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FUS fused in sarcoma [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001170634 Homo sapiens fused in sarcoma (FUS), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001170937 Homo sapiens fused in sarcoma (FUS), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_004960 Homo sapiens fused in sarcoma (FUS), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol FUS
Entrez Gene ID 2521
Full Name fused in sarcoma
Synonyms ALS6, FUS1, HNRNPP2, POMP75, TLS
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p11.2

Summary This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009].
Disorder

MIM: 137070

Amyotrophic lateral sclerosis 6, autosomal recessive, with or without

mRNA Protein Product Sequence Price Select
NM_001170634, 283135200 NP_001164105, 283135201 RNA-binding protein FUS isoform 2 ORF Sequence $550.00
NM_001170937, 283135172 NP_001164408, 283135173 RNA-binding protein FUS isoform 3 ORF Sequence $550.00
NM_004960, 270265814 NP_004951, 4826734 RNA-binding protein FUS isoform 1 ORF Sequence $550.00
KEGG
hsa05202Transcriptional misregulation in cancer
WikiPathways
WP411mRNA processing
Reactome
REACT_71Gene Expression
REACT_467mRNA Splicing - Major Pathway
REACT_1735mRNA Splicing
REACT_125Processing of Capped Intron-Containing Pre-mRNA
Homo sapiens (human)FUSNP_001164105.1
Macaca mulatta (Rhesus monkey)LOC713433XP_001112691.1
Bos taurus (cattle)FUSNP_776337.1
Mus musculus (house mouse)FusNP_631888.1
Rattus norvegicus (Norway rat)FusNP_001012137.1
Gallus gallus (chicken)FUSNP_001001531.1
Danio rerio (zebrafish)fusNP_957377.2
Drosophila melanogaster (fruit fly)cazNP_523365.2
Caenorhabditis elegansfust-1NP_495483.1
Arabidopsis thaliana (thale cress)TAF15bNP_851215.1
GeneCards FUS
PDB 4FDD, 2LCW, 2LA6
UniProt Q6IBQ5, P35637, Q13344
MIM 137070
Ensembl ENSG00000089280
HGNC 4010
HPRD 00660

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
RNA-binding protein FUS
Names
RNA-binding protein FUS
oncogene FUS
oncogene TLS
fus-like protein
75 kDa DNA-pairing protein
fusion gene in myxoid liposarcoma
translocated in liposarcoma protein
heterogeneous nuclear ribonucleoprotein P2

Interactant



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