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CLCF1 cardiotrophin-like cytokine factor 1 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_013246 Homo sapiens cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 1, mRNA. Full Length $539.40
ORF Sequence $196.62
NM_001166212 Homo sapiens cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 2, mRNA. Full Length $515.91
ORF Sequence $187.92


Gene Symbol CLCF1
Entrez Gene ID 23529
Full Name cardiotrophin-like cytokine factor 1
Synonyms BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13.3
Summary This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Disorder

MIM: 607672

Cold-induced sweating syndrome 1, 610313 (3)
mRNA NM_013246, 50726992
Protein NP_037378, 7019351
Product cardiotrophin-like cytokine factor 1 isoform 1
RefSeq Status REVIEWED
mRNA NM_001166212, 261245021
Protein NP_001159684, 261245022
Product cardiotrophin-like cytokine factor 1 isoform 2
RefSeq Status REVIEWED
KEGG
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Homo sapiens (human)CLCF1NP_037378.1
Canis lupus familiaris (dog)CLCF1XP_540818.2
Mus musculus (house mouse)Clcf1NP_064336.1
Rattus norvegicus (Norway rat)Clcf1NP_997498.2
Process
IDNameEvidence
GO:0002639positive regulation of immunoglobulin productionISS
GO:0007166cell surface receptor linked signaling pathwayISS
GO:0007259JAK-STAT cascadeISS
GO:0008284positive regulation of cell proliferationIDA
GO:0019221cytokine-mediated signaling pathwayNAS
GO:0030183B cell differentiationISS
GO:0030890positive regulation of B cell proliferationISS
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIDA
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinTAS
GO:0043066negative regulation of apoptosisTAS
GO:0043524negative regulation of neuron apoptosisIDA
GO:0048295positive regulation of isotype switching to IgE isotypesISS
GO:0048711positive regulation of astrocyte differentiationISS
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005576extracellular regionNAS
GO:0005615extracellular spaceIEA
Function
IDNameEvidence
GO:0005102receptor bindingIPI
GO:0005125cytokine activityIDA
GO:0005125cytokine activityNAS
GO:0005127ciliary neurotrophic factor receptor bindingIDA
GO:0005127ciliary neurotrophic factor receptor bindingIDA
GO:0005515protein bindingIPI
GO:0008083growth factor activityTAS
GO:0046982protein heterodimerization activityIDA
GeneCards CLCF1
UniProt Q9UBD9, B4DNT4
MIM 607672
Ensembl ENSG00000175505
HGNC 17412
HPRD 09643

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