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FLT3 fms-related tyrosine kinase 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004119 Homo sapiens fms-related tyrosine kinase 3 (FLT3), mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15

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Gene Symbol FLT3
Entrez Gene ID 2322
Full Name fms-related tyrosine kinase 3
Synonyms CD135, FLK-2, FLK2, STK1
General protein information
Preferred Names
receptor-type tyrosine-protein kinase FLT3
Names
receptor-type tyrosine-protein kinase FLT3
STK-1
CD135 antigen
FL cytokine receptor
fetal liver kinase 2
fms-like tyrosine kinase 3
stem cell tyrosine kinase 1
growth factor receptor tyrosine kinase type III
NP_004110.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q12

Summary This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008].
Disorder

MIM: 136351

Leukemia, acute myeloid, reduced survival in (3); Leukemia,

mRNA Protein Product Sequence Price Select
NM_004119, 121114303 NP_004110, 121114304 receptor-type tyrosine-protein kinase FLT3 ORF Sequence $660.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04640Hematopoietic cell lineage
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
Homo sapiens (human)FLT3NP_004110.2
Pan troglodytes (chimpanzee)FLT3XP_509601.2
Macaca mulatta (Rhesus monkey)FLT3XP_001117913.1
Canis lupus familiaris (dog)FLT3NP_001018647.1
Bos taurus (cattle)FLT3XP_002691902.2
Mus musculus (house mouse)Flt3NP_034359.2
Rattus norvegicus (Norway rat)Flt3NP_001094292.1
Gallus gallus (chicken)FLT3XP_003640660.2
Danio rerio (zebrafish)flt3XP_001921760.2
Xenopus (Silurana) tropicalis (western clawed frog)flt3XP_004912442.1
Process
IDNameEvidence
GO:0001776leukocyte homeostasisISS
GO:0002318myeloid progenitor cell differentiationISS
GO:0002328pro-B cell differentiationISS
GO:0002572pro-T cell differentiationIEA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS
GO:0008284positive regulation of cell proliferationTAS
GO:0008285negative regulation of cell proliferationIEA
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingTAS
GO:0018108peptidyl-tyrosine phosphorylationTAS
GO:0019221cytokine-mediated signaling pathwayISS
GO:0030097hemopoiesisIDA
GO:0030183B cell differentiationISS
GO:0035726common myeloid progenitor cell proliferationISS
GO:0038084vascular endothelial growth factor signaling pathwayTAS
GO:0042531positive regulation of tyrosine phosphorylation of STAT proteinTAS
GO:0042981regulation of apoptotic processTAS
GO:0043406positive regulation of MAP kinase activityTAS
GO:0043410positive regulation of MAPK cascadeTAS
GO:0043552positive regulation of phosphatidylinositol 3-kinase activityTAS
GO:0045578negative regulation of B cell differentiationIEA
GO:0046651lymphocyte proliferationISS
GO:0046777protein autophosphorylationTAS
GO:0071345cellular response to cytokine stimulusISS
GO:0071345cellular response to cytokine stimulusTAS
GO:0097028dendritic cell differentiationISS
Component
IDNameEvidence
GO:0005788endoplasmic reticulum lumenIEA
GO:0005887integral component of plasma membraneTAS
GO:0009986cell surfaceIEA
Function
IDNameEvidence
GO:0004714transmembrane receptor protein tyrosine kinase activityTAS
GO:0004896cytokine receptor activityISS
GO:0005021vascular endothelial growth factor-activated receptor activityTAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0042803protein homodimerization activityTAS
GO:0043548phosphatidylinositol 3-kinase bindingIEA
GeneCards FLT3
UniProt P36888
Vega OTTHUMG00000016646
MIM 136351
Ensembl ENSG00000122025
HGNC 3765
HPRD 00635

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FLT3 gene?

The FLT3 gene provides instructions for making a protein called fms-like tyrosine kinase 3 (FLT3), which is part of a family of proteins called receptor tyrosine kinases (RTKs). Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction. The FLT3 protein is found in the outer membrane of certain cell types where a specific protein called FLT3 ligand, or FL, can attach (bind) to it. This binding turns on (activates) the FLT3 protein, which subsequently activates a series of proteins inside the cell that are part of multiple signaling pathways. The signaling pathways stimulated by the FLT3 protein control many important cellular processes such as the growth and division (proliferation) and survival of cells, particularly of early blood cells called hematopoietic progenitor cells.

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