ALDOB aldolase B, fructose-bisphosphate [Homo sapiens (human)]

Gene Symbol	ALDOB
Entrez Gene ID	229
Full Name	aldolase B, fructose-bisphosphate
Synonyms	ALDB, ALDO2
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:9 Map Location:9q21.3-q22.2
Summary	Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq].
Disorder	MIM: 612724 Fructose intolerance, 229600 (3)

mRNA	NM_000035, 218505812
Protein	NP_000026, 40354205
Product	fructose-bisphosphate aldolase B
RefSeq Status	REVIEWED

KEGG

hsa00051	Fructose and mannose metabolism
hsa01100	Metabolic pathways
hsa00010	Glycolysis / Gluconeogenesis
hsa00030	Pentose phosphate pathway

Pathway Interaction Database

hnf3bpathway

FOXA2 and FOXA3 transcription factor networks

WikiPathways

WP534

Glycolysis and Gluconeogenesis

Reactome

REACT_474	Metabolism of carbohydrates
REACT_723	Glucose metabolism
REACT_1383	Glycolysis
REACT_1520	Gluconeogenesis
REACT_1571	Fructose catabolism

Homo sapiens (human)	ALDOB	NP_000026.2
Pan troglodytes (chimpanzee)	ALDOB	XP_001136159.1
Canis lupus familiaris (dog)	ALDOB	XP_867355.1
Bos taurus (cattle)	ALDOB	NP_001029657.1
Mus musculus (house mouse)	Aldob	NP_659152.1
Rattus norvegicus (Norway rat)	Aldob	NP_036628.1
Gallus gallus (chicken)	ALDOB	XP_424890.1
Danio rerio (zebrafish)	aldob	NP_919348.3

Process

ID	Name	Evidence
GO:0001889	liver development	IEA
GO:0005975	carbohydrate metabolic process	TAS
GO:0006000	fructose metabolic process	IMP
GO:0006001	fructose catabolic process	TAS
GO:0006006	glucose metabolic process	TAS
GO:0006094	gluconeogenesis	TAS
GO:0006096	glycolysis	IDA
GO:0006096	glycolysis	TAS
GO:0006116	NADH oxidation	IDA
GO:0009743	response to carbohydrate stimulus	IEA
GO:0009750	response to fructose stimulus	IEA
GO:0010043	response to zinc ion	IEA
GO:0014070	response to organic cyclic compound	IEA
GO:0030388	fructose 1,6-bisphosphate metabolic process	IDA
GO:0031668	cellular response to extracellular stimulus	IEA
GO:0032781	positive regulation of ATPase activity	IGI
GO:0032869	cellular response to insulin stimulus	IEA
GO:0042493	response to drug	IEA
GO:0042594	response to starvation	IEA
GO:0043200	response to amino acid stimulus	IEA
GO:0043434	response to peptide hormone stimulus	IEA
GO:0046688	response to copper ion	IEA
GO:0051384	response to glucocorticoid stimulus	IEA
GO:0051591	response to cAMP	IEA
GO:0051789	response to protein stimulus	IEA
GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	IGI
GO:0070741	response to interleukin-6	IEA

Component

ID	Name	Evidence
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	IEA
GO:0005764	lysosome	IEA
GO:0005792	microsome	IEA
GO:0005815	microtubule organizing center	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IEA
GO:0030867	rough endoplasmic reticulum membrane	IEA
GO:0030868	smooth endoplasmic reticulum membrane	IEA
GO:0034451	centriolar satellite	IDA
GO:0048471	perinuclear region of cytoplasm	IEA

Function

ID	Name	Evidence
GO:0004332	fructose-bisphosphate aldolase activity	IDA
GO:0004332	fructose-bisphosphate aldolase activity	TAS
GO:0005515	protein binding	IPI
GO:0008092	cytoskeletal protein binding	IDA
GO:0016829	lyase activity	IEA
GO:0031210	phosphatidylcholine binding	IEA
GO:0042802	identical protein binding	IPI
GO:0051117	ATPase binding	IDA
GO:0070061	fructose binding	IMP

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RefSeq Accession	Definition	Sequence	Price	Select
NM_000035	Homo sapiens aldolase B, fructose-bisphosphate (ALDOB), mRNA.	Full Length	$703.54
NM_000035		ORF Sequence	$317.55