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ALDOB aldolase B, fructose-bisphosphate [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18947 NM_000035 Homo sapiens aldolase B, fructose-bisphosphate (ALDOB), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18947C NM_000035 Homo sapiens aldolase B, fructose-bisphosphate (ALDOB), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol ALDOB
Entrez Gene ID 229
Full Name aldolase B, fructose-bisphosphate
Synonyms ALDB, ALDO2
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q21.3-q22.2

Summary Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008].
Disorder

MIM: 612724

Fructose intolerance, 229600 (3)

mRNA Protein Product Sequence Price Select
NM_000035, 218505812 NP_000026, 40354205 fructose-bisphosphate aldolase B ORF Sequence $400.00
KEGG
hsa00051Fructose and mannose metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00030Pentose phosphate pathway
hsa_M00003Gluconeogenesis, oxaloacetate => fructose-6P
hsa_M00001Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa01230Biosynthesis of amino acids
hsa01200Carbon metabolism
WikiPathways
WP534Glycolysis and Gluconeogenesis
WP690Polyol pathway
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
BIOCYC
META_ANAEROFRUCAT-PWYhomolactic fermentation
HUMAN_GLUCONEO-PWYgluconeogenesis I
HUMAN_GLYCOLYSISglycolysis I
HUMAN_PWY66-373sucrose degradation V (mammalian)
META_PWY66-373sucrose degradation V (sucrose alpha-glucosidase)
META_PWY66-400glycolysis VI (metazoan)
META_PWY66-399gluconeogenesis III
Reactome
REACT_1383Glycolysis
REACT_1571Fructose catabolism
REACT_474Metabolism of carbohydrates
REACT_723Glucose metabolism
REACT_1520Gluconeogenesis
REACT_111217Metabolism
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)ALDOBNP_000026.2
Pan troglodytes (chimpanzee)ALDOBXP_001136159.1
Macaca mulatta (Rhesus monkey)ALDOBXP_001111095.1
Canis lupus familiaris (dog)ALDOBXP_867333.3
Bos taurus (cattle)ALDOBNP_001029657.1
Mus musculus (house mouse)AldobNP_659152.1
Rattus norvegicus (Norway rat)AldobNP_036628.2
Gallus gallus (chicken)ALDOBNP_001007978.1
Danio rerio (zebrafish)aldobNP_919348.3
Xenopus (Silurana) tropicalis (western clawed frog)aldobNP_989131.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0006000fructose metabolic processIMP
GO:0006001fructose catabolic processTAS
GO:0006006glucose metabolic processTAS
GO:0006094gluconeogenesisTAS
GO:0006096glycolytic processIDA
GO:0006096glycolytic processIEA
GO:0006096glycolytic processTAS
GO:0006116NADH oxidationIDA
GO:0030388fructose 1,6-bisphosphate metabolic processIDA
GO:0032781positive regulation of ATPase activityIGI
GO:0044281small molecule metabolic processTAS
GO:0070072vacuolar proton-transporting V-type ATPase complex assemblyIGI
Component
IDNameEvidence
GO:0005815microtubule organizing centerIDA
GO:0005829cytosolTAS
GO:0034451centriolar satelliteIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004332fructose-bisphosphate aldolase activityEXP
GO:0004332fructose-bisphosphate aldolase activityIDA
GO:0005515protein bindingIPI
GO:0008092cytoskeletal protein bindingIDA
GO:0042802identical protein bindingIPI
GO:0051117ATPase bindingIDA
GO:0070061fructose bindingIMP
GeneCards ALDOB
PDB 1XDL, 1XDM, 1QO5
UniProt P05062
Vega OTTHUMG00000020378
MIM 612724
Ensembl ENSG00000136872
HGNC 417
HPRD 01972

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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