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FGG fibrinogen gamma chain [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_000509 Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-A, mRNA. Full Length $482.85
ORF Sequence $381.06
NM_021870 Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-B, mRNA. Full Length $511.27
ORF Sequence $394.98


Gene Symbol FGG
Entrez Gene ID 2266
Full Name fibrinogen gamma chain
Synonyms
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q28
Summary The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq].
Disorder

MIM: 134850

Dysfibrinogenemia, gamma type (3); Hypofibrinogenemia, gamma
mRNA NM_000509, 70906436
Protein NP_000500, 70906437
Product fibrinogen gamma chain isoform gamma-A precursor
RefSeq Status REVIEWED
mRNA NM_021870, 70906438
Protein NP_068656, 70906439
Product fibrinogen gamma chain isoform gamma-B precursor
RefSeq Status REVIEWED
KEGG
hsa05150Staphylococcus aureus infection
hsa04610Complement and coagulation cascades
WikiPathways
WP272Blood Clotting Cascade
Pathway Interaction Database
il6_7pathwayIL6-mediated signaling events
reg_gr_pathwayGlucocorticoid receptor regulatory network
Reactome
REACT_278Platelet Aggregation (Plug Formation)
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Intergrins
REACT_798Platelet Activation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_318Platelet degranulation
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_604Hemostasis
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_20Formation of Platelet plug
REACT_15523Integrin alphaIIb beta3 signaling
REACT_13552Integrin cell surface interactions
REACT_1439Common Pathway
Homo sapiens (human)FGGNP_068656.2
Pan troglodytes (chimpanzee)FGGXP_517497.2
Canis lupus familiaris (dog)FGGXP_853752.1
Bos taurus (cattle)FGGNP_776336.1
Mus musculus (house mouse)FggNP_598623.1
Rattus norvegicus (Norway rat)FggNP_036691.2
Gallus gallus (chicken)FGGNP_990320.1
Danio rerio (zebrafish)fggNP_998219.1
Process
IDNameEvidence
GO:0002576platelet degranulationTAS
GO:0007165signal transductionIEA
GO:0007596blood coagulationTAS
GO:0030168platelet activationTAS
GO:0051258protein polymerizationIEA
GO:0051592response to calcium ionIDA
Component
IDNameEvidence
GO:0005576extracellular regionEXP
GO:0005576extracellular regionTAS
GO:0005577fibrinogen complexIEA
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneEXP
GO:0009897external side of plasma membraneIDA
GO:0031091platelet alpha granuleIDA
GO:0031093platelet alpha granule lumenTAS
Function
IDNameEvidence
GO:0005102receptor bindingIEA
GO:0030674protein binding, bridgingIEA
GO:0043499eukaryotic cell surface bindingIDA

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