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FUS FUS RNA binding protein [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001170634 Homo sapiens FUS RNA binding protein (FUS), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001170937 Homo sapiens FUS RNA binding protein (FUS), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_004960 Homo sapiens FUS RNA binding protein (FUS), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005255233 PREDICTED: Homo sapiens fused in sarcoma (FUS), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Related Services

Gene Symbol FUS
Entrez Gene ID 2521
Full Name FUS RNA binding protein
Synonyms ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS
General protein information
Preferred Names
RNA-binding protein FUS
Names
RNA-binding protein FUS
oncogene FUS
oncogene TLS
fus-like protein
75 kDa DNA-pairing protein
fusion gene in myxoid liposarcoma
translocated in liposarcoma protein
heterogeneous nuclear ribonucleoprotein P2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p11.2

Summary This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009].
Disorder

MIM: 137070

Amyotrophic lateral sclerosis 6, autosomal recessive, with or without

mRNA Protein Product Sequence Price Select
NM_001170634, 283135200 NP_001164105, 283135201 RNA-binding protein FUS isoform 2 ORF Sequence $550.00
NM_001170937, 283135172 NP_001164408, 283135173 RNA-binding protein FUS isoform 3 ORF Sequence $550.00
NM_004960, 270265814 NP_004951, 4826734 RNA-binding protein FUS isoform 1 ORF Sequence $550.00
XM_005255233, 578828504 XP_005255290, 530407875 RNA-binding protein FUS isoform X3 ORF Sequence $400.00
KEGG
hsa05202Transcriptional misregulation in cancer
WikiPathways
WP411mRNA processing
Reactome
REACT_71Gene Expression
REACT_1735mRNA Splicing
REACT_467mRNA Splicing - Major Pathway
REACT_125Processing of Capped Intron-Containing Pre-mRNA
Process
IDNameEvidence
GO:0000398mRNA splicing, via spliceosomeTAS
GO:0008219cell deathIEA
GO:0008380RNA splicingTAS
GO:0010467gene expressionTAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003677DNA bindingIEA
GO:0003723RNA bindingTAS
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GO:0042802identical protein bindingIPI
GO:0044822poly(A) RNA bindingIDA
GeneCards FUS
UniProt Q6IBQ5, P35637, Q13344
Vega OTTHUMG00000132395
MIM 137070
Ensembl ENSG00000089280
HGNC 4010
HPRD 00660

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FUS gene?

The FUS gene provides instructions for making a protein called fused in sarcoma (FUS). This protein is found within the cell nucleus in most tissues and is involved in many of the steps of protein production. The FUS protein attaches (binds) to DNA and regulates an activity called transcription, which is the first step in the production of proteins from genes. This protein also helps repair mistakes in DNA, which prevents cells from accumulating genetic damage.

The FUS protein is also involved in processing molecules called messenger RNA (mRNA), which serve as genetic blueprints for making proteins. By cutting and rearranging mRNA molecules in different ways, the FUS protein controls the production of different versions of certain proteins. This process is known as alternative splicing. Once the FUS protein processes the mRNA, it transports the mRNA out of the nucleus where it gets taken up by other cell structures to be further processed into a mature protein.

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