FUS fused in sarcoma [Homo sapiens (human)]
| Gene Symbol | FUS |
| Entrez Gene ID | 2521 |
| Full Name | fused in sarcoma |
| Synonyms | ALS6, FUS1, HNRNPP2, POMP75, TLS |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
16 16p11.2 |
| Summary | This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq]. |
| Disorder | MIM: 137070 Amyotrophic lateral sclerosis 6, autosomal recessive, with or without |
| mRNA | NM_004960, 270265814 |
| Protein | NP_004951, 4826734 |
| Product | RNA-binding protein FUS isoform 1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001170937, 283135172 |
| Protein | NP_001164408, 283135173 |
| Product | RNA-binding protein FUS isoform 3 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001170634, 283135200 |
| Protein | NP_001164105, 283135201 |
| Product | RNA-binding protein FUS isoform 2 |
| RefSeq Status | REVIEWED |
| WP411 | mRNA processing |
Reactome
| REACT_1735 | mRNA Splicing |
| REACT_1675 | mRNA Processing |
| REACT_467 | mRNA Splicing - Major Pathway |
| REACT_125 | Processing of Capped Intron-Containing Pre-mRNA |
| REACT_2039 | Formation and Maturation of mRNA Transcript |
| REACT_71 | Gene Expression |
| Homo sapiens (human) | FUS | NP_001164408.1 |
| Pan troglodytes (chimpanzee) | FUS | XP_001158561.1 |
| Bos taurus (cattle) | FUS | NP_776337.1 |
| Mus musculus (house mouse) | Fus | NP_631888.1 |
| Rattus norvegicus (Norway rat) | Fus | NP_001012137.1 |
| Danio rerio (zebrafish) | fus | NP_957377.2 |
| Drosophila melanogaster (fruit fly) | caz | NP_523365.2 |
| Caenorhabditis elegans | C27H5.3 | NP_495483.1 |
| ID | Name | Evidence |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | TAS |
| GO:0008219 | cell death | IEA |
| GO:0008380 | RNA splicing | EXP |
| GO:0010467 | gene expression | TAS |
Component
| ID | Name | Evidence |
| GO:0005622 | intracellular | IEA |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005730 | nucleolus | IDA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0003677 | DNA binding | IEA |
| GO:0003723 | RNA binding | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008270 | zinc ion binding | IEA |
| GO:0046872 | metal ion binding | IEA |
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