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FGFR4 fibroblast growth factor receptor 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002011 Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_022963 Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_213647 Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15

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Related Services

Gene Symbol FGFR4
Entrez Gene ID 2264
Full Name fibroblast growth factor receptor 4
Synonyms CD334, JTK2, MGC20292, TKF
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.1-qter

Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008].
Disorder

MIM: 134935

{Cancer progression/metastasis} (3)

mRNA Protein Product Sequence Price Select
NM_002011, 47524172 NP_002002, 47524173 fibroblast growth factor receptor 4 isoform 1 precursor ORF Sequence $660.00
NM_022963, 47524176 NP_075252, 47524177 fibroblast growth factor receptor 4 isoform 2 precursor ORF Sequence $700.00
NM_213647, 47524174 NP_998812, 47524175 fibroblast growth factor receptor 4 isoform 1 precursor ORF Sequence $660.00
KEGG
hsa04810Regulation of actin cytoskeleton
hsa04151PI3K-Akt signaling pathway
hsa04010MAPK signaling pathway
hsa04144Endocytosis
Pathway Interaction Database
fgf_pathwayFGF signaling pathway
WikiPathways
WP51Regulation of Actin Cytoskeleton
Reactome
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_115961PI3K events in ERBB4 signaling
REACT_115755Signaling by ERBB2
REACT_9452FGFR4 ligand binding and activation
REACT_75774Adaptive Immune System
REACT_111040Signaling by SCF-KIT
REACT_6900Immune System
REACT_111046betaKlotho-mediated ligand binding
REACT_115596Signaling by ERBB4
REACT_21270PI-3K cascade
REACT_120736Signaling by FGFR in disease
REACT_1195Insulin receptor signalling cascade
REACT_11061Signalling by NGF
REACT_9417Signaling by EGFR
REACT_9396FGFR ligand binding and activation
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_121286Signaling by FGFR4 mutants
REACT_12464PI3K/AKT activation
REACT_121398Signaling by FGFR mutants
REACT_498Signaling by Insulin receptor
REACT_115871Signaling by EGFR in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_6802Innate Immune System
REACT_762IRS-related events
REACT_332IRS-mediated signalling
REACT_21374SHC-mediated cascade
REACT_111102Signal Transduction
REACT_147814DAP12 signaling
REACT_21247FRS2-mediated cascade
REACT_17025Downstream signal transduction
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_976PI3K Cascade
REACT_16888Signaling by PDGF
REACT_116008PI3K events in ERBB2 signaling
REACT_12578GAB1 signalosome
REACT_111184Negative regulation of FGFR signaling
REACT_21272Downstream signaling of activated FGFR
REACT_9470Signaling by FGFR
REACT_21310Phospholipase C-mediated cascade
REACT_116125Disease
REACT_111247Klotho-mediated ligand binding
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_75829PIP3 activates AKT signaling
Homo sapiens (human)FGFR4NP_002002.3
Pan troglodytes (chimpanzee)FGFR4XP_518127.4
Macaca mulatta (Rhesus monkey)FGFR4XP_001087243.1
Canis lupus familiaris (dog)FGFR4XP_546211.3
Bos taurus (cattle)FGFR4NP_001179513.1
Mus musculus (house mouse)Fgfr4NP_032037.2
Rattus norvegicus (Norway rat)Fgfr4NP_001103374.1
Gallus gallus (chicken)FGFR4XP_003642120.1
Danio rerio (zebrafish)fgfr4NP_571505.1
GeneCards FGFR4
PDB 1QCT
UniProt P22455, Q96KE5, G3JVM2
MIM 134935
Ensembl ENSG00000160867
HGNC 3691
HPRD 00625

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
fibroblast growth factor receptor 4
Names
fibroblast growth factor receptor 4
FGFR-4
tyrosylprotein kinase
protein-tyrosine kinase
hydroxyaryl-protein kinase
tyrosine kinase related to fibroblast growth factor receptor
NP_002002.3
NP_075252.2
NP_998812.1

Interactant



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