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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004482 Homo sapiens polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005246449 PREDICTED: Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (GALNT3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006712402 PREDICTED: Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (GALNT3), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

Related Services

Gene Symbol GALNT3
Entrez Gene ID 2591
Full Name polypeptide N-acetylgalactosaminyltransferase 3
Synonyms GalNAc-T3, HFTC, HHS
General protein information
Preferred Names
polypeptide N-acetylgalactosaminyltransferase 3
Names
polypeptide N-acetylgalactosaminyltransferase 3
pp-GaNTase 3
GalNAc transferase 3
polypeptide GalNAc transferase 3
polypeptide GalNAc-transferase T3
protein-UDP acetylgalactosaminyltransferase 3
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3
NP_004473.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q24-q31

Summary This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601756

Tumoral calcinosis, hyperphosphatemic, familial, 211900 (3)

mRNA Protein Product Sequence Price Select
NM_004482, 153266877 NP_004473, 153266878 polypeptide N-acetylgalactosaminyltransferase 3 ORF Sequence $700.00
XM_005246449, 530370132 XP_005246506, 530370133 polypeptide N-acetylgalactosaminyltransferase 3 isoform X1 ORF Sequence $700.00
XM_006712402, 578804023 XP_006712465, 578804024 polypeptide N-acetylgalactosaminyltransferase 3 isoform X2 ORF Sequence $400.00
KEGG
hsa00512Mucin type O-Glycan biosynthesis
hsa_M00056O-glycan biosynthesis, mucin type core
Reactome
REACT_17015Metabolism of proteins
REACT_22161Post-translational protein modification
REACT_115606O-linked glycosylation of mucins
REACT_200727O-linked glycosylation
Homo sapiens (human)GALNT3NP_004473.2
Pan troglodytes (chimpanzee)GALNT3XP_515871.2
Macaca mulatta (Rhesus monkey)GALNT3XP_001096023.1
Canis lupus familiaris (dog)GALNT3XP_005640315.1
Bos taurus (cattle)GALNT3NP_001179787.1
Mus musculus (house mouse)Galnt3NP_056551.2
Rattus norvegicus (Norway rat)Galnt3NP_001015032.2
Gallus gallus (chicken)GALNT3XP_422023.2
Xenopus (Silurana) tropicalis (western clawed frog)galnt3XP_002936794.2
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processNAS
GO:0016266O-glycan processingTAS
GO:0018242protein O-linked glycosylation via serineIDA
GO:0018243protein O-linked glycosylation via threonineIDA
GO:0043687post-translational protein modificationTAS
GO:0044267cellular protein metabolic processTAS
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005794Golgi apparatusIDA
GO:0016020membraneTAS
GO:0016021integral component of membraneIEA
GO:0032580Golgi cisterna membraneIEA
GO:0048471perinuclear region of cytoplasmIDA
Function
IDNameEvidence
GO:0004653polypeptide N-acetylgalactosaminyltransferase activityIDA
GO:0005509calcium ion bindingIDA
GO:0030145manganese ion bindingIDA
GeneCards GALNT3
UniProt Q14435
Vega OTTHUMG00000132157
MIM 601756
Ensembl ENSG00000115339
HGNC 4125
HPRD 03453

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the GALNT3 gene?

The GALNT3 gene provides instructions for making a protein called ppGalNacT3, which is found in many types of cells. This protein plays a major role in regulating phosphate levels within the body (phosphate homeostasis). Among its many functions, phosphate plays a critical role in the formation and growth of bones in childhood and helps maintain bone strength in adults. Phosphate levels are controlled in large part by the kidneys. The kidneys normally rid the body of excess phosphate by excreting it in urine, and they reabsorb this mineral into the bloodstream when more is needed.

The ppGalNacT3 protein regulates the activity of a protein called fibroblast growth factor 23, which is produced in bone cells and whose function is to signal the body to decrease phosphate reabsorption by the kidneys. The ppGalNacT3 protein attaches sugar molecules to particular regions of fibroblast growth factor 23 through a process called glycosylation. These sugar molecules are required for the protein's transport out of cells and to protect the protein from being broken down. When phosphate levels are increased, ppGalNacT3 glycosylates fibroblast growth factor 23 so it will not be broken down. Signaling from fibroblast growth factor 23 leads to a decrease in phosphate reabsorption, which helps to maintain normal phosphate levels in the body.

Interactant

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