mutants
REACT_120863Activated point mutants of FGFR2
REACT_121398Signaling by FGFR mutants
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
Homo sapiens (human)FGF3NP_005238.1
Pan troglodytes (chimpanzee)FGF3XP_522092.2
Macaca mulatta (Rhesus monkey)FGF3XP_001100658.1
Bos taurus (cattle)FGF3XP_002699485.1
Mus musculus (house mouse)Fgf3NP_032033.2
Rattus norvegicus (Norway rat)Fgf3NP_570830.1
Gallus gallus (chicken)FGF3NP_990658.1
Danio rerio (zebrafish)fgf3NP_571366.1
Xenopus (Silurana) tropicalis (western clawed frog)fgf3NP_001008154.1
Process
IDNameEvidence
GO:0001759organ inductionIEA
GO:0007165signal transductionTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007267cell-cell signalingTAS
GO:0008284positive regulation of cell proliferationIGI
GO:0008286insulin receptor signaling pathwayTAS
GO:0008543fibroblast growth factor receptor signaling pathwayIGI
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0009653anatomical structure morphogenesisTAS
GO:0030916otic vesicle formationIEA
GO:0036342post-anal tail morphogenesisIEA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0045087innate immune responseTAS
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048538thymus developmentIEA
GO:0048752semicircular canal morphogenesisIEA
GO:0051781positive regulation of cell divisionIEA
GO:0055026negative regulation of cardiac muscle tissue developmentIMP
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005794Golgi apparatusIEA
Function
IDNameEvidence
GO:0005104fibroblast growth factor receptor bindingIEA
GO:0005515protein bindingIPI
GO:0008083growth factor activityIEA
GeneCards FGF3
UniProt P11487
MIM 164950
HGNC 3681
HPRD 01289

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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