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G6PD glucose-6-phosphate dehydrogenase [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000402 Homo sapiens glucose-6-phosphate dehydrogenase (G6PD), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001042351 Homo sapiens glucose-6-phosphate dehydrogenase (G6PD), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005274657 PREDICTED: Homo sapiens glucose-6-phosphate dehydrogenase (G6PD), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005274658 PREDICTED: Homo sapiens glucose-6-phosphate dehydrogenase (G6PD), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol G6PD
Entrez Gene ID 2539
Full Name glucose-6-phosphate dehydrogenase
Synonyms G6PD1
General protein information
Preferred Names
glucose-6-phosphate 1-dehydrogenase
glucose-6-phosphate 1-dehydrogenase
glucose-6-phosphate dehydrogenase, G6PD
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

MIM: 305900

G6PD deficiency (3); Favism (3); Hemolytic anemia due

mRNA Protein Product Sequence Price Select
NM_000402, 544063453 NP_000393, 109389365 glucose-6-phosphate 1-dehydrogenase isoform a ORF Sequence $550.00
NM_001042351, 544063454 NP_001035810, 108773793 glucose-6-phosphate 1-dehydrogenase isoform b ORF Sequence $550.00
XM_005274657, 578838829 XP_005274714, 530422747 glucose-6-phosphate 1-dehydrogenase isoform X1 ORF Sequence $550.00
XM_005274658, 578838830 XP_005274715, 530422749 glucose-6-phosphate 1-dehydrogenase isoform X2 ORF Sequence $550.00
hsa00030Pentose phosphate pathway
hsa00480Glutathione metabolism
hsa_M00006Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
hsa_M00004Pentose phosphate pathway (Pentose phosphate cycle)
hsa01200Carbon metabolism
WP100Glutathione metabolism
WP134Pentose Phosphate Pathway
WP692Sulfation Biotransformation Reaction
HUMAN_PENTOSE-P-PWYpentose phosphate pathway
HUMAN_OXIDATIVEPENT-PWYpentose phosphate pathway (oxidative branch)
META_OXIDATIVEPENT-PWY-1pentose phosphate pathway (oxidative branch) II
REACT_1859Pentose phosphate pathway (hexose monophosphate shunt)
REACT_474Metabolism of carbohydrates
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)G6PDNP_000393.4
Macaca mulatta (Rhesus monkey)G6PDXP_001095382.1
Canis lupus familiaris (dog)G6PDXP_538209.2
Bos taurus (cattle)G6PDNP_001231064.1
Mus musculus (house mouse)G6pdxNP_032088.1
Rattus norvegicus (Norway rat)G6pdNP_058702.1
Danio rerio (zebrafish)g6pdXP_699168.3
Drosophila melanogaster (fruit fly)ZwNP_523411.1
Caenorhabditis elegansgspd-1NP_502129.1
Arabidopsis thaliana (thale cress)G6PD5NP_001030780.1
Arabidopsis thaliana (thale cress)G6PD6NP_198892.1
Xenopus (Silurana) tropicalis (western clawed frog)g6pdNP_001017312.1
GO:0001816cytokine productionIMP
GO:0005975carbohydrate metabolic processTAS
GO:0006098pentose-phosphate shuntIDA
GO:0006098pentose-phosphate shuntTAS
GO:0006629lipid metabolic processTAS
GO:0006695cholesterol biosynthetic processIMP
GO:0006739NADP metabolic processIDA
GO:0006740NADPH regenerationIMP
GO:0006749glutathione metabolic processIMP
GO:0009051pentose-phosphate shunt, oxidative branchIMP
GO:0010734negative regulation of protein glutathionylationIMP
GO:0014070response to organic cyclic compoundIEA
GO:0019322pentose biosynthetic processIDA
GO:0021762substantia nigra developmentIEP
GO:0032094response to foodIEA
GO:0034599cellular response to oxidative stressIMP
GO:0043249erythrocyte maturationIMP
GO:0043523regulation of neuron apoptotic processIEA
GO:0044281small molecule metabolic processTAS
GO:0045471response to ethanolIEA
GO:0046390ribose phosphate biosynthetic processIMP
GO:0051156glucose 6-phosphate metabolic processIDA
GO:0051156glucose 6-phosphate metabolic processIMP
GO:0055114oxidation-reduction processIMP
GO:0009898cytoplasmic side of plasma membraneIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0004345glucose-6-phosphate dehydrogenase activityIDA
GO:0004345glucose-6-phosphate dehydrogenase activityIMP
GO:0005515protein bindingIPI
GO:0005536glucose bindingIDA
GO:0005536glucose bindingIMP
GO:0042803protein homodimerization activityIPI
GO:0050661NADP bindingIDA
GeneCards G6PD
UniProt P11413
Vega OTTHUMG00000024237
MIM 305900
Ensembl ENSG00000160211
HGNC 4057
HPRD 02377

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the G6PD gene?

The G6PD gene provides instructions for making an enzyme called glucose-6-phosphate dehydrogenase. This enzyme, which is active in virtually all types of cells, is involved in the normal processing of carbohydrates. It plays a critical role in red blood cells, which carry oxygen from the lungs to tissues throughout the body. This enzyme helps protect red blood cells from damage and premature destruction.

Glucose-6-phosphate dehydrogenase is responsible for the first step in a chemical pathway that converts glucose (a type of sugar found in most carbohydrates) to ribose-5-phosphate. Ribose-5-phosphate is an important component of nucleotides, which are the building blocks of DNA and its chemical cousin RNA. This chemical reaction produces a molecule called NADPH, which plays a role in protecting cells from potentially harmful molecules called reactive oxygen species. These molecules are byproducts of normal cellular functions. Reactions involving NADPH produce compounds that prevent reactive oxygen species from building up to toxic levels within cells. The production of NADPH by glucose-6-phosphate dehydrogenase is essential in red blood cells, which are particularly susceptible to damage by reactive oxygen species because they lack other NADPH-producing enzymes.


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