GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 [Homo sapiens (human)]
| Gene Symbol | GABRB1 |
| Entrez Gene ID | 2560 |
| Full Name | gamma-aminobutyric acid (GABA) A receptor, beta 1 |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
4 4p12 |
| Summary | The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq]. |
| Disorder | MIM: 137190 |
| mRNA | NM_000812, 194097326 |
| Protein | NP_000803, 194097327 |
| Product | gamma-aminobutyric acid receptor subunit beta-1 precursor |
| RefSeq Status | REVIEWED |
| hsa04080 | Neuroactive ligand-receptor interaction |
Reactome
| REACT_15518 | Transmembrane transport of small molecules |
| REACT_25199 | GABA receptor activation |
| REACT_13477 | Transmission across Chemical Synapses |
| REACT_25300 | Ion channel transport |
| REACT_24987 | GABA A receptor activation |
| REACT_15370 | Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
| REACT_25387 | Ligand-gated ion channel transport |
| REACT_13685 | Synaptic Transmission |
| Homo sapiens (human) | GABRB1 | NP_000803.2 |
| Pan troglodytes (chimpanzee) | GABRB1 | XP_001154620.1 |
| Bos taurus (cattle) | GABRB1 | NP_776969.1 |
| Mus musculus (house mouse) | Gabrb1 | NP_032095.1 |
| Rattus norvegicus (Norway rat) | Gabrb1 | NP_037088.1 |
| Danio rerio (zebrafish) | LOC100331377 | XP_002664179.1 |
| ID | Name | Evidence |
| GO:0006810 | transport | TAS |
| GO:0007165 | signal transduction | TAS |
| GO:0007268 | synaptic transmission | TAS |
| GO:0034220 | ion transmembrane transport | TAS |
| GO:0055085 | transmembrane transport | TAS |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | TAS |
| GO:0005887 | integral to plasma membrane | TAS |
| GO:0030054 | cell junction | IEA |
| GO:0034707 | chloride channel complex | IEA |
| GO:0045202 | synapse | IEA |
| GO:0045211 | postsynaptic membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0004872 | receptor activity | IEA |
| GO:0004890 | GABA-A receptor activity | IEA |
| GO:0005216 | ion channel activity | IEA |
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA |
| GO:0005254 | chloride channel activity | IEA |
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