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FGFR3 fibroblast growth factor receptor 3 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000142 Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001163213 Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_022965 Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol FGFR3
Entrez Gene ID 2261
Full Name fibroblast growth factor receptor 3
Synonyms ACH, CD333, CEK2, HSFGFR3EX, JTK4
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009].

MIM: 134934

Achondroplasia, 100800 (3); Hypochondroplasia, 146000 (3); Thanatophoric dysplasia, type I, 187600 (3);

mRNA Protein Product Sequence Price Select
NM_000142, 254028235 NP_000133, 4503711 fibroblast growth factor receptor 3 isoform 1 precursor ORF Sequence $750.00
NM_001163213, 254028241 NP_001156685, 254028242 fibroblast growth factor receptor 3 isoform 3 precursor ORF Sequence $750.00
NM_022965, 254028238 NP_075254, 13112048 fibroblast growth factor receptor 3 isoform 2 precursor ORF Sequence $700.00
hsa05219Bladder cancer
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway
hsa04151PI3K-Akt signaling pathway
WP51Regulation of Actin Cytoskeleton
WP2064Neural Crest Differentiation
WP474Endochondral Ossification
REACT_121337Signaling by activated point mutants of FGFR3
REACT_111184Negative regulation of FGFR signaling
REACT_6900Immune System
REACT_111040Signaling by SCF-KIT
REACT_115961PI3K events in ERBB4 signaling
REACT_498Signaling by Insulin receptor
REACT_147694DAP12 interactions
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_976PI3K Cascade
REACT_115755Signaling by ERBB2
REACT_120736Signaling by FGFR in disease
REACT_21270PI-3K cascade
REACT_11061Signalling by NGF
REACT_1195Insulin receptor signalling cascade
REACT_9508FGFR3b ligand binding and activation
REACT_9396FGFR ligand binding and activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_762IRS-related events
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_9439FGFR3 ligand binding and activation
REACT_12464PI3K/AKT activation
REACT_115871Signaling by EGFR in Cancer
REACT_332IRS-mediated signalling
REACT_9510FGFR3c ligand binding and activation
REACT_17025Downstream signal transduction
REACT_9417Signaling by EGFR
REACT_6802Innate Immune System
REACT_147814DAP12 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_21374SHC-mediated cascade
REACT_75829PIP3 activates AKT signaling
REACT_121398Signaling by FGFR mutants
REACT_21247FRS2-mediated cascade
REACT_75774Adaptive Immune System
REACT_16888Signaling by PDGF
REACT_12578GAB1 signalosome
REACT_21310Phospholipase C-mediated cascade
REACT_121249Signaling by FGFR3 mutants
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21272Downstream signaling of activated FGFR
REACT_121011t(4;14) translocations of FGFR3
REACT_116008PI3K events in ERBB2 signaling
REACT_111102Signal Transduction
Homo sapiens (human)FGFR3NP_001156685.1
Pan troglodytes (chimpanzee)FGFR3XP_003310269.1
Macaca mulatta (Rhesus monkey)FGFR3XP_002802213.1
Canis lupus familiaris (dog)FGFR3XP_545926.3
Bos taurus (cattle)FGFR3NP_776743.1
Mus musculus (house mouse)Fgfr3NP_001192199.1
Rattus norvegicus (Norway rat)Fgfr3NP_445881.1
Gallus gallus (chicken)FGFR3NP_990840.2
Danio rerio (zebrafish)fgfr3NP_571681.1
Caenorhabditis elegansegl-15NP_001024723.1
GeneCards FGFR3
UniProt P22607, Q0IJ44
MIM 134934
Ensembl ENSG00000068078
HGNC 3690
HPRD 00624

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
fibroblast growth factor receptor 3
fibroblast growth factor receptor 3
tyrosine kinase JTK4
hydroxyaryl-protein kinase
fibroblast growth factor receptor 3 variant 4


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