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FGF3 fibroblast growth factor 3 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_005247 Homo sapiens fibroblast growth factor 3 (FGF3), mRNA. Full Length $448.92
ORF Sequence $208.80


Gene Symbol FGF3
Entrez Gene ID 2248
Full Name fibroblast growth factor 3
Synonyms HBGF-3, INT2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq].
Disorder

MIM: 164950

Deafness, congenital with inner ear agenesis, microtia, and
mRNA NM_005247, 15451899
Protein NP_005238, 4885233
Product fibroblast growth factor 3 precursor
RefSeq Status REVIEWED
KEGG
hsa05218Melanoma
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway
WikiPathways
WP51Regulation of Actin Cytoskeleton
Reactome
REACT_21374SHC-mediated cascade
REACT_9390FGFR2 ligand binding and activation
REACT_9396FGFR ligand binding and activation
REACT_9508FGFR3b ligand binding and activation
REACT_9413FGFR2c ligand binding and activation
REACT_9452FGFR4 ligand binding and activation
REACT_21270PI-3K cascade
REACT_498Signaling by Insulin receptor
REACT_9400FGFR1b ligand binding and activation
REACT_762IRS-related events
REACT_332IRS-mediated signalling
REACT_9439FGFR3 ligand binding and activation
REACT_21272Downstream signaling of activated FGFR
REACT_976PI3K Cascade
REACT_21310Phospholipase C-mediated cascade
REACT_9484FGFR1c and Klotho ligand binding and activation
REACT_9416FGFR2b ligand binding and activation
REACT_9470Signaling by FGFR
REACT_9483FGFR1 ligand binding and activation
REACT_9515FGFR1c ligand binding and activation
REACT_9510FGFR3c ligand binding and activation
REACT_21247FRS2-mediated cascade
REACT_1195Insulin receptor signalling cascade
Homo sapiens (human)FGF3NP_005238.1
Pan troglodytes (chimpanzee)FGF3XP_522092.2
Bos taurus (cattle)FGF3XP_875907.2
Mus musculus (house mouse)Fgf3NP_032033.1
Rattus norvegicus (Norway rat)Fgf3NP_570830.1
Gallus gallus (chicken)FGF3NP_990658.1
Danio rerio (zebrafish)LOC100334813XP_002662963.1
Danio rerio (zebrafish)fgf3NP_571366.1
Danio rerio (zebrafish)LOC100334683XP_002662961.1
Danio rerio (zebrafish)LOC100329292XP_002662967.1
Process
IDNameEvidence
GO:0001759organ inductionIEA
GO:0007165signal transductionTAS
GO:0007267cell-cell signalingTAS
GO:0008284positive regulation of cell proliferationIGI
GO:0008286insulin receptor signaling pathwayTAS
GO:0008543fibroblast growth factor receptor signaling pathwayEXP
GO:0008543fibroblast growth factor receptor signaling pathwayIGI
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0009653anatomical structure morphogenesisTAS
GO:0030916otic vesicle formationIEA
GO:0035121tail morphogenesisIEA
GO:0048538thymus developmentIEA
GO:0048752semicircular canal morphogenesisIEA
GO:0051781positive regulation of cell divisionIEA
GO:0055026negative regulation of cardiac muscle tissue developmentIMP
Component
IDNameEvidence
GO:0005576extracellular regionEXP
GO:0005576extracellular regionTAS
GO:0005737cytoplasmIEA
GO:0005794Golgi apparatusIEA
Function
IDNameEvidence
GO:0008083growth factor activityIEA
GeneCards FGF3
UniProt P11487
MIM 164950
Ensembl ENSG00000186895
HGNC 3681
HPRD 01289

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