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FGFR2 fibroblast growth factor receptor 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000141 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_001144913 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001144914 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001144915 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001144916 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001144917 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001144918 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001144919 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_022970 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_023029 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 11, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

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Gene Symbol FGFR2
Entrez Gene ID 2263
Full Name fibroblast growth factor receptor 2
Synonyms BEK, BFR-1, CD332, CEK3, CFD1, ECT1, FLJ98662, JWS, K-SAM, KGFR, TK14, TK25
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q26

Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].
Disorder

MIM: 176943

Crouzon syndrome, 123500 (3); Jackson-Weiss syndrome, 123150 (3); Beare-Stevenson cutis gyrata syndrome, 123790 (3); Pfeiffer syndrome, 101600

mRNA Protein Product Sequence Price Select
NM_000141, 189083823 NP_000132, 221316639 fibroblast growth factor receptor 2 isoform 1 precursor ORF Sequence $660.00
NM_001144913, 222144230 NP_001138385, 222144231 fibroblast growth factor receptor 2 isoform 3 precursor ORF Sequence $750.00
NM_001144914, 222144232 NP_001138386, 222144233 fibroblast growth factor receptor 2 isoform 4 precursor ORF Sequence $700.00
NM_001144915, 222144234 NP_001138387, 222144235 fibroblast growth factor receptor 2 isoform 5 precursor ORF Sequence $700.00
NM_001144916, 222144236 NP_001138388, 222144237 fibroblast growth factor receptor 2 isoform 6 precursor ORF Sequence $700.00
NM_001144917, 222144238 NP_001138389, 222144239 fibroblast growth factor receptor 2 isoform 7 precursor ORF Sequence $700.00
NM_001144918, 222144240 NP_001138390, 222144241 fibroblast growth factor receptor 2 isoform 8 precursor ORF Sequence $700.00
NM_001144919, 222144243 NP_001138391, 222144244 fibroblast growth factor receptor 2 isoform 9 precursor ORF Sequence $700.00
NM_022970, 189083816 NP_075259, 221316638 fibroblast growth factor receptor 2 isoform 2 precursor ORF Sequence $750.00
NM_023029, 394025691 NP_075418, 13186243 fibroblast growth factor receptor 2 isoform 11 precursor ORF Sequence $700.00
KEGG
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway
hsa05215Prostate cancer
hsa04151PI3K-Akt signaling pathway
hsa04144Endocytosis
Pathway Interaction Database
fgf_pathwayFGF signaling pathway
WikiPathways
WP1539Angiogenesis
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP2064Neural Crest Differentiation
WP51Regulation of Actin Cytoskeleton
WP2261Signaling Pathways in Glioblastoma
Reactome
REACT_332IRS-mediated signalling
REACT_120863Activated point mutants of FGFR2
REACT_21374SHC-mediated cascade
REACT_9416FGFR2b ligand binding and activation
REACT_9470Signaling by FGFR
REACT_111102Signal Transduction
REACT_498Signaling by Insulin receptor
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21270PI-3K cascade
REACT_116125Disease
REACT_21310Phospholipase C-mediated cascade
REACT_17025Downstream signal transduction
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_6900Immune System
REACT_21247FRS2-mediated cascade
REACT_121155Signaling by FGFR2 mutants
REACT_9396FGFR ligand binding and activation
REACT_75829PIP3 activates AKT signaling
REACT_120736Signaling by FGFR in disease
REACT_147723PI3K/AKT Signaling in Cancer
REACT_1195Insulin receptor signalling cascade
REACT_115596Signaling by ERBB4
REACT_976PI3K Cascade
REACT_12578GAB1 signalosome
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116008PI3K events in ERBB2 signaling
REACT_6802Innate Immune System
REACT_9413FGFR2c ligand binding and activation
REACT_111184Negative regulation of FGFR signaling
REACT_11061Signalling by NGF
REACT_16888Signaling by PDGF
REACT_9417Signaling by EGFR
REACT_21272Downstream signaling of activated FGFR
REACT_75774Adaptive Immune System
REACT_115961PI3K events in ERBB4 signaling
REACT_762IRS-related events
REACT_9390FGFR2 ligand binding and activation
REACT_111040Signaling by SCF-KIT
REACT_121255Signaling by FGFR2 amplification mutants
REACT_115871Signaling by EGFR in Cancer
REACT_121398Signaling by FGFR mutants
REACT_115755Signaling by ERBB2
REACT_12464PI3K/AKT activation
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
Homo sapiens (human)FGFR2NP_000132.3
Pan troglodytes (chimpanzee)FGFR2XP_001157390.2
Canis lupus familiaris (dog)FGFR2NP_001003336.1
Bos taurus (cattle)FGFR2NP_001192239.1
Mus musculus (house mouse)Fgfr2NP_034337.2
Rattus norvegicus (Norway rat)Fgfr2NP_001103362.1
Gallus gallus (chicken)FGFR2NP_990650.1
Danio rerio (zebrafish)fgfr2NP_840088.1
Drosophila melanogaster (fruit fly)btlNP_729956.1
Drosophila melanogaster (fruit fly)htlNP_524394.2
GeneCards FGFR2
PDB 2FDB, 2PVY, 1NUN, 1E0O, 3CU1, 1GJO, 3CAF, 1IIL, 3CLY, 3DAR, 2Q0B, 2PZP, 2PWL, 2PY3, 3RI1, 3OJM, 2PZ5, 3B2T, 3EUU, 1OEC, 2PVF, 1DJS, 1II4, 1EV2, 2PZR, 3OJ2, 1WVZ, 2PSQ
UniProt P21802, D2CGD1
MIM 176943
Ensembl ENSG00000066468
HGNC 3689
HPRD 01492

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
fibroblast growth factor receptor 2
Names
fibroblast growth factor receptor 2
FGFR-2
FGF receptor
soluble FGFR4 variant 4
bacteria-expressed kinase
hydroxyaryl-protein kinase
keratinocyte growth factor receptor
BEK fibroblast growth factor receptor
protein tyrosine kinase, receptor like 14
NP_000132.3
NP_001138385.1
NP_001138386.1
NP_001138387.1
NP_001138388.1
NP_001138389.1
NP_001138390.1
NP_001138391.1
NP_075259.4
NP_075418.1

Interactant



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