• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


FGFR4 fibroblast growth factor receptor 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001291980 Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_002011 Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_022963 Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_213647 Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
XM_005265837 PREDICTED: Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005265838 PREDICTED: Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20

*Business Day

Related Services

Gene Symbol FGFR4
Entrez Gene ID 2264
Full Name fibroblast growth factor receptor 4
Synonyms CD334, JTK2, TKF
General protein information
Preferred Names
fibroblast growth factor receptor 4
Names
fibroblast growth factor receptor 4
FGFR-4
tyrosylprotein kinase
protein-tyrosine kinase
hydroxyaryl-protein kinase
tyrosine kinase related to fibroblast growth factor receptor
NP_002002.3
NP_075252.2
NP_998812.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.2

Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008].
Disorder

MIM: 134935

{Cancer progression/metastasis} (3)

mRNA Protein Product Sequence Price Select
NM_001291980, 634743313 NP_001278909, 634743314 fibroblast growth factor receptor 4 isoform 3 precursor ORF Sequence $700.00
NM_002011, 634743315 NP_002002, 47524173 fibroblast growth factor receptor 4 isoform 1 precursor ORF Sequence $660.00
NM_022963, 634743317 NP_075252, 47524177 fibroblast growth factor receptor 4 isoform 2 precursor ORF Sequence $700.00
NM_213647, 634743316 NP_998812, 47524175 fibroblast growth factor receptor 4 isoform 1 precursor ORF Sequence $660.00
XM_005265837, 578811035 XP_005265894, 530380897 fibroblast growth factor receptor 4 isoform X1 ORF Sequence $750.00
XM_005265838, 578811036 XP_005265895, 530380899 fibroblast growth factor receptor 4 isoform X2 ORF Sequence $750.00
KEGG
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04144Endocytosis
hsa04151PI3K-Akt signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WikiPathways
WP51Regulation of Actin Cytoskeleton
Pathway Interaction Database
fgf_pathwayFGF signaling pathway
Reactome
REACT_9470Signaling by FGFR
REACT_9452FGFR4 ligand binding and activation
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_9396FGFR ligand binding and activation
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_976PI3K Cascade
REACT_762IRS-related events
REACT_11061Signalling by NGF
REACT_1195Insulin receptor signalling cascade
REACT_12464PI3K/AKT activation
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21272Downstream signaling of activated FGFR
REACT_21310Phospholipase C-mediated cascade
REACT_21270PI-3K cascade
REACT_21247FRS2-mediated cascade
REACT_21374SHC-mediated cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111102Signal Transduction
REACT_111046betaKlotho-mediated ligand binding
REACT_111247Klotho-mediated ligand binding
REACT_111184Negative regulation of FGFR signaling
REACT_111040Signaling by SCF-KIT
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115596Signaling by ERBB4
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_121286Signaling by FGFR4 mutants
REACT_121398Signaling by FGFR mutants
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
Homo sapiens (human)FGFR4NP_002002.3
Pan troglodytes (chimpanzee)FGFR4XP_518127.4
Macaca mulatta (Rhesus monkey)FGFR4XP_001087243.1
Canis lupus familiaris (dog)FGFR4XP_005619229.1
Bos taurus (cattle)FGFR4NP_001179513.1
Mus musculus (house mouse)Fgfr4NP_032037.2
Rattus norvegicus (Norway rat)Fgfr4NP_001103374.1
Gallus gallus (chicken)FGFR4XP_003642120.2
Danio rerio (zebrafish)fgfr4NP_571505.1
Xenopus (Silurana) tropicalis (western clawed frog)fgfr4NP_001016323.1
Process
IDNameEvidence
GO:0001759organ inductionIEA
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0008284positive regulation of cell proliferationIDA
GO:0008284positive regulation of cell proliferationIGI
GO:0008286insulin receptor signaling pathwayTAS
GO:0008543fibroblast growth factor receptor signaling pathwayIDA
GO:0008543fibroblast growth factor receptor signaling pathwayIGI
GO:0008543fibroblast growth factor receptor signaling pathwayIPI
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0010715regulation of extracellular matrix disassemblyIMP
GO:0016477cell migrationIMP
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0019216regulation of lipid metabolic processISS
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042593glucose homeostasisISS
GO:0045087innate immune responseTAS
GO:0045862positive regulation of proteolysisIMP
GO:0046777protein autophosphorylationIDA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048554positive regulation of metalloenzyme activityIMP
GO:0055062phosphate ion homeostasisISS
GO:0061144alveolar secondary septum developmentIEA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMP
GO:0070857regulation of bile acid biosynthetic processIMP
GO:2000188regulation of cholesterol homeostasisISS
GO:2000573positive regulation of DNA biosynthetic processIMP
Component
IDNameEvidence
GO:0005576extracellular regionIEA
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005768endosomeIEA
GO:0005783endoplasmic reticulumIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIDA
GO:0005911cell-cell junctionIDA
Function
IDNameEvidence
GO:0004713protein tyrosine kinase activityTAS
GO:0005007fibroblast growth factor-activated receptor activityIDA
GO:0005007fibroblast growth factor-activated receptor activityIGI
GO:0005524ATP bindingIEA
GO:0008201heparin bindingIDA
GO:0017134fibroblast growth factor bindingIDA
GO:0017134fibroblast growth factor bindingIPI
GeneCards FGFR4
UniProt P22455
Vega OTTHUMG00000151523
MIM 134935
Ensembl ENSG00000160867
HGNC 3691
HPRD 00625

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FGFR4 gene?

The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.

The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.