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FGFR1 fibroblast growth factor receptor 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001174063 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 10, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001174064 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 11, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001174065 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 12, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001174066 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 13, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001174067 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 14, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_015850 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_023105 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_023106 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_023110 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol FGFR1
Entrez Gene ID 2260
Full Name fibroblast growth factor receptor 1
Synonyms BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLJ99988, FLT-2, FLT2, HBGFR, KAL2, N-SAM, OGD, bFGF-R-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p12

Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 136350

Pfeiffer syndrome, 101600 (3); Jackson-Weiss syndrome, 123150 (3);

mRNA Protein Product Sequence Price Select
NM_001174063, 291327488 NP_001167534, 291327489 fibroblast growth factor receptor 1 isoform 10 precursor ORF Sequence $750.00
NM_001174064, 291327490 NP_001167535, 291327491 fibroblast growth factor receptor 1 isoform 11 precursor ORF Sequence $750.00
NM_001174065, 291327492 NP_001167536, 291327493 fibroblast growth factor receptor 1 isoform 2 precursor ORF Sequence $750.00
NM_001174066, 291327494 NP_001167537, 291327495 fibroblast growth factor receptor 1 isoform 3 precursor ORF Sequence $700.00
NM_001174067, 291327496 NP_001167538, 291327497 fibroblast growth factor receptor 1 isoform 14 precursor ORF Sequence $750.00
NM_015850, 105990515 NP_056934, 13186251 fibroblast growth factor receptor 1 isoform 2 precursor ORF Sequence $750.00
NM_023105, 105990517 NP_075593, 13186234 fibroblast growth factor receptor 1 isoform 3 precursor ORF Sequence $700.00
NM_023106, 105990516 NP_075594, 13186236 fibroblast growth factor receptor 1 isoform 4 precursor ORF Sequence $700.00
NM_023110, 105990521 NP_075598, 105990522 fibroblast growth factor receptor 1 isoform 1 precursor ORF Sequence $750.00
KEGG
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa04520Adherens junction
hsa04010MAPK signaling pathway
hsa05215Prostate cancer
hsa04151PI3K-Akt signaling pathway
hsa05218Melanoma
Pathway Interaction Database
glypican_1pathwayGlypican 1 network
syndecan_4_pathwaySyndecan-4-mediated signaling events
ncadherinpathwayN-cadherin signaling events
fgf_pathwayFGF signaling pathway
WikiPathways
WP474Endochondral Ossification
WP2256Integrated Pancreatic Cancer Pathway
WP2064Neural Crest Differentiation
WP2261Signaling Pathways in Glioblastoma
WP2377Integrated Pancreatic Cancer Pathway
WP51Regulation of Actin Cytoskeleton
Reactome
REACT_111102Signal Transduction
REACT_21374SHC-mediated cascade
REACT_332IRS-mediated signalling
REACT_22205L1CAM interactions
REACT_111247Klotho-mediated ligand binding
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_21247FRS2-mediated cascade
REACT_75829PIP3 activates AKT signaling
REACT_116125Disease
REACT_116008PI3K events in ERBB2 signaling
REACT_17025Downstream signal transduction
REACT_18334NCAM signaling for neurite out-growth
REACT_21310Phospholipase C-mediated cascade
REACT_9470Signaling by FGFR
REACT_498Signaling by Insulin receptor
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_120999Signaling by FGFR1 mutants
REACT_976PI3K Cascade
REACT_147723PI3K/AKT Signaling in Cancer
REACT_762IRS-related events
REACT_18266Axon guidance
REACT_12578GAB1 signalosome
REACT_12464PI3K/AKT activation
REACT_21272Downstream signaling of activated FGFR
REACT_16888Signaling by PDGF
REACT_9417Signaling by EGFR
REACT_121153Signaling by activated point mutants of FGFR1
REACT_6802Innate Immune System
REACT_147814DAP12 signaling
REACT_111184Negative regulation of FGFR signaling
REACT_120827Signaling by FGFR1 amplification mutants
REACT_120736Signaling by FGFR in disease
REACT_11061Signalling by NGF
REACT_9396FGFR ligand binding and activation
REACT_75774Adaptive Immune System
REACT_9484FGFR1c and Klotho ligand binding and activation
REACT_115961PI3K events in ERBB4 signaling
REACT_111045Developmental Biology
REACT_22272Signal transduction by L1
REACT_9483FGFR1 ligand binding and activation
REACT_9515FGFR1c ligand binding and activation
REACT_111040Signaling by SCF-KIT
REACT_21270PI-3K cascade
REACT_1195Insulin receptor signalling cascade
REACT_115871Signaling by EGFR in Cancer
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_115755Signaling by ERBB2
REACT_121398Signaling by FGFR mutants
REACT_115596Signaling by ERBB4
REACT_6900Immune System
REACT_147694DAP12 interactions
Homo sapiens (human)FGFR1NP_001167536.1
Pan troglodytes (chimpanzee)FGFR1XP_001171131.1
Canis lupus familiaris (dog)LOC100856477XP_003639610.1
Bos taurus (cattle)FGFR1NP_001103677.1
Mus musculus (house mouse)Fgfr1NP_034336.2
Rattus norvegicus (Norway rat)Fgfr1NP_077060.1
Gallus gallus (chicken)FGFR1NP_990841.1
Danio rerio (zebrafish)fgfr1aNP_694494.1
GeneCards FGFR1
PDB 1FGI, 3GQL, 3C4F, 1EVT, 3OJV, 3TT0, 3KRJ, 1AGW, 1FGK, 3KY2, 3GQI, 4F64, 3RHX, 3KXX, 1CVS, 3JS2, 2FGI, 3KRL, 4F65, 4F63, 1XR0, 1FQ9, 2CR3
UniProt P11362
MIM 136350
Ensembl ENSG00000077782
HGNC 3688
HPRD 00634

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

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