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FLI1 Fli-1 proto-oncogene, ETS transcription factor [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001167681 Homo sapiens Fli-1 proto-oncogene, ETS transcription factor (FLI1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001271010 Homo sapiens Fli-1 proto-oncogene, ETS transcription factor (FLI1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001271012 Homo sapiens Fli-1 proto-oncogene, ETS transcription factor (FLI1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_002017 Homo sapiens Fli-1 proto-oncogene, ETS transcription factor (FLI1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Gene Symbol FLI1
Entrez Gene ID 2313
Full Name Fli-1 proto-oncogene, ETS transcription factor
Synonyms EWSR2, SIC-1
General protein information
Preferred Names
Friend leukemia integration 1 transcription factor
Names
Friend leukemia integration 1 transcription factor
proto-oncogene Fli-1
transcription factor ERGB
Ewing sarcoma breakpoint region 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q24.1-q24.3

Summary This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Disorder

MIM: 193067

mRNA Protein Product Sequence Price Select
NM_001167681, 328550502 NP_001161153, 264681554 Friend leukemia integration 1 transcription factor isoform 2 ORF Sequence $360.00
NM_001271010, 401871075 NP_001257939, 401871076 Friend leukemia integration 1 transcription factor isoform 3 ORF Sequence $400.00
NM_001271012, 401871077 NP_001257941, 401871078 Friend leukemia integration 1 transcription factor isoform 4 ORF Sequence $300.00
NM_002017, 401871074 NP_002008, 7110593 Friend leukemia integration 1 transcription factor isoform 1 ORF Sequence $360.00
KEGG
hsa05202Transcriptional misregulation in cancer
Homo sapiens (human)FLI1NP_002008.2
Pan troglodytes (chimpanzee)FLI1XP_508856.3
Macaca mulatta (Rhesus monkey)FLI1XP_002799924.1
Canis lupus familiaris (dog)FLI1XP_546404.2
Bos taurus (cattle)FLI1NP_001039763.1
Mus musculus (house mouse)Fli1NP_032052.1
Rattus norvegicus (Norway rat)Fli1NP_001017381.1
Gallus gallus (chicken)FLI1NP_001026079.1
Danio rerio (zebrafish)fli1aNP_571423.1
Xenopus (Silurana) tropicalis (western clawed frog)fli1NP_001096189.1
Process
IDNameEvidence
GO:0006357regulation of transcription from RNA polymerase II promoterIBA
GO:0006366transcription from RNA polymerase II promoterIBA
GO:0007599hemostasisTAS
GO:0009887organ morphogenesisTAS
GO:0030154cell differentiationIBA
Component
IDNameEvidence
GO:0005634nucleusIBA
Function
IDNameEvidence
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activityIBA
GO:0003677DNA bindingTAS
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0043565sequence-specific DNA bindingIEA
GeneCards FLI1
UniProt Q01543
Vega OTTHUMG00000165792
MIM 193067
Ensembl ENSG00000151702
HGNC 3749
HPRD 01901

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FLI1 gene?

The FLI1 gene provides instructions for making the FLI protein, which controls the activity (transcription) of genes. Transcription is the first step in the process of producing proteins. The FLI protein is part of a group of related proteins, called the Ets family of transcription factors, that control transcription. The FLI protein attaches (binds) to certain regions of DNA and turns on (activates) the transcription of nearby genes. The proteins produced from these genes control many important cellular processes, such as cell growth and division (proliferation), maturation (differentiation), and survival. The FLI protein is found primarily in blood cells and is thought to regulate their development.

Interactant

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