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TARDBP TAR DNA binding protein [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_007375 Homo sapiens TAR DNA binding protein (TARDBP), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Gene Symbol TARDBP
Entrez Gene ID 23435
Full Name TAR DNA binding protein
Synonyms ALS10, TDP-43
General protein information
Preferred Names
TAR DNA-binding protein 43
Names
TAR DNA-binding protein 43
TAR DNA-binding protein-43
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.22

Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605078

Amyotrophic lateral sclerosis 10, with or without FTD, 612069 (3);

mRNA Protein Product Sequence Price Select
NM_007375, 42741653 NP_031401, 6678271 TAR DNA-binding protein 43 ORF Sequence $269.00
Homo sapiens (human)TARDBPNP_031401.1
Pan troglodytes (chimpanzee)TARDBPXP_514380.2
Macaca mulatta (Rhesus monkey)TARDBPXP_001102660.1
Canis lupus familiaris (dog)TARDBPXP_005618063.1
Bos taurus (cattle)TARDBPNP_001039950.2
Mus musculus (house mouse)TardbpNP_663531.1
Gallus gallus (chicken)TARDBPNP_001026049.1
Danio rerio (zebrafish)tardbpNP_958884.1
Xenopus (Silurana) tropicalis (western clawed frog)tardbpNP_989054.2
Process
IDNameEvidence
GO:0006355regulation of transcription, DNA-templatedIEA
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0006397mRNA processingIEA
GO:0008219cell deathIEA
GO:0008380RNA splicingIDA
GO:0043922negative regulation by host of viral transcriptionIDA
GO:00709353'-UTR-mediated mRNA stabilizationIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003690double-stranded DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0003723RNA bindingIDA
GO:0003730mRNA 3'-UTR bindingIDA
GO:0005515protein bindingIPI
GO:0042802identical protein bindingIPI
GO:0044822poly(A) RNA bindingIDA
GeneCards TARDBP
PDB 1WF0, 4IUF, 4BS2, 2CQG
UniProt Q9H256, Q13148
MIM 605078
HGNC 11571
HPRD 05466

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TARDBP gene?

The TARDBP gene provides instructions for making a protein called transactive response DNA binding protein 43 kDa (TDP-43). This protein is found within the cell nucleus in most tissues and is involved in many of the steps of protein production. The TDP-43 protein attaches (binds) to DNA and regulates an activity called transcription, which is the first step in the production of proteins from genes. This protein can also bind to RNA, a chemical cousin of DNA, to ensure the RNA's stability. The TDP-43 gene is involved in processing molecules called messenger RNA (mRNA), which serve as genetic blueprints for making proteins. By cutting and rearranging mRNA molecules in different ways, the TDP-43 protein controls the production of different versions of certain proteins. This process is known as alternative splicing. The TDP-43 can influence various functions of a cell by regulating protein production.

The TARDBP gene is particularly active (expressed) during early development before birth when new tissues are forming. Many of the proteins whose production is influenced by the TDP-43 protein are involved in neuronal and organ development.

Interactant

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