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FLNC filamin C, gamma [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26582 NM_001458 Homo sapiens filamin C, gamma (FLNC), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 40 $4749.00
OHu26755 NM_001127487 Homo sapiens filamin C, gamma (FLNC), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 40 $4749.00
OHu41458 XM_006715910 PREDICTED: Homo sapiens filamin C, gamma (FLNC), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 35 $3749.00
OHu26582C NM_001458 Homo sapiens filamin C, gamma (FLNC), transcript variant 1, mRNA. Customized vector On-demand 40 $4749.00
OHu26755C NM_001127487 Homo sapiens filamin C, gamma (FLNC), transcript variant 2, mRNA. Customized vector On-demand 40 $4749.00
OHu41458C XM_006715910 PREDICTED: Homo sapiens filamin C, gamma (FLNC), transcript variant X1, mRNA. Customized vector On-demand 35 $3749.00

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Gene Symbol FLNC
Entrez Gene ID 2318
Full Name filamin C, gamma
Synonyms ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4
General protein information
Preferred Names
filamin-C
Names
filamin-C
FLN-C
filamin 2
filamin-2
ABP-280-like protein
ABP-L, gamma filamin
actin binding protein 280
actin-binding-like protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q32-q35

Summary This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 102565

Myopathy, myofibrillar, filamin C-related, 609524 (3)

mRNA Protein Product Sequence Price Select
NM_001127487, 188595686 NP_001120959, 188595687 filamin-C isoform b ORF Sequence $4500.00
NM_001458, 188595685 NP_001449, 116805322 filamin-C isoform a ORF Sequence $4500.00
XM_006715910, 578814065 XP_006715973, 578814066 filamin-C isoform X1 ORF Sequence $3500.00
KEGG
hsa04010MAPK signaling pathway
hsa04510Focal adhesion
hsa05132Salmonella infection
hsa05205Proteoglycans in cancer
Reactome
REACT_20649Cell-extracellular matrix interactions
REACT_20676Cell junction organization
REACT_111155Cell-Cell communication
Homo sapiens (human)FLNCNP_001449.3
Pan troglodytes (chimpanzee)FLNCXP_519364.3
Macaca mulatta (Rhesus monkey)LOC700223XP_002808411.1
Canis lupus familiaris (dog)FLNCXP_539385.1
Bos taurus (cattle)FLNCNP_001193919.1
Mus musculus (house mouse)FlncNP_001074654.1
Rattus norvegicus (Norway rat)FlncNP_001178791.1
Gallus gallus (chicken)FLNCNP_989904.1
Danio rerio (zebrafish)flncaXP_002666982.1
Xenopus (Silurana) tropicalis (western clawed frog)flncXP_002931884.2
Process
IDNameEvidence
GO:0034329cell junction assemblyTAS
GO:0048747muscle fiber developmentIEA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0005856cytoskeletonIEA
GO:0005886plasma membraneIDA
GO:0016528sarcoplasmIEA
GO:0030018Z discIEA
GO:0042383sarcolemmaIDA
GO:0043034costamereTAS
Function
IDNameEvidence
GO:0003779actin bindingIEA
GO:0005515protein bindingIPI
GO:0008092cytoskeletal protein bindingIPI
GO:0030506ankyrin bindingIPI
GeneCards FLNC
UniProt Q59H94, Q14315
Vega OTTHUMG00000023627
MIM 102565
Ensembl ENSG00000128591
HGNC 3756
HPRD 00018

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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