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FOXG1 forkhead box G1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005249 Homo sapiens forkhead box G1 (FOXG1), mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol FOXG1
Entrez Gene ID 2290
Full Name forkhead box G1
Synonyms BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF-2, HBF-3, HBF-G2, HBF2, HFK1, HFK2, HFK3, KHL2, QIN
General protein information
Preferred Names
forkhead box protein G1
Names
forkhead box protein G1
oncogene QIN
brain factor 1
brain factor 2
forkhead-like 1
forkhead-like 2
forkhead-like 3
forkhead-like 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q13

Summary This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012].
Disorder

MIM: 164874

Rett syndrome, congenital variant, 613454 (3)

mRNA Protein Product Sequence Price Select
NM_005249, 375151583 NP_005240, 32307177 forkhead box protein G1 ORF Sequence $550.00
KEGG
hsa04068FoxO signaling pathway
WikiPathways
WP366TGF-beta Receptor Signaling Pathway
Pathway Interaction Database
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
Homo sapiens (human)FOXG1NP_005240.3
Pan troglodytes (chimpanzee)FOXG1XP_003952518.1
Macaca mulatta (Rhesus monkey)LOC716287XP_001106922.2
Bos taurus (cattle)FOXG1XP_002707820.2
Mus musculus (house mouse)Foxg1NP_032267.1
Rattus norvegicus (Norway rat)Foxg1NP_036692.1
Danio rerio (zebrafish)foxg1aNP_571142.1
Xenopus (Silurana) tropicalis (western clawed frog)foxg1NP_001116933.1
Process
IDNameEvidence
GO:0002052positive regulation of neuroblast proliferationIEA
GO:0006351transcription, DNA-templatedIEA
GO:0007346regulation of mitotic cell cycleIEA
GO:0007420brain developmentTAS
GO:0007568agingIEA
GO:0009953dorsal/ventral pattern formationIEA
GO:0016199axon midline choice point recognitionIEA
GO:0021852pyramidal neuron migrationIEA
GO:0042472inner ear morphogenesisIEA
GO:0045665negative regulation of neuron differentiationIEA
GO:0045787positive regulation of cell cycleIEA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0048664neuron fate determinationIEA
Component
IDNameEvidence
GO:0005634nucleusIEA
Function
IDNameEvidence
GO:0003677DNA bindingTAS
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0005515protein bindingIPI
GO:0043565sequence-specific DNA bindingIEA
GeneCards FOXG1
UniProt P55316
Vega OTTHUMG00000140187
MIM 164874
Ensembl ENSG00000176165
HGNC 3811
HPRD 01283

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FOXG1 gene?

The FOXG1 gene provides instructions for making a protein known as forkhead box G1. This protein is a transcription factor, which means it helps regulate the activity of other genes. Specifically, the forkhead box G1 protein acts as a transcriptional repressor, turning off (repressing) the activity of certain genes when they are not needed. Researchers believe that this protein plays an important role in brain development, particularly in a region of the embryonic brain known as the telencephalon. The telencephalon ultimately develops into several critical structures, including the the largest part of the brain (the cerebrum), which controls most voluntary activity, language, sensory perception, learning, and memory.

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