Sequence in raw or FASTA format:
GALR1 galanin receptor 1 [
Homo sapiens (human)]
Gene Symbol GALR1
Entrez Gene ID
Full Name galanin receptor 1
Synonyms GALNR, GALNR1
General protein information
galanin receptor type 1
galanin receptor type 1
Gene Type protein-coding
Homo sapiens (human)
Chromosome:18 Map Location:18q23
Summary The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008].
hsa04080 Neuroactive ligand-receptor interaction
WP455 GPCRs, Class A Rhodopsin-like
WP24 Peptide GPCRs
ID Name Evidence
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
GO:0007194 negative regulation of adenylate cyclase activity IEA
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA
GO:0007218 neuropeptide signaling pathway TAS
GO:0007586 digestion TAS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0051464 positive regulation of cortisol secretion IMP
Related articles in PubMed Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661. Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer. Stevenson L, et al. Clin Cancer Res, 2012 Oct 1. PMID 22859720. The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence. Jackson KJ, et al. Neuropsychopharmacology, 2011 Oct. PMID 21796100. The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment. Lori A, et al. Neuropsychopharmacology, 2011 Jun. PMID 21430647. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086. See all (30) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Moreover, we have identified a novel role for the GalR1/galanin receptor-ligand axis in chemoresistance, providing evidence to support its further evaluation as a potential therapeutic target and biomarker in colorectal cancer .
Title: Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer.
Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence.
Title: The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence.
The results of this study suggested an association between variation at the GALR1 locus and baseline craving for tobacco in smokers seeking cessation treatment.
Title: The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
it has been demonstrated that GalR1-5-HT1A receptors heteromerize.
Title: Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Human variation in alcohol response is influenced by variation in neuronal signaling genes.
GAL, coding for the neuropeptide galanin, and GALR1, a galanin receptor, were identified as candidate genes of oncogenesis in squamous cell carcinoma using a survey of parallel chromosomal alterations and gene expression studies in 10 SCC cell lines.
Title: The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.
GALR1 is a tumor suppressor gene in head and neck squamous cell carcinoma
Title: Epigenetic inactivation of galanin receptor 1 in head and neck cancer.
GalR1 is internalized via the clathrin-dependent, endocytic pathway and then, to a large extent, delivered to lysosomes for degradation through the lysosome-targeting signal YXXO
Title: Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic terminus.
Data suggest that galanin stimulates cortisol secretion from human inner adrenocortical cells, acting through GAL-R1 coupled to the adenylate cyclase/PKA-dependent signaling cascade via a Ptx-sensitive Galpha protein.
Title: Galanin stimulates cortisol secretion from human adrenocortical cells through the activation of galanin receptor subtype 1 coupled to the adenylate cyclase-dependent signaling cascade.
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