• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


CLDN14 claudin 14 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001146077 Homo sapiens claudin 14 (CLDN14), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001146078 Homo sapiens claudin 14 (CLDN14), transcript variant gamma, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001146079 Homo sapiens claudin 14 (CLDN14), transcript variant 5, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_012130 Homo sapiens claudin 14 (CLDN14), transcript variant epsilon, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_144492 Homo sapiens claudin 14 (CLDN14), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

*Business Day

Related Services

Gene Symbol CLDN14
Entrez Gene ID 23562
Full Name claudin 14
Synonyms DFNB29
General protein information
Preferred Names
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010].

MIM: 605608

Deafness, autosomal recessive 29 (3)

mRNA Protein Product Sequence Price Select
NM_001146077, 225703137 NP_001139549, 225703138 claudin-14 ORF Sequence $159.00
NM_001146078, 393538652 NP_001139550, 225703140 claudin-14 ORF Sequence $159.00
NM_001146079, 225703141 NP_001139551, 225703142 claudin-14 ORF Sequence $159.00
NM_012130, 393538862 NP_036262, 6912314 claudin-14 ORF Sequence $159.00
NM_144492, 225703134 NP_652763, 21536294 claudin-14 ORF Sequence $159.00
hsa04530Tight junction
hsa04514Cell adhesion molecules (CAMs)
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
REACT_19331Cell-cell junction organization
REACT_19373Tight junction interactions
REACT_20676Cell junction organization
REACT_111155Cell-Cell communication
Homo sapiens (human)CLDN14NP_001139549.1
Pan troglodytes (chimpanzee)CLDN14XP_525469.1
Macaca mulatta (Rhesus monkey)CLDN14XP_002803185.1
Canis lupus familiaris (dog)CLDN14XP_005638958.1
Bos taurus (cattle)CLDN14XP_005202183.1
Mus musculus (house mouse)Cldn14NP_001159398.1
Rattus norvegicus (Norway rat)Cldn14NP_001013447.1
Gallus gallus (chicken)CLDN14XP_004934594.1
Danio rerio (zebrafish)cldn2NP_001004559.2
Xenopus (Silurana) tropicalis (western clawed frog)cldn14XP_004912176.1
GO:0006461protein complex assemblyTAS
GO:0016338calcium-independent cell-cell adhesionISS
GO:0034329cell junction assemblyTAS
GO:0045216cell-cell junction organizationTAS
GO:0070830tight junction assemblyTAS
GO:0005783endoplasmic reticulumIDA
GO:0005886plasma membraneIDA
GO:0005923tight junctionISS
GO:0016021integral component of membraneIEA
GO:0005198structural molecule activityIEA
GO:0042802identical protein bindingISS
GeneCards CLDN14
UniProt O95500
Vega OTTHUMG00000086638
MIM 605608
Ensembl ENSG00000159261
HGNC 2035
HPRD 05727

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CLDN14 gene?

The CLDN14 gene provides instructions for making a protein called claudin 14. This protein is a member of the claudin protein family, which provides building components for tight junctions. Tight junctions seal the space between cells, creating a barrier that restricts the passage of fluids and certain particles in and out of cells. For example, tight junctions prevent digestive enzymes in intestinal cells from leaking into the blood.

Claudin 14 is found in the liver, kidneys, and inner ear, but its exact function is unclear. In the inner ear, this protein probably plays a role in converting sound waves to nerve impulses, a critical process for normal hearing. This conversion process requires the proper level of charged atoms (ions). Researchers suggest that tight junctions composed of claudin 14 help to maintain these ion levels.


Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.