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GALR1 galanin receptor 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001480 Homo sapiens galanin receptor 1 (GALR1), mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Related Services

Gene Symbol GALR1
Entrez Gene ID 2587
Full Name galanin receptor 1
Synonyms GALNR, GALNR1
General protein information
Preferred Names
galanin receptor type 1
Names
galanin receptor type 1
GAL1-R
GALR-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

18

18q23

Summary The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600377

mRNA Protein Product Sequence Price Select
NM_001480, 167000884 NP_001471, 167000885 galanin receptor type 1 ORF Sequence $400.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
WikiPathways
WP455GPCRs, Class A Rhodopsin-like
WP24Peptide GPCRs
Reactome
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
Homo sapiens (human)GALR1NP_001471.2
Pan troglodytes (chimpanzee)GALR1XP_523975.2
Macaca mulatta (Rhesus monkey)GALR1XP_001086740.1
Canis lupus familiaris (dog)GALR1XP_541048.2
Bos taurus (cattle)GALR1NP_001179170.1
Mus musculus (house mouse)Galr1NP_032108.1
Rattus norvegicus (Norway rat)Galr1NP_037090.2
Gallus gallus (chicken)GALR1NP_001121534.1
Danio rerio (zebrafish)galr1XP_696215.1
Caenorhabditis elegansCELE_Y54E2A.1NP_497057.2
Xenopus (Silurana) tropicalis (western clawed frog)galr1NP_001107355.1
Process
IDNameEvidence
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathwayIEA
GO:0007194negative regulation of adenylate cyclase activityIEA
GO:0007204positive regulation of cytosolic calcium ion concentrationIEA
GO:0007218neuropeptide signaling pathwayTAS
GO:0007586digestionTAS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0051464positive regulation of cortisol secretionIMP
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0004966galanin receptor activityIDA
GO:0005515protein bindingIPI
GO:0017046peptide hormone bindingIDA
GO:0042923neuropeptide bindingIEA
GeneCards GALR1
UniProt P47211
MIM 600377
HGNC 4132
HPRD 02657

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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