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POU2F3 POU class 2 homeobox 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001244682 Homo sapiens POU class 2 homeobox 3 (POU2F3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_014352 Homo sapiens POU class 2 homeobox 3 (POU2F3), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Related Services

Gene Symbol POU2F3
Entrez Gene ID 25833
Full Name POU class 2 homeobox 3
Synonyms Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23.3

Summary This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
Disorder

MIM: 607394

mRNA Protein Product Sequence Price Select
NM_001244682, 347658963 NP_001231611, 347658964 POU domain, class 2, transcription factor 3 isoform 2 ORF Sequence $550.00
NM_014352, 347658962 NP_055167, 148664218 POU domain, class 2, transcription factor 3 isoform 1 ORF Sequence $360.00
KEGG
hsa05168Herpes simplex infection
Homo sapiens (human)POU2F3NP_055167.2
Pan troglodytes (chimpanzee)POU2F3XP_001151894.3
Macaca mulatta (Rhesus monkey)POU2F3XP_001100709.2
Canis lupus familiaris (dog)POU2F3XP_005619723.1
Bos taurus (cattle)POU2F3NP_001192759.1
Mus musculus (house mouse)Pou2f3NP_035269.2
Rattus norvegicus (Norway rat)Pou2f3NP_001099215.1
Gallus gallus (chicken)POU2F3XP_425799.4
Danio rerio (zebrafish)pou2f3NP_001038720.2
Xenopus (Silurana) tropicalis (western clawed frog)pou2f3XP_002935067.2
Process
IDNameEvidence
GO:0006351transcription, DNA-templatedIEA
GO:0006357regulation of transcription from RNA polymerase II promoterTAS
GO:0008544epidermis developmentTAS
GO:0030216keratinocyte differentiationIEA
GO:0042060wound healingIEA
GO:0043922negative regulation by host of viral transcriptionIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005667transcription factor complexIEA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
Function
IDNameEvidence
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIMP
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDA
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIMP
GO:0005515protein bindingIPI
GO:0043565sequence-specific DNA bindingIDA
GO:0046983protein dimerization activityIEA
GeneCards POU2F3
UniProt Q9UKI9
Vega OTTHUMG00000166140
MIM 607394
Ensembl ENSG00000137709
HGNC 19864
HPRD 09582

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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