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FGG fibrinogen gamma chain [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000509 Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-A, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_021870 Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-B, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol FGG
Entrez Gene ID 2266
Full Name fibrinogen gamma chain
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

MIM: 134850

Dysfibrinogenemia, gamma type (3); Hypofibrinogenemia, gamma

mRNA Protein Product Sequence Price Select
NM_000509, 70906436 NP_000500, 70906437 fibrinogen gamma chain isoform gamma-A precursor ORF Sequence $360.00
NM_021870, 70906438 NP_068656, 70906439 fibrinogen gamma chain isoform gamma-B precursor ORF Sequence $550.00
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
WP272Blood Clotting Cascade
Pathway Interaction Database
il6_7pathwayIL6-mediated signaling events
reg_gr_pathwayGlucocorticoid receptor regulatory network
REACT_13552Integrin cell surface interactions
REACT_278Platelet Aggregation (Plug Formation)
REACT_798Platelet activation, signaling and aggregation
REACT_111102Signal Transduction
REACT_1439Common Pathway
REACT_318Platelet degranulation
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Intergrins
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_15523Integrin alphaIIb beta3 signaling
Homo sapiens (human)FGGNP_068656.2
Pan troglodytes (chimpanzee)FGGXP_001138780.1
Macaca mulatta (Rhesus monkey)FGGXP_001089651.1
Canis lupus familiaris (dog)FGGXP_532698.2
Bos taurus (cattle)FGGNP_776336.1
Mus musculus (house mouse)FggNP_598623.1
Rattus norvegicus (Norway rat)FggNP_036691.2
Gallus gallus (chicken)FGGNP_990320.1
Danio rerio (zebrafish)fggNP_998219.1

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
fibrinogen gamma chain
fibrinogen gamma chain
fibrinogen, gamma polypeptide


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