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GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17503 NM_198904 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17585 NM_000816 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18155 NM_198903 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17503C NM_198904 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu17585C NM_000816 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu18155C NM_198903 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol GABRG2
Entrez Gene ID 2566
Full Name gamma-aminobutyric acid (GABA) A receptor, gamma 2
Synonyms CAE2, ECA2, GEFSP3
General protein information
Preferred Names
gamma-aminobutyric acid receptor subunit gamma-2
Names
gamma-aminobutyric acid receptor subunit gamma-2
GABA(A) receptor, gamma 2
GABA(A) receptor subunit gamma-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q34

Summary This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 137164

Epilepsy, generalized, with febrile seizures plus, type 3, 604233

mRNA Protein Product Sequence Price Select
NM_000816, 189083760 NP_000807, 38788135 gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor ORF Sequence $550.00
NM_198903, 189083761 NP_944493, 189083762 gamma-aminobutyric acid receptor subunit gamma-2 isoform 3 precursor ORF Sequence $550.00
NM_198904, 189083759 NP_944494, 38788155 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor ORF Sequence $550.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04727GABAergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa05033Nicotine addiction
hsa05032Morphine addiction
Reactome
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_13685Neuronal System
REACT_24987GABA A receptor activation
REACT_25199GABA receptor activation
REACT_25300Ion channel transport
REACT_25387Ligand-gated ion channel transport
Homo sapiens (human)GABRG2NP_944493.2
Pan troglodytes (chimpanzee)GABRG2XP_003311017.2
Macaca mulatta (Rhesus monkey)GABRG2XP_002804663.1
Canis lupus familiaris (dog)GABRG2XP_867037.1
Bos taurus (cattle)GABRG2NP_776970.1
Mus musculus (house mouse)Gabrg2NP_032099.1
Rattus norvegicus (Norway rat)Gabrg2NP_899156.1
Gallus gallus (chicken)GABRG2NP_990676.1
Danio rerio (zebrafish)gabrg2NP_001243179.1
Xenopus (Silurana) tropicalis (western clawed frog)gabrg2XP_002941681.1
Process
IDNameEvidence
GO:0006810transportTAS
GO:0007214gamma-aminobutyric acid signaling pathwayIEA
GO:0007268synaptic transmissionTAS
GO:0009791post-embryonic developmentIEA
GO:0030534adult behaviorIEA
GO:0034220ion transmembrane transportTAS
GO:0051932synaptic transmission, GABAergicISS
GO:0055085transmembrane transportTAS
GO:0071420cellular response to histamineISS
GO:1902476chloride transmembrane transportIEA
GO:1902476chloride transmembrane transportISS
Component
IDNameEvidence
GO:0005737cytoplasmIEA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneISS
GO:0030054cell junctionIEA
GO:0030424axonIEA
GO:0032590dendrite membraneISS
GO:0034707chloride channel complexIEA
GO:0045211postsynaptic membraneIEA
GO:0060077inhibitory synapseIEA
GO:1902711GABA-A receptor complexISS
Function
IDNameEvidence
GO:0004890GABA-A receptor activityISS
GO:0005230extracellular ligand-gated ion channel activityIEA
GO:0005254chloride channel activityISS
GO:0005515protein bindingIPI
GO:0008503benzodiazepine receptor activityTAS
GeneCards GABRG2
UniProt P18507
Vega OTTHUMG00000130350
MIM 137164
Ensembl ENSG00000113327
HGNC 4087
HPRD 00663

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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