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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


FGFR1 fibroblast growth factor receptor 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu23124 NM_001174067 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 14, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26578 NM_001174064 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 11, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26592 NM_001174065 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 12, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26609 NM_001174063 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 10, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26680 NM_023110 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26700 NM_001174066 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 13, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26768 NM_023106 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26700 NM_023105 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26592 NM_015850 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42016 XM_006716303 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42016 XM_006716304 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42016 XM_006716305 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42017 XM_006716306 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42017 XM_006716307 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42018 XM_006716308 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42019 XM_006716309 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X7, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42020 XM_006716310 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X8, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42020 XM_006716311 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X9, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42020 XM_006716312 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X10, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42021 XM_006716313 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X11, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu42021 XM_006716314 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X12, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu23124C NM_001174067 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 14, mRNA. Customized vector On-demand 12-14 $329.00
OHu26578C NM_001174064 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 11, mRNA. Customized vector On-demand 12-14 $329.00
OHu26592C NM_001174065 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 12, mRNA. Customized vector On-demand 12-14 $329.00
OHu26609C NM_001174063 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 10, mRNA. Customized vector On-demand 12-14 $329.00
OHu26680C NM_023110 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00
OHu26700C NM_001174066 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 13, mRNA. Customized vector On-demand 12-14 $329.00
OHu26768C NM_023106 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 4, mRNA. Customized vector On-demand 12-14 $329.00
OHu26700C NM_023105 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 3, mRNA. Customized vector On-demand 12-14 $329.00
OHu26592C NM_015850 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 2, mRNA. Customized vector On-demand 12-14 $329.00
OHu42016C XM_006716303 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu42016C XM_006716304 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00
OHu42016C XM_006716305 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X3, mRNA. Customized vector On-demand 12-14 $329.00
OHu42017C XM_006716306 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X4, mRNA. Customized vector On-demand 12-14 $329.00
OHu42017C XM_006716307 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X5, mRNA. Customized vector On-demand 12-14 $329.00
OHu42018C XM_006716308 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X6, mRNA. Customized vector On-demand 12-14 $329.00
OHu42019C XM_006716309 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X7, mRNA. Customized vector On-demand 12-14 $329.00
OHu42020C XM_006716310 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X8, mRNA. Customized vector On-demand 12-14 $329.00
OHu42020C XM_006716311 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X9, mRNA. Customized vector On-demand 12-14 $329.00
OHu42020C XM_006716312 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X10, mRNA. Customized vector On-demand 12-14 $329.00
OHu42021C XM_006716313 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X11, mRNA. Customized vector On-demand 12-14 $329.00
OHu42021C XM_006716314 PREDICTED: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant X12, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol FGFR1
Entrez Gene ID 2260
Full Name fibroblast growth factor receptor 1
Synonyms BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p11.23-p11.22

Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 136350

Pfeiffer syndrome, 101600 (3); Jackson-Weiss syndrome, 123150 (3);

mRNA Protein Product Sequence Price Select
NM_001174063, 291327488 NP_001167534, 291327489 fibroblast growth factor receptor 1 isoform 10 precursor ORF Sequence $750.00
NM_001174064, 291327490 NP_001167535, 291327491 fibroblast growth factor receptor 1 isoform 11 precursor ORF Sequence $750.00
NM_001174065, 291327492 NP_001167536, 291327493 fibroblast growth factor receptor 1 isoform 2 precursor ORF Sequence $750.00
NM_001174066, 291327494 NP_001167537, 291327495 fibroblast growth factor receptor 1 isoform 3 precursor ORF Sequence $700.00
NM_001174067, 291327496 NP_001167538, 291327497 fibroblast growth factor receptor 1 isoform 14 precursor ORF Sequence $750.00
NM_015850, 105990515 NP_056934, 13186251 fibroblast growth factor receptor 1 isoform 2 precursor ORF Sequence $750.00
NM_023105, 105990517 NP_075593, 13186234 fibroblast growth factor receptor 1 isoform 3 precursor ORF Sequence $700.00
NM_023106, 105990516 NP_075594, 13186236 fibroblast growth factor receptor 1 isoform 4 precursor ORF Sequence $700.00
NM_023110, 105990521 NP_075598, 105990522 fibroblast growth factor receptor 1 isoform 1 precursor ORF Sequence $750.00
XM_006716303, 578815230 XP_006716366, 578815231 fibroblast growth factor receptor 1 isoform X1 ORF Sequence $750.00
XM_006716304, 578815232 XP_006716367, 578815233 fibroblast growth factor receptor 1 isoform X2 ORF Sequence $750.00
XM_006716305, 578815234 XP_006716368, 578815235 fibroblast growth factor receptor 1 isoform X3 ORF Sequence $750.00
XM_006716306, 578815236 XP_006716369, 578815237 fibroblast growth factor receptor 1 isoform X4 ORF Sequence $750.00
XM_006716307, 578815238 XP_006716370, 578815239 fibroblast growth factor receptor 1 isoform X5 ORF Sequence $750.00
XM_006716308, 578815240 XP_006716371, 578815241 fibroblast growth factor receptor 1 isoform X6 ORF Sequence $750.00
XM_006716309, 578815242 XP_006716372, 578815243 fibroblast growth factor receptor 1 isoform X7 ORF Sequence $750.00
XM_006716310, 578815244 XP_006716373, 578815245 fibroblast growth factor receptor 1 isoform X8 ORF Sequence $700.00
XM_006716311, 578815246 XP_006716374, 578815247 fibroblast growth factor receptor 1 isoform X9 ORF Sequence $700.00
XM_006716312, 578815248 XP_006716375, 578815249 fibroblast growth factor receptor 1 isoform X10 ORF Sequence $700.00
XM_006716313, 578815250 XP_006716376, 578815251 fibroblast growth factor receptor 1 isoform X11 ORF Sequence $700.00
XM_006716314, 578815252 XP_006716377, 578815253 fibroblast growth factor receptor 1 isoform X12 ORF Sequence $700.00
KEGG
hsa04010MAPK signaling pathway
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05215Prostate cancer
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
hsa05205Proteoglycans in cancer
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WikiPathways
WP474Endochondral Ossification
WP51Regulation of Actin Cytoskeleton
WP2377Integrated Pancreatic Cancer Pathway
WP2261Signaling Pathways in Glioblastoma
WP2064Neural Crest Differentiation
Pathway Interaction Database
fgf_pathwayFGF signaling pathway
ncadherinpathwayN-cadherin signaling events
glypican_1pathwayGlypican 1 network
syndecan_4_pathwaySyndecan-4-mediated signaling events
Reactome
REACT_18266Axon guidance
REACT_18334NCAM signaling for neurite out-growth
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_9396FGFR ligand binding and activation
REACT_9483FGFR1 ligand binding and activation
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_9515FGFR1c ligand binding and activation
REACT_9484FGFR1c and Klotho ligand binding and activation
REACT_976PI3K Cascade
REACT_762IRS-related events
REACT_11061Signalling by NGF
REACT_1195Insulin receptor signalling cascade
REACT_12464PI3K/AKT activation
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21272Downstream signaling of activated FGFR
REACT_21310Phospholipase C-mediated cascade
REACT_21270PI-3K cascade
REACT_21247FRS2-mediated cascade
REACT_21374SHC-mediated cascade
REACT_22205L1CAM interactions
REACT_22272Signal transduction by L1
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111102Signal Transduction
REACT_111045Developmental Biology
REACT_111247Klotho-mediated ligand binding
REACT_111184Negative regulation of FGFR signaling
REACT_111040Signaling by SCF-KIT
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115596Signaling by ERBB4
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_121153Signaling by activated point mutants of FGFR1
REACT_120827Signaling by FGFR1 amplification mutants
REACT_121398Signaling by FGFR mutants
REACT_120999Signaling by FGFR1 mutants
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
Homo sapiens (human)FGFR1NP_001167538.1
Pan troglodytes (chimpanzee)FGFR1XP_001171131.1
Canis lupus familiaris (dog)FGFR1XP_005629905.1
Bos taurus (cattle)FGFR1NP_001103677.1
Mus musculus (house mouse)Fgfr1NP_034336.2
Rattus norvegicus (Norway rat)Fgfr1NP_077060.1
Gallus gallus (chicken)FGFR1NP_990841.1
Danio rerio (zebrafish)fgfr1aNP_694494.1
Xenopus (Silurana) tropicalis (western clawed frog)fgfr1NP_001015894.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0000165MAPK cascadeTAS
GO:0001501skeletal system developmentTAS
GO:0001525angiogenesisIEA
GO:0001657ureteric bud developmentIEA
GO:0001701in utero embryonic developmentIEA
GO:0001759organ inductionIEA
GO:0001764neuron migrationTAS
GO:0002053positive regulation of mesenchymal cell proliferationIEA
GO:0002062chondrocyte differentiationIEA
GO:0006351transcription, DNA-templatedIEA
GO:0006468protein phosphorylationNAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007411axon guidanceTAS
GO:0007605sensory perception of soundIEA
GO:0008284positive regulation of cell proliferationIDA
GO:0008284positive regulation of cell proliferationIGI
GO:0008284positive regulation of cell proliferationIMP
GO:0008286insulin receptor signaling pathwayTAS
GO:0008543fibroblast growth factor receptor signaling pathwayIDA
GO:0008543fibroblast growth factor receptor signaling pathwayIGI
GO:0008543fibroblast growth factor receptor signaling pathwayIPI
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0010518positive regulation of phospholipase activityTAS
GO:0010863positive regulation of phospholipase C activityIDA
GO:0010976positive regulation of neuron projection developmentIEA
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingTAS
GO:0016477cell migrationTAS
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0021847ventricular zone neuroblast divisionIEA
GO:0030326embryonic limb morphogenesisIEA
GO:0030901midbrain developmentIEA
GO:0035607fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentIEA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042472inner ear morphogenesisIEA
GO:0042473outer ear morphogenesisIEA
GO:0042474middle ear morphogenesisIEA
GO:0043009chordate embryonic developmentTAS
GO:0043406positive regulation of MAP kinase activityIDA
GO:0043410positive regulation of MAPK cascadeIMP
GO:0045087innate immune responseTAS
GO:0045595regulation of cell differentiationTAS
GO:0045666positive regulation of neuron differentiationIMP
GO:0045787positive regulation of cell cycleIEA
GO:0046777protein autophosphorylationIDA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048339paraxial mesoderm developmentIEA
GO:0048378regulation of lateral mesodermal cell fate specificationIEA
GO:0048469cell maturationIEA
GO:0048705skeletal system morphogenesisTAS
GO:0048762mesenchymal cell differentiationIEA
GO:0060045positive regulation of cardiac muscle cell proliferationIEA
GO:0060117auditory receptor cell developmentIEA
GO:0060445branching involved in salivary gland morphogenesisIEA
GO:0060484lung-associated mesenchyme developmentIEA
GO:0060665regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingIEA
GO:0090080positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayIEA
GO:2001239regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA
Component
IDNameEvidence
GO:0005576extracellular regionNAS
GO:0005634nucleusIEA
GO:0005829cytosolIEA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0016021integral component of membraneNAS
GO:0016023cytoplasmic membrane-bounded vesicleIEA
GO:0043235receptor complexIDA
Function
IDNameEvidence
GO:0004713protein tyrosine kinase activityIDA
GO:0005007fibroblast growth factor-activated receptor activityIDA
GO:0005007fibroblast growth factor-activated receptor activityTAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0008201heparin bindingIDA
GO:0017134fibroblast growth factor bindingIDA
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIPI
GeneCards FGFR1
UniProt P11362
Vega OTTHUMG00000147366
MIM 136350
Ensembl ENSG00000077782
HGNC 3688
HPRD 00634

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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