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FLT3 fms-related tyrosine kinase 3 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004119 Homo sapiens fms-related tyrosine kinase 3 (FLT3), mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15

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Gene Symbol FLT3
Entrez Gene ID 2322
Full Name fms-related tyrosine kinase 3
Synonyms CD135, FLK2, STK1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008].

MIM: 136351

Leukemia, acute myeloid, reduced survival in (3); Leukemia,

mRNA Protein Product Sequence Price Select
NM_004119, 121114303 NP_004110, 121114304 receptor-type tyrosine-protein kinase FLT3 ORF Sequence $660.00
hsa05200Pathways in cancer
hsa04640Hematopoietic cell lineage
hsa05221Acute myeloid leukemia
hsa04060Cytokine-cytokine receptor interaction
hsa05202Transcriptional misregulation in cancer
Homo sapiens (human)FLT3NP_004110.2
Pan troglodytes (chimpanzee)FLT3XP_509601.2
Macaca mulatta (Rhesus monkey)FLT3XP_001117913.1
Canis lupus familiaris (dog)FLT3NP_001018647.1
Bos taurus (cattle)FLT3XP_002691902.1
Mus musculus (house mouse)Flt3NP_034359.2
Rattus norvegicus (Norway rat)Flt3NP_001094292.1
Gallus gallus (chicken)LOC100858422XP_003640660.1
Danio rerio (zebrafish)LOC566708XP_001921760.1
GeneCards FLT3
PDB 3QS7, 3QS9, 1RJB
UniProt P36888
MIM 136351
Ensembl ENSG00000122025
HGNC 3765
HPRD 00635

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
receptor-type tyrosine-protein kinase FLT3
receptor-type tyrosine-protein kinase FLT3
CD135 antigen
FL cytokine receptor
fetal liver kinase 2
fms-like tyrosine kinase 3
stem cell tyrosine kinase 1
growth factor receptor tyrosine kinase type III


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