• THAT   AND
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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


FGFR2 fibroblast growth factor receptor 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22401 NM_001144919 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 9, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu22621 NM_023029 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 11, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu22945 NM_001144913 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26187 NM_001144916 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 6, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26260 NM_000141 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu26352 NM_001144915 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26708 NM_001144917 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 7, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu27093 NM_001144914 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu27162 NM_001144918 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 8, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu27185 NM_022970 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu44132 XM_006717708 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu44133 XM_006717709 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu44134 XM_006717710 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu44135 XM_006717711 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu44136 XM_006717712 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu44137 XM_006717713 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu22401C NM_001144919 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 9, mRNA. Customized vector On-demand 12-14 $329.00
OHu22621C NM_023029 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 11, mRNA. Customized vector On-demand 12-14 $329.00
OHu22945C NM_001144913 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 3, mRNA. Customized vector On-demand 12-14 $329.00
OHu26187C NM_001144916 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 6, mRNA. Customized vector On-demand 12-14 $329.00
OHu26260C NM_000141 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu26352C NM_001144915 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 5, mRNA. Customized vector On-demand 12-14 $329.00
OHu26708C NM_001144917 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 7, mRNA. Customized vector On-demand 12-14 $329.00
OHu27093C NM_001144914 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 4, mRNA. Customized vector On-demand 12-14 $329.00
OHu27162C NM_001144918 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 8, mRNA. Customized vector On-demand 12-14 $329.00
OHu27185C NM_022970 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 2, mRNA. Customized vector On-demand 12-14 $329.00
OHu44132C XM_006717708 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu44133C XM_006717709 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00
OHu44134C XM_006717710 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X3, mRNA. Customized vector On-demand 12-14 $329.00
OHu44135C XM_006717711 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X4, mRNA. Customized vector On-demand 12-14 $329.00
OHu44136C XM_006717712 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X5, mRNA. Customized vector On-demand 12-14 $329.00
OHu44137C XM_006717713 PREDICTED: Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant X6, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol FGFR2
Entrez Gene ID 2263
Full Name fibroblast growth factor receptor 2
Synonyms BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
General protein information
Preferred Names
fibroblast growth factor receptor 2
Names
fibroblast growth factor receptor 2
FGFR-2
FGF receptor
soluble FGFR4 variant 4
bacteria-expressed kinase
hydroxyaryl-protein kinase
keratinocyte growth factor receptor
BEK fibroblast growth factor receptor
protein tyrosine kinase, receptor like 14
NP_000132.3
NP_001138385.1
NP_001138386.1
NP_001138387.1
NP_001138388.1
NP_001138389.1
NP_001138390.1
NP_001138391.1
NP_075259.4
NP_075418.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q26

Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].
Disorder

MIM: 176943

Crouzon syndrome, 123500 (3); Jackson-Weiss syndrome, 123150 (3); Beare-Stevenson cutis gyrata syndrome, 123790 (3); Pfeiffer syndrome, 101600

mRNA Protein Product Sequence Price Select
NM_000141, 189083823 NP_000132, 221316639 fibroblast growth factor receptor 2 isoform 1 precursor ORF Sequence $660.00
NM_001144913, 222144230 NP_001138385, 222144231 fibroblast growth factor receptor 2 isoform 3 precursor ORF Sequence $750.00
NM_001144914, 222144232 NP_001138386, 222144233 fibroblast growth factor receptor 2 isoform 4 precursor ORF Sequence $700.00
NM_001144915, 222144234 NP_001138387, 222144235 fibroblast growth factor receptor 2 isoform 5 precursor ORF Sequence $700.00
NM_001144916, 222144236 NP_001138388, 222144237 fibroblast growth factor receptor 2 isoform 6 precursor ORF Sequence $700.00
NM_001144917, 222144238 NP_001138389, 222144239 fibroblast growth factor receptor 2 isoform 7 precursor ORF Sequence $700.00
NM_001144918, 222144240 NP_001138390, 222144241 fibroblast growth factor receptor 2 isoform 8 precursor ORF Sequence $700.00
NM_001144919, 222144243 NP_001138391, 222144244 fibroblast growth factor receptor 2 isoform 9 precursor ORF Sequence $700.00
NM_022970, 189083816 NP_075259, 221316638 fibroblast growth factor receptor 2 isoform 2 precursor ORF Sequence $750.00
NM_023029, 394025691 NP_075418, 13186243 fibroblast growth factor receptor 2 isoform 11 precursor ORF Sequence $700.00
XM_006717708, 578819114 XP_006717771, 578819115 fibroblast growth factor receptor 2 isoform X1 ORF Sequence $750.00
XM_006717709, 578819116 XP_006717772, 578819117 fibroblast growth factor receptor 2 isoform X2 ORF Sequence $750.00
XM_006717710, 578819118 XP_006717773, 578819119 fibroblast growth factor receptor 2 isoform X3 ORF Sequence $750.00
XM_006717711, 578819120 XP_006717774, 578819121 fibroblast growth factor receptor 2 isoform X4 ORF Sequence $700.00
XM_006717712, 578819122 XP_006717775, 578819123 fibroblast growth factor receptor 2 isoform X5 ORF Sequence $700.00
XM_006717713, 578819124 XP_006717776, 578819125 fibroblast growth factor receptor 2 isoform X6 ORF Sequence $750.00
KEGG
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05215Prostate cancer
hsa05200Pathways in cancer
hsa04144Endocytosis
hsa04151PI3K-Akt signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WikiPathways
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP51Regulation of Actin Cytoskeleton
WP2261Signaling Pathways in Glioblastoma
WP2064Neural Crest Differentiation
Pathway Interaction Database
fgf_pathwayFGF signaling pathway
Reactome
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_9396FGFR ligand binding and activation
REACT_9413FGFR2c ligand binding and activation
REACT_9416FGFR2b ligand binding and activation
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_976PI3K Cascade
REACT_762IRS-related events
REACT_11061Signalling by NGF
REACT_1195Insulin receptor signalling cascade
REACT_12464PI3K/AKT activation
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_9390FGFR2 ligand binding and activation
REACT_21272Downstream signaling of activated FGFR
REACT_21310Phospholipase C-mediated cascade
REACT_21270PI-3K cascade
REACT_21247FRS2-mediated cascade
REACT_21374SHC-mediated cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111102Signal Transduction
REACT_111184Negative regulation of FGFR signaling
REACT_111040Signaling by SCF-KIT
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115596Signaling by ERBB4
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_121155Signaling by FGFR2 mutants
REACT_120863Activated point mutants of FGFR2
REACT_121398Signaling by FGFR mutants
REACT_121255Signaling by FGFR2 amplification mutants
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
Homo sapiens (human)FGFR2NP_075259.4
Pan troglodytes (chimpanzee)FGFR2XP_001157390.2
Canis lupus familiaris (dog)FGFR2NP_001003336.1
Bos taurus (cattle)FGFR2NP_001192239.1
Mus musculus (house mouse)Fgfr2NP_034337.2
Rattus norvegicus (Norway rat)Fgfr2NP_001103362.1
Gallus gallus (chicken)FGFR2NP_990650.1
Danio rerio (zebrafish)fgfr2NP_001229933.1
Drosophila melanogaster (fruit fly)btlNP_001014583.1
Xenopus (Silurana) tropicalis (western clawed frog)fgfr2NP_001096326.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS
GO:0001525angiogenesisISS
GO:0001657ureteric bud developmentISS
GO:0001701in utero embryonic developmentISS
GO:0001837epithelial to mesenchymal transitionIEA
GO:0002053positive regulation of mesenchymal cell proliferationISS
GO:0003148outflow tract septum morphogenesisISS
GO:0003149membranous septum morphogenesisISS
GO:0006915apoptotic processIEA
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007267cell-cell signalingISS
GO:0007409axonogenesisISS
GO:0007528neuromuscular junction developmentIEA
GO:0008284positive regulation of cell proliferationIDA
GO:0008284positive regulation of cell proliferationIGI
GO:0008284positive regulation of cell proliferationIMP
GO:0008286insulin receptor signaling pathwayTAS
GO:0008543fibroblast growth factor receptor signaling pathwayIDA
GO:0008543fibroblast growth factor receptor signaling pathwayIGI
GO:0008543fibroblast growth factor receptor signaling pathwayIPI
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0008589regulation of smoothened signaling pathwayISS
GO:0009791post-embryonic developmentISS
GO:0009880embryonic pattern specificationISS
GO:0009887organ morphogenesisISS
GO:0010453regulation of cell fate commitmentISS
GO:0010518positive regulation of phospholipase activityIMP
GO:0016331morphogenesis of embryonic epitheliumISS
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0021769orbitofrontal cortex developmentISS
GO:0021847ventricular zone neuroblast divisionISS
GO:0021860pyramidal neuron developmentISS
GO:0022612gland morphogenesisISS
GO:0030177positive regulation of Wnt signaling pathwayISS
GO:0030282bone mineralizationISS
GO:0030324lung developmentISS
GO:0030855epithelial cell differentiationISS
GO:0030901midbrain developmentISS
GO:0030916otic vesicle formationISS
GO:0031069hair follicle morphogenesisISS
GO:0032808lacrimal gland developmentISS
GO:0033688regulation of osteoblast proliferationTAS
GO:0035264multicellular organism growthISS
GO:0035265organ growthISS
GO:0035602fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrowISS
GO:0035603fibroblast growth factor receptor signaling pathway involved in hemopoiesisISS
GO:0035604fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrowISS
GO:0035607fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentISS
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0040014regulation of multicellular organism growthISS
GO:0040036regulation of fibroblast growth factor receptor signaling pathwayISS
GO:0042472inner ear morphogenesisISS
GO:0042476odontogenesisISS
GO:0043410positive regulation of MAPK cascadeIMP
GO:0045087innate immune responseTAS
GO:0045165cell fate commitmentISS
GO:0045667regulation of osteoblast differentiationTAS
GO:0045787positive regulation of cell cycleISS
GO:0045839negative regulation of mitosisIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS
GO:0046777protein autophosphorylationIDA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048286lung alveolus developmentISS
GO:0048333mesodermal cell differentiationIEA
GO:0048489synaptic vesicle transportIEA
GO:0048557embryonic digestive tract morphogenesisISS
GO:0048562embryonic organ morphogenesisISS
GO:0048565digestive tract developmentISS
GO:0048568embryonic organ developmentISS
GO:0048608reproductive structure developmentISS
GO:0048661positive regulation of smooth muscle cell proliferationIEA
GO:0048701embryonic cranial skeleton morphogenesisIMP
GO:0048705skeletal system morphogenesisTAS
GO:0048730epidermis morphogenesisISS
GO:0048755branching morphogenesis of a nerveISS
GO:0048762mesenchymal cell differentiationISS
GO:0050679positive regulation of epithelial cell proliferationISS
GO:0050680negative regulation of epithelial cell proliferationIEA
GO:0051150regulation of smooth muscle cell differentiationISS
GO:0051781positive regulation of cell divisionISS
GO:0055010ventricular cardiac muscle tissue morphogenesisISS
GO:0060045positive regulation of cardiac muscle cell proliferationISS
GO:0060174limb bud formationISS
GO:0060348bone developmentISS
GO:0060349bone morphogenesisISS
GO:0060365coronal suture morphogenesisIEA
GO:0060442branching involved in prostate gland morphogenesisISS
GO:0060445branching involved in salivary gland morphogenesisISS
GO:0060449bud elongation involved in lung branchingISS
GO:0060463lung lobe morphogenesisISS
GO:0060484lung-associated mesenchyme developmentISS
GO:0060501positive regulation of epithelial cell proliferation involved in lung morphogenesisISS
GO:0060512prostate gland morphogenesisISS
GO:0060523prostate epithelial cord elongationISS
GO:0060527prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisISS
GO:0060529squamous basal epithelial stem cell differentiation involved in prostate gland acinus developmentISS
GO:0060595fibroblast growth factor receptor signaling pathway involved in mammary gland specificationISS
GO:0060601lateral sprouting from an epitheliumISS
GO:0060615mammary gland bud formationISS
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesisISS
GO:0060667branch elongation involved in salivary gland morphogenesisISS
GO:0060670branching involved in labyrinthine layer morphogenesisISS
GO:0060687regulation of branching involved in prostate gland morphogenesisISS
GO:0060688regulation of morphogenesis of a branching structureISS
GO:0060915mesenchymal cell differentiation involved in lung developmentISS
GO:0060916mesenchymal cell proliferation involved in lung developmentISS
GO:0061031endodermal digestive tract morphogenesisIEA
GO:0070307lens fiber cell developmentIEA
GO:0070372regulation of ERK1 and ERK2 cascadeISS
GO:0070374positive regulation of ERK1 and ERK2 cascadeISS
GO:0090263positive regulation of canonical Wnt signaling pathwayISS
Component
IDNameEvidence
GO:0005576extracellular regionIEA
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005794Golgi apparatusIEA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIDA
GO:0005938cell cortexIDA
GO:0009986cell surfaceIDA
GO:0016020membraneNAS
GO:0016021integral component of membraneNAS
GO:0016023cytoplasmic membrane-bounded vesicleIEA
GO:0031012extracellular matrixIDA
GO:0043231intracellular membrane-bounded organelleIDA
GO:0060076excitatory synapseISS
Function
IDNameEvidence
GO:0004713protein tyrosine kinase activityNAS
GO:0005007fibroblast growth factor-activated receptor activityIDA
GO:0005007fibroblast growth factor-activated receptor activityIGI
GO:0005007fibroblast growth factor-activated receptor activityNAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0008201heparin bindingIEA
GO:0017134fibroblast growth factor bindingIDA
GO:0017134fibroblast growth factor bindingIPI
GO:0042803protein homodimerization activityIPI
GeneCards FGFR2
UniProt P21802, D2CGD1, D3DRD5
Vega OTTHUMG00000019175
MIM 176943
Ensembl ENSG00000066468
HGNC 3689
HPRD 01492

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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