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CLCF1 cardiotrophin-like cytokine factor 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001166212 Homo sapiens cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_013246 Homo sapiens cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol CLCF1
Entrez Gene ID 23529
Full Name cardiotrophin-like cytokine factor 1
Synonyms BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6
General protein information
Preferred Names
cardiotrophin-like cytokine factor 1
cardiotrophin-like cytokine factor 1
novel neurotrophin-1
B-cell stimulating factor 3
B-cell stimulatory factor 3
B-cell-stimulating factor 3
CRLF1 associated cytokine-like factor 1
neurotrophin-1/B-cell stimulating factor-3
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].

MIM: 607672

Cold-induced sweating syndrome 1, 610313 (3)

mRNA Protein Product Sequence Price Select
NM_001166212, 261245021 NP_001159684, 261245022 cardiotrophin-like cytokine factor 1 isoform 2 precursor ORF Sequence $159.00
NM_013246, 50726992 NP_037378, 7019351 cardiotrophin-like cytokine factor 1 isoform 1 precursor ORF Sequence $159.00
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Homo sapiens (human)CLCF1NP_037378.1
Macaca mulatta (Rhesus monkey)CLCF1XP_001106809.1
Canis lupus familiaris (dog)CLCF1XP_540818.2
Bos taurus (cattle)CLCF1XP_002699410.1
Mus musculus (house mouse)Clcf1NP_064336.1
Rattus norvegicus (Norway rat)Clcf1NP_997498.2
Gallus gallus (chicken)CLCF1XP_003643835.2
Danio rerio (zebrafish)LOC562247XP_690733.5
Xenopus (Silurana) tropicalis (western clawed frog)clcf1NP_001016067.1
GO:0002639positive regulation of immunoglobulin productionISS
GO:0007166cell surface receptor signaling pathwayISS
GO:0007259JAK-STAT cascadeISS
GO:0008284positive regulation of cell proliferationIDA
GO:0019221cytokine-mediated signaling pathwayNAS
GO:0030183B cell differentiationISS
GO:0030890positive regulation of B cell proliferationISS
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIDA
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinTAS
GO:0043524negative regulation of neuron apoptotic processIDA
GO:0048295positive regulation of isotype switching to IgE isotypesISS
GO:0048711positive regulation of astrocyte differentiationISS
GO:0005576extracellular regionIDA
GO:0005576extracellular regionNAS
GO:0070062extracellular vesicular exosomeIDA
GO:0097058CRLF-CLCF1 complexIDA
GO:0097059CNTFR-CLCF1 complexIDA
GO:0005102receptor bindingIPI
GO:0005125cytokine activityIDA
GO:0005125cytokine activityNAS
GO:0005127ciliary neurotrophic factor receptor bindingIDA
GO:0005127ciliary neurotrophic factor receptor bindingIDA
GO:0005515protein bindingIPI
GO:0008083growth factor activityTAS
GO:0046982protein heterodimerization activityIDA
GeneCards CLCF1
UniProt Q9UBD9
Vega OTTHUMG00000167669
MIM 607672
Ensembl ENSG00000175505
HGNC 17412
HPRD 09643

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CLCF1 gene?

The CLCF1 gene provides instructions for making a protein called cardiotrophin-like cytokine factor 1 (CLCF1). This protein partners with a similar protein called cytokine receptor-like factor 1 (CRLF1), which is produced from the CRLF1 gene. Together, these two proteins form a unit known as the CRLF1/CLCF1 protein complex. This complex attaches (binds) to a receptor protein known as the ciliary neurotrophic factor receptor (CNTFR) on the surface of many types of cells. When the CRLF1/CLCF1 protein complex is bound to CNTFR, it triggers signaling inside the cell that affects cell development and function.

The CNTFR signaling pathway is primarily involved in the development and maintenance of the nervous system. It promotes the survival of nerve cells (neurons), particularly nerve cells that control muscle movement (motor neurons). The CNTFR pathway also plays a role in a part of the nervous system called the sympathetic nervous system, specifically in the regulation of sweating in response to temperature changes and other factors. This signaling pathway appears to be critical for the normal development and maturation of nerve cells that control the activity of sweat glands.

Studies suggest that the CNTFR signaling pathway also has functions outside the nervous system. It may be involved in the body's inflammatory response, which helps fight infection and facilitate tissue repair following an injury. This pathway may also be important for the development and maintenance of bone tissue. However, little is known about the role of CNTFR signaling in these processes.


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