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GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17601 NM_000812 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17601C NM_000812 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol GABRB1
Entrez Gene ID 2560
Full Name gamma-aminobutyric acid (GABA) A receptor, beta 1
Synonyms
General protein information
Preferred Names
gamma-aminobutyric acid receptor subunit beta-1
Names
gamma-aminobutyric acid receptor subunit beta-1
GABA(A) receptor, beta 1
GABA(A) receptor subunit beta-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p12

Summary The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008].
Disorder

MIM: 137190

mRNA Protein Product Sequence Price Select
NM_000812, 194097326 NP_000803, 194097327 gamma-aminobutyric acid receptor subunit beta-1 precursor ORF Sequence $550.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04727GABAergic synapse
hsa04726Serotonergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa05033Nicotine addiction
hsa05032Morphine addiction
Reactome
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_13685Neuronal System
REACT_24987GABA A receptor activation
REACT_25199GABA receptor activation
REACT_25300Ion channel transport
REACT_25387Ligand-gated ion channel transport
Homo sapiens (human)GABRB1NP_000803.2
Pan troglodytes (chimpanzee)GABRB1XP_001154620.1
Macaca mulatta (Rhesus monkey)GABRB1XP_002804095.1
Canis lupus familiaris (dog)GABRB1XP_005628215.1
Bos taurus (cattle)GABRB1NP_776969.1
Mus musculus (house mouse)Gabrb1NP_032095.1
Rattus norvegicus (Norway rat)Gabrb1NP_037088.1
Gallus gallus (chicken)GABRQNP_001161175.1
Danio rerio (zebrafish)gabrb1XP_002664179.2
Xenopus (Silurana) tropicalis (western clawed frog)gabrb1XP_004911268.1
Process
IDNameEvidence
GO:0006810transportTAS
GO:0006811ion transportISS
GO:0007165signal transductionTAS
GO:0007268synaptic transmissionTAS
GO:0034220ion transmembrane transportTAS
GO:0055085transmembrane transportTAS
GO:0071420cellular response to histamineISS
GO:1902476chloride transmembrane transportIEA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneISS
GO:0030054cell junctionIEA
GO:0034707chloride channel complexIEA
GO:0045211postsynaptic membraneIEA
GO:1902711GABA-A receptor complexISS
Function
IDNameEvidence
GO:0004890GABA-A receptor activityISS
GO:0005230extracellular ligand-gated ion channel activityIEA
GO:0005254chloride channel activityIEA
GO:0015276ligand-gated ion channel activityISS
GeneCards GABRB1
UniProt X5DNL6, P18505
Vega OTTHUMG00000044269
MIM 137190
Ensembl ENSG00000163288
HGNC 4081
HPRD 15924

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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