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TARDBP TAR DNA binding protein [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19093 NM_007375 Homo sapiens TAR DNA binding protein (TARDBP), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu19093C NM_007375 Homo sapiens TAR DNA binding protein (TARDBP), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol TARDBP
Entrez Gene ID 23435
Full Name TAR DNA binding protein
Synonyms ALS10, TDP-43
General protein information
Preferred Names
TAR DNA-binding protein 43
Names
TAR DNA-binding protein 43
TAR DNA-binding protein-43
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.22

Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605078

Amyotrophic lateral sclerosis 10, with or without FTD, 612069 (3);

mRNA Protein Product Sequence Price Select
NM_007375, 42741653 NP_031401, 6678271 TAR DNA-binding protein 43 ORF Sequence $269.00
Homo sapiens (human)TARDBPNP_031401.1
Pan troglodytes (chimpanzee)TARDBPXP_514380.2
Macaca mulatta (Rhesus monkey)TARDBPXP_001102660.1
Canis lupus familiaris (dog)TARDBPXP_005618063.1
Bos taurus (cattle)TARDBPNP_001039950.2
Mus musculus (house mouse)TardbpNP_663531.1
Gallus gallus (chicken)TARDBPNP_001026049.1
Danio rerio (zebrafish)tardbpNP_958884.1
Xenopus (Silurana) tropicalis (western clawed frog)tardbpNP_989054.2
Process
IDNameEvidence
GO:0006355regulation of transcription, DNA-templatedIEA
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0006397mRNA processingIEA
GO:0008219cell deathIEA
GO:0008380RNA splicingIDA
GO:0043922negative regulation by host of viral transcriptionIDA
GO:00709353'-UTR-mediated mRNA stabilizationIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003690double-stranded DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0003723RNA bindingIDA
GO:0003730mRNA 3'-UTR bindingIDA
GO:0005515protein bindingIPI
GO:0042802identical protein bindingIPI
GO:0044822poly(A) RNA bindingIDA
GeneCards TARDBP
PDB 1WF0, 4IUF, 4BS2, 2CQG
UniProt Q9H256, Q13148
MIM 605078
HGNC 11571
HPRD 05466

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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