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Sequence in raw or FASTA format:

Database:

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CRB1 crumbs family member 1, photoreceptor morphogenesis associated [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17475 NM_001193640 Homo sapiens crumbs family member 1, photoreceptor morphogenesis associated (CRB1), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu19399 NM_201253 Homo sapiens crumbs family member 1, photoreceptor morphogenesis associated (CRB1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 16 $1149.00
OHu22677 NM_001257965 Homo sapiens crumbs family member 1, photoreceptor morphogenesis associated (CRB1), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu22808 NM_001257966 Homo sapiens crumbs family member 1, photoreceptor morphogenesis associated (CRB1), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu34279 XM_006711249 PREDICTED: Homo sapiens crumbs homolog 1 (Drosophila) (CRB1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu34280 XM_006711250 PREDICTED: Homo sapiens crumbs homolog 1 (Drosophila) (CRB1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu17475C NM_001193640 Homo sapiens crumbs family member 1, photoreceptor morphogenesis associated (CRB1), transcript variant 2, mRNA. Customized vector On-demand 25 $1699.00
OHu19399C NM_201253 Homo sapiens crumbs family member 1, photoreceptor morphogenesis associated (CRB1), transcript variant 1, mRNA. Customized vector In-stock 16 $1149.00
OHu22677C NM_001257965 Homo sapiens crumbs family member 1, photoreceptor morphogenesis associated (CRB1), transcript variant 3, mRNA. Customized vector On-demand 25 $1699.00
OHu22808C NM_001257966 Homo sapiens crumbs family member 1, photoreceptor morphogenesis associated (CRB1), transcript variant 4, mRNA. Customized vector On-demand 12-14 $329.00
OHu34279C XM_006711249 PREDICTED: Homo sapiens crumbs homolog 1 (Drosophila) (CRB1), transcript variant X1, mRNA. Customized vector On-demand 25 $1699.00
OHu34280C XM_006711250 PREDICTED: Homo sapiens crumbs homolog 1 (Drosophila) (CRB1), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol CRB1
Entrez Gene ID 23418
Full Name crumbs family member 1, photoreceptor morphogenesis associated
Synonyms LCA8, RP12
General protein information
Preferred Names
protein crumbs homolog 1
Names
protein crumbs homolog 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q31-q32.1

Summary This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012].
Disorder

MIM: 604210

Retinitis pigmentosa-12, autosomal recessive, 600105 (3);

mRNA Protein Product Sequence Price Select
NM_001193640, 302370925 NP_001180569, 302370926 protein crumbs homolog 1 isoform 2 precursor ORF Sequence $1500.00
NM_001257965, 384081578 NP_001244894, 384081579 protein crumbs homolog 1 isoform 3 ORF Sequence $1500.00
NM_001257966, 384081580 NP_001244895, 384081581 protein crumbs homolog 1 isoform 4 precursor ORF Sequence $750.00
NM_201253, 302370924 NP_957705, 41327708 protein crumbs homolog 1 isoform 1 precursor ORF Sequence $999.00
XM_006711249, 578800758 XP_006711312, 578800759 protein crumbs homolog 1 isoform X1 ORF Sequence $1500.00
XM_006711250, 578800760 XP_006711313, 578800761 protein crumbs homolog 1 isoform X2 ORF Sequence $750.00
KEGG
hsa04390Hippo signaling pathway
Homo sapiens (human)CRB1NP_957705.1
Pan troglodytes (chimpanzee)CRB1XP_525009.2
Macaca mulatta (Rhesus monkey)CRB1XP_001110912.1
Canis lupus familiaris (dog)CRB1XP_005622350.1
Bos taurus (cattle)CRB1NP_001179411.1
Mus musculus (house mouse)Crb1NP_573502.2
Rattus norvegicus (Norway rat)Crb1NP_001100652.1
Gallus gallus (chicken)CRB1XP_003641718.2
Danio rerio (zebrafish)crb1NP_001038408.1
Xenopus (Silurana) tropicalis (western clawed frog)crb1XP_002932223.2
Process
IDNameEvidence
GO:0007009plasma membrane organizationIEA
GO:0007163establishment or maintenance of cell polarityTAS
GO:0007267cell-cell signalingTAS
GO:0042462eye photoreceptor cell developmentIEA
Component
IDNameEvidence
GO:0005576extracellular regionIEA
GO:0005902microvillusIEA
GO:0016021integral component of membraneIEA
GO:0016324apical plasma membraneIEA
Function
IDNameEvidence
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GeneCards CRB1
UniProt B7Z826, F5H0L2, P82279, A8K118
Vega OTTHUMG00000035663
MIM 604210
Ensembl ENSG00000134376
HGNC 2343
HPRD 05019

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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