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CLCF1 cardiotrophin-like cytokine factor 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001166212 Homo sapiens cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_013246 Homo sapiens cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol CLCF1
Entrez Gene ID 23529
Full Name cardiotrophin-like cytokine factor 1
Synonyms BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].

MIM: 607672

Cold-induced sweating syndrome 1, 610313 (3)

mRNA Protein Product Sequence Price Select
NM_001166212, 261245021 NP_001159684, 261245022 cardiotrophin-like cytokine factor 1 isoform 2 precursor ORF Sequence $159.00
NM_013246, 50726992 NP_037378, 7019351 cardiotrophin-like cytokine factor 1 isoform 1 precursor ORF Sequence $159.00
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Homo sapiens (human)CLCF1NP_037378.1
Macaca mulatta (Rhesus monkey)CLCF1XP_001106809.1
Canis lupus familiaris (dog)CLCF1XP_540818.2
Bos taurus (cattle)CLCF1XP_002699410.1
Mus musculus (house mouse)Clcf1NP_064336.1
Rattus norvegicus (Norway rat)Clcf1NP_997498.2
Gallus gallus (chicken)LOC100858060XP_003643835.1
Danio rerio (zebrafish)LOC562247XP_690733.4
GeneCards CLCF1
UniProt Q9UBD9
MIM 607672
Ensembl ENSG00000175505
HGNC 17412
HPRD 09643

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cardiotrophin-like cytokine factor 1
cardiotrophin-like cytokine factor 1
novel neurotrophin-1
B-cell stimulating factor 3
B-cell stimulatory factor 3
B-cell-stimulating factor 3
CRLF1 associated cytokine-like factor 1
neurotrophin-1/B-cell stimulating factor-3


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