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G6PD glucose-6-phosphate dehydrogenase [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000402 Homo sapiens glucose-6-phosphate dehydrogenase (G6PD), transcript variant 1, mRNA. ORF Sequence $475.02
Peptide Services
Antibody Services
Protein Services
NM_001042351 Homo sapiens glucose-6-phosphate dehydrogenase (G6PD), transcript variant 2, mRNA. ORF Sequence $448.92
Peptide Services
Antibody Services
Protein Services


Gene Symbol G6PD
Entrez Gene ID 2539
Full Name glucose-6-phosphate dehydrogenase
Synonyms G6PD1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq28

Summary This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 305900

G6PD deficiency (3); Favism (3); Hemolytic anemia due

mRNA Protein Product Sequence Price Select
NM_000402, 108773794 NP_000393, 109389365 glucose-6-phosphate 1-dehydrogenase isoform a Full Length $694.55
ORF Sequence $475.02
NM_001042351, 108773792 NP_001035810, 108773793 glucose-6-phosphate 1-dehydrogenase isoform b Full Length $658.30
ORF Sequence $448.92
KEGG
hsa00480Glutathione metabolism
hsa_M00006Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
hsa_M00004Pentose phosphate pathway (Pentose phosphate cycle)
hsa00030Pentose phosphate pathway
WikiPathways
WP692Sulfation Biotransformation Reaction
WP100Glutathione metabolism
WP134Pentose Phosphate Pathway
BIOCYC
HUMAN_OXIDATIVEPENT-PWYpentose phosphate pathway (oxidative branch)
HUMAN_PENTOSE-P-PWYpentose phosphate pathway
Reactome
REACT_1859Pentose phosphate pathway (hexose monophosphate shunt)
REACT_474Metabolism of carbohydrates
REACT_111217Metabolism
Homo sapiens (human)G6PDNP_000393.4
Macaca mulatta (Rhesus monkey)G6PDXP_001095382.1
Canis lupus familiaris (dog)G6PDXP_538209.2
Bos taurus (cattle)G6PDNP_001231064.1
Mus musculus (house mouse)G6pdxNP_032088.1
Rattus norvegicus (Norway rat)G6pdNP_058702.1
Danio rerio (zebrafish)g6pdXP_699168.3
Drosophila melanogaster (fruit fly)ZwNP_523411.1
Caenorhabditis elegansgspd-1NP_502129.1
Arabidopsis thaliana (thale cress)G6PD5NP_001030780.1
Arabidopsis thaliana (thale cress)G6PD6NP_198892.1
GeneCards G6PD
PDB 2BH9, 2BHL, 1QKI
UniProt P11413
MIM 305900
Ensembl ENSG00000160211
HGNC 4057
HPRD 02377

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
glucose-6-phosphate 1-dehydrogenase
Names
glucose-6-phosphate 1-dehydrogenase
glucose-6-phosphate dehydrogenase, G6PD
NP_000393.4
NP_001035810.1

Interactant

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