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ALDOB aldolase B, fructose-bisphosphate [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000035 Homo sapiens aldolase B, fructose-bisphosphate (ALDOB), mRNA. ORF Sequence $317.55
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Gene Symbol ALDOB
Entrez Gene ID 229
Full Name aldolase B, fructose-bisphosphate
Synonyms ALDB, ALDO2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q21.3-q22.2

Summary Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008].
Disorder

MIM: 612724

Fructose intolerance, 229600 (3)

mRNA Protein Product Sequence Price Select
NM_000035, 218505812 NP_000026, 40354205 fructose-bisphosphate aldolase B Full Length $703.54
ORF Sequence $317.55
KEGG
hsa00030Pentose phosphate pathway
hsa_M00003Gluconeogenesis, oxaloacetate => fructose-6P
hsa_M00001Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa00051Fructose and mannose metabolism
hsa00010Glycolysis / Gluconeogenesis
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
WikiPathways
WP690Polyol pathway
WP534Glycolysis and Gluconeogenesis
BIOCYC
META_PWY66-373sucrose degradation V (mammalian)
HUMAN_PWY66-373sucrose degradation V (mammalian)
HUMAN_GLYCOLYSISglycolysis I
HUMAN_GLUCONEO-PWYgluconeogenesis I
Reactome
REACT_1571Fructose catabolism
REACT_1520Gluconeogenesis
REACT_474Metabolism of carbohydrates
REACT_111217Metabolism
REACT_723Glucose metabolism
REACT_1383Glycolysis
Homo sapiens (human)ALDOBNP_000026.2
Pan troglodytes (chimpanzee)ALDOBXP_001136159.1
Macaca mulatta (Rhesus monkey)ALDOBXP_001111095.1
Canis lupus familiaris (dog)ALDOBXP_867333.3
Bos taurus (cattle)ALDOBNP_001029657.1
Mus musculus (house mouse)AldobNP_659152.1
Rattus norvegicus (Norway rat)AldobNP_036628.2
Gallus gallus (chicken)ALDOBNP_001007978.1
Danio rerio (zebrafish)aldobNP_919348.3
GeneCards ALDOB
PDB 1XDL, 1XDM, 1QO5
UniProt P05062
MIM 612724
Ensembl ENSG00000136872
HGNC 417
HPRD 01972

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant

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