Sequence in raw or FASTA format:
FUS FUS RNA binding protein [Homo sapiens (human)]
|Entrez Gene ID||2521|
|Full Name||FUS RNA binding protein|
|Synonyms||ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009].|
Amyotrophic lateral sclerosis 6, autosomal recessive, with or without
|hsa05202||Transcriptional misregulation in cancer|
|REACT_467||mRNA Splicing - Major Pathway|
|REACT_125||Processing of Capped Intron-Containing Pre-mRNA|
|GO:0000398||mRNA splicing, via spliceosome||TAS|
|GO:0008270||zinc ion binding||IEA|
|GO:0042802||identical protein binding||IPI|
|GO:0044822||poly(A) RNA binding||IDA|
|UniProt||Q6IBQ5, P35637, Q13344|
What is the normal function of the FUS gene?
The FUS gene provides instructions for making a protein called fused in sarcoma (FUS). This protein is found within the cell nucleus in most tissues and is involved in many of the steps of protein production. The FUS protein attaches (binds) to DNA and regulates an activity called transcription, which is the first step in the production of proteins from genes. This protein also helps repair mistakes in DNA, which prevents cells from accumulating genetic damage.
The FUS protein is also involved in processing molecules called messenger RNA (mRNA), which serve as genetic blueprints for making proteins. By cutting and rearranging mRNA molecules in different ways, the FUS protein controls the production of different versions of certain proteins. This process is known as alternative splicing. Once the FUS protein processes the mRNA, it transports the mRNA out of the nucleus where it gets taken up by other cell structures to be further processed into a mature protein.
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