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FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_000150 Homo sapiens fucosyltransferase 6 (alpha (1,3) fucosyltransferase) (FUT6), transcript variant 1, mRNA. Full Length $1097.95
ORF Sequence $313.20
NM_001040701 Homo sapiens fucosyltransferase 6 (alpha (1,3) fucosyltransferase) (FUT6), transcript variant 2, mRNA. Full Length $1053.15
ORF Sequence $313.20


Gene Symbol FUT6
Entrez Gene ID 2528
Full Name fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
Synonyms FCT3A, FLJ40754, FT1A, Fuc-TVI, FucT-VI
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.3
Summary The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Disorder

MIM: 136836

Fucosyltransferase-6 deficiency (3)
mRNA NM_000150, 103472034
Protein NP_000141, 4503815
Product alpha-(1,3)-fucosyltransferase
RefSeq Status REVIEWED
mRNA NM_001040701, 103472032
Protein NP_001035791, 103472033
Product alpha-(1,3)-fucosyltransferase
RefSeq Status REVIEWED
KEGG
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
Homo sapiens (human)FUT6NP_000141.1
Pan troglodytes (chimpanzee)FUT6NP_001009150.1
Caenorhabditis elegansfut-6NP_494823.2
Caenorhabditis elegansfut-5NP_001022310.1
Caenorhabditis elegansfut-4NP_494372.2
Process
IDNameEvidence
GO:0006486protein glycosylationTAS
GO:0042355L-fucose catabolic processNAS
Component
IDNameEvidence
GO:0005794Golgi apparatusTAS
GO:0016020membraneIEA
GO:0016021integral to membraneIEA
GO:0032580Golgi cisterna membraneIEA
Function
IDNameEvidence
GO:0008417fucosyltransferase activityTAS
GO:0016757transferase activity, transferring glycosyl groupsIEA
GO:00170603-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activityIEA
GO:0046920alpha(1,3)-fucosyltransferase activityTAS
GeneCards FUT6
UniProt P51993, Q6P7E6
MIM 136836
Ensembl ENSG00000156413
HGNC 4017
HPRD 00651

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