• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


FGG fibrinogen gamma chain [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000509 Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-A, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_021870 Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-B, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol FGG
Entrez Gene ID 2266
Full Name fibrinogen gamma chain
Synonyms
General protein information
Preferred Names
fibrinogen gamma chain
Names
fibrinogen gamma chain
fibrinogen, gamma polypeptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q28

Summary The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Disorder

MIM: 134850

Dysfibrinogenemia, gamma type (3); Hypofibrinogenemia, gamma

mRNA Protein Product Sequence Price Select
NM_000509, 70906436 NP_000500, 70906437 fibrinogen gamma chain isoform gamma-A precursor ORF Sequence $360.00
NM_021870, 70906438 NP_068656, 70906439 fibrinogen gamma chain isoform gamma-B precursor ORF Sequence $550.00
KEGG
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
hsa04611Platelet activation
WikiPathways
WP272Blood Clotting Cascade
Pathway Interaction Database
il6_7pathwayIL6-mediated signaling events
reg_gr_pathwayGlucocorticoid receptor regulatory network
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Integrins
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_278Platelet Aggregation (Plug Formation)
REACT_1439Common Pathway
REACT_13552Integrin cell surface interactions
REACT_15523Integrin alphaIIb beta3 signaling
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_111102Signal Transduction
REACT_118779Extracellular matrix organization
Homo sapiens (human)FGGNP_068656.2
Pan troglodytes (chimpanzee)FGGXP_001138780.1
Macaca mulatta (Rhesus monkey)FGGXP_001089651.1
Canis lupus familiaris (dog)FGGXP_005629425.1
Bos taurus (cattle)FGGNP_776336.1
Mus musculus (house mouse)FggNP_598623.1
Rattus norvegicus (Norway rat)FggNP_036691.2
Gallus gallus (chicken)FGGNP_990320.1
Danio rerio (zebrafish)fggNP_998219.1
Xenopus (Silurana) tropicalis (western clawed frog)fggXP_002933524.1
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0007160cell-matrix adhesionIDA
GO:0007165signal transductionIEA
GO:0007596blood coagulationTAS
GO:0030168platelet activationTAS
GO:0030198extracellular matrix organizationTAS
GO:0034116positive regulation of heterotypic cell-cell adhesionIDA
GO:0043623cellular protein complex assemblyIDA
GO:0045907positive regulation of vasoconstrictionIDA
GO:0045921positive regulation of exocytosisIDA
GO:0050714positive regulation of protein secretionIDA
GO:0051258protein polymerizationIMP
GO:0051592response to calcium ionIDA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDA
GO:0070527platelet aggregationIDA
GO:0090277positive regulation of peptide hormone secretionIDA
GO:1900026positive regulation of substrate adhesion-dependent cell spreadingNAS
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIDA
GO:2000352negative regulation of endothelial cell apoptotic processIDA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005577fibrinogen complexIDA
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneTAS
GO:0005938cell cortexIEA
GO:0009897external side of plasma membraneIDA
GO:0009986cell surfaceIDA
GO:0031091platelet alpha granuleIDA
GO:0031093platelet alpha granule lumenTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0005102receptor bindingIPI
GO:0005198structural molecule activityIDA
GO:0030674protein binding, bridgingIEA
GO:0046872metal ion bindingIEA
GO:0050839cell adhesion molecule bindingIPI
GeneCards FGG
UniProt P02679
Vega OTTHUMG00000150329
MIM 134850
Ensembl ENSG00000171557
HGNC 3694
HPRD 00621

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FGG gene?

The FGG gene provides instructions for making the fibrinogen gamma (γ) chain, one piece (subunit) of the fibrinogen protein. This protein is important for blood clot formation (coagulation), which is needed to stop excessive bleeding after injury. To form fibrinogen, the γ chain attaches to the fibrinogen A alpha (Aα) and fibrinogen B beta (Bβ) chains, each produced from different genes. Two sets of this three-protein complex combine to form functional fibrinogen.

For coagulation to occur, another protein called thrombin removes a piece from the Aα and the Bβ subunits of the functional fibrinogen protein (the pieces are called the A and B fibrinopeptides). This process converts fibrinogen to fibrin, the main protein in blood clots. Fibrin proteins attach to each other, forming a stable network that makes up the blood clot.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.