Sequence in raw or FASTA format:
TARDBP TAR DNA binding protein [Homo sapiens (human)]
|Entrez Gene ID||23435|
|Full Name||TAR DNA binding protein|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008].|
Amyotrophic lateral sclerosis 10, with or without FTD, 612069 (3);
|Homo sapiens (human)||TARDBP||NP_031401.1|
|Pan troglodytes (chimpanzee)||TARDBP||XP_514380.2|
|Macaca mulatta (Rhesus monkey)||TARDBP||XP_001102660.1|
|Canis lupus familiaris (dog)||TARDBP||XP_005618063.1|
|Bos taurus (cattle)||TARDBP||NP_001039950.2|
|Mus musculus (house mouse)||Tardbp||NP_663531.1|
|Gallus gallus (chicken)||TARDBP||NP_001026049.1|
|Danio rerio (zebrafish)||tardbp||NP_958884.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||tardbp||NP_989054.2|
|GO:0006355||regulation of transcription, DNA-templated||IEA|
|GO:0006366||transcription from RNA polymerase II promoter||TAS|
|GO:0043922||negative regulation by host of viral transcription||IDA|
|GO:0070935||3'-UTR-mediated mRNA stabilization||IDA|
|GO:0003690||double-stranded DNA binding||IDA|
|GO:0003700||sequence-specific DNA binding transcription factor activity||TAS|
|GO:0003730||mRNA 3'-UTR binding||IDA|
|GO:0042802||identical protein binding||IPI|
|GO:0044822||poly(A) RNA binding||IDA|
What is the normal function of the TARDBP gene?
The TARDBP gene provides instructions for making a protein called transactive response DNA binding protein 43 kDa (TDP-43). This protein is found within the cell nucleus in most tissues and is involved in many of the steps of protein production. The TDP-43 protein attaches (binds) to DNA and regulates an activity called transcription, which is the first step in the production of proteins from genes. This protein can also bind to RNA, a chemical cousin of DNA, to ensure the RNA's stability. The TDP-43 gene is involved in processing molecules called messenger RNA (mRNA), which serve as genetic blueprints for making proteins. By cutting and rearranging mRNA molecules in different ways, the TDP-43 protein controls the production of different versions of certain proteins. This process is known as alternative splicing. The TDP-43 can influence various functions of a cell by regulating protein production.
The TARDBP gene is particularly active (expressed) during early development before birth when new tissues are forming. Many of the proteins whose production is influenced by the TDP-43 protein are involved in neuronal and organ development.
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