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SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001164277 Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4 (SLC37A4), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001164278 Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4 (SLC37A4), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001164279 Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4 (SLC37A4), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001164280 Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4 (SLC37A4), transcript variant 5, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001467 Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4 (SLC37A4), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Gene Symbol SLC37A4
Entrez Gene ID 2542
Full Name solute carrier family 37 (glucose-6-phosphate transporter), member 4
Synonyms G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, TRG-19, TRG19
General protein information
Preferred Names
glucose-6-phosphate translocase
Names
glucose-6-phosphate translocase
glucose-5-phosphate transporter
solute carrier family 37 member 4
transformation-related gene 19 protein
microsomal glucose-6-phosphate transporter
glucose-6-phosphatase, transport (glucose) protein 3
glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1
glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23.3

Summary This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009].
Disorder

MIM: 602671

Glycogen storage disease Ib, 232220 (3); Glycogen storage disease Ic,

mRNA Protein Product Sequence Price Select
NM_001164277, 256219482 NP_001157749, 256219483 glucose-6-phosphate translocase isoform 1 ORF Sequence $360.00
NM_001164278, 256219542 NP_001157750, 256219543 glucose-6-phosphate translocase isoform 2 ORF Sequence $550.00
NM_001164279, 256219563 NP_001157751, 256219564 glucose-6-phosphate translocase isoform 3 ORF Sequence $269.00
NM_001164280, 256219597 NP_001157752, 256219598 glucose-6-phosphate translocase isoform 1 ORF Sequence $360.00
NM_001467, 256219591 NP_001458, 4503847 glucose-6-phosphate translocase isoform 1 ORF Sequence $360.00
KEGG
hsa04973Carbohydrate digestion and absorption
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_212Glucose transport
REACT_9441Hexose transport
REACT_474Metabolism of carbohydrates
REACT_15518Transmembrane transport of small molecules
REACT_111217Metabolism
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)SLC37A4NP_001157750.1
Pan troglodytes (chimpanzee)SLC37A4XP_508803.2
Macaca mulatta (Rhesus monkey)SLC37A4XP_001100471.1
Canis lupus familiaris (dog)SLC37A4XP_546493.2
Bos taurus (cattle)SLC37A4NP_001192279.1
Mus musculus (house mouse)Slc37a4NP_032089.2
Rattus norvegicus (Norway rat)Slc37a4NP_113777.2
Gallus gallus (chicken)SLC37A4XP_001233002.1
Danio rerio (zebrafish)slc37a4XP_005169262.1
Danio rerio (zebrafish)slc37a4bNP_957234.1
Xenopus (Silurana) tropicalis (western clawed frog)slc37a4NP_001017356.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0006006glucose metabolic processNAS
GO:0006810transportNAS
GO:0008645hexose transportTAS
GO:0015758glucose transportTAS
GO:0015760glucose-6-phosphate transportIDA
GO:0015760glucose-6-phosphate transportIMP
GO:0042593glucose homeostasisIDA
GO:0044281small molecule metabolic processTAS
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005783endoplasmic reticulumNAS
GO:0005789endoplasmic reticulum membraneTAS
GO:0016020membraneIDA
GO:0016021integral component of membraneNAS
GO:0030176integral component of endoplasmic reticulum membraneIDA
Function
IDNameEvidence
GO:0005215transporter activityNAS
GO:0015152glucose-6-phosphate transmembrane transporter activityIDA
GO:0015152glucose-6-phosphate transmembrane transporter activityIMP
GeneCards SLC37A4
UniProt O43826, B4DUH2, A8K0S7
MIM 602671
Ensembl ENSG00000137700
HGNC 4061
HPRD 04052

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SLC37A4 gene?

The SLC37A4 gene provides instructions for making a protein called glucose 6-phosphate translocase. This protein transports the sugar molecule glucose 6-phosphate from the fluid inside the cell (cytoplasm) to the endoplasmic reticulum, which is a structure inside cells that is involved in protein processing and transport. At the membrane of the endoplasmic reticulum, glucose 6-phosphate translocase works together with the glucose 6-phosphatase protein (produced from the G6PC gene) to break down glucose 6-phosphate. The breakdown of this molecule produces the simple sugar glucose, which is the primary energy source for most cells in the body.

Interactant

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