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GAPDH glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001256799 Homo sapiens glyceraldehyde-3-phosphate dehydrogenase (GAPDH), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_001289745 Homo sapiens glyceraldehyde-3-phosphate dehydrogenase (GAPDH), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001289746 Homo sapiens glyceraldehyde-3-phosphate dehydrogenase (GAPDH), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_002046 Homo sapiens glyceraldehyde-3-phosphate dehydrogenase (GAPDH), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Related Services

Gene Symbol GAPDH
Entrez Gene ID 2597
Full Name glyceraldehyde-3-phosphate dehydrogenase
Synonyms G3PD, GAPD, HEL-S-162eP
General protein information
Preferred Names
glyceraldehyde-3-phosphate dehydrogenase
Names
glyceraldehyde-3-phosphate dehydrogenase
aging-associated gene 9 protein
peptidyl-cysteine S-nitrosylase GAPDH
NP_001243728.1
NP_002037.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p13

Summary This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Disorder

MIM: 138400

mRNA Protein Product Sequence Price Select
NM_001256799, 576583514 NP_001243728, 378404908 glyceraldehyde-3-phosphate dehydrogenase isoform 2 ORF Sequence $199.00
NM_001289745, 576583518 NP_001276674, 576583519 glyceraldehyde-3-phosphate dehydrogenase isoform 1 ORF Sequence $400.00
NM_001289746, 576583523 NP_001276675, 576583524 glyceraldehyde-3-phosphate dehydrogenase isoform 1 ORF Sequence $400.00
NM_002046, 576583510 NP_002037, 7669492 glyceraldehyde-3-phosphate dehydrogenase isoform 1 ORF Sequence $269.00
KEGG
hsa00010Glycolysis / Gluconeogenesis
hsa05010Alzheimer's disease
hsa_M00003Gluconeogenesis, oxaloacetate => fructose-6P
hsa_M00002Glycolysis, core module involving three-carbon compounds
hsa_M00001Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa04066HIF-1 signaling pathway
hsa01230Biosynthesis of amino acids
hsa01200Carbon metabolism
WikiPathways
WP534Glycolysis and Gluconeogenesis
WP706SIDS Susceptibility Pathways
WP2059Alzheimers Disease
Pathway Interaction Database
myc_activpathwayValidated targets of C-MYC transcriptional activation
Reactome
REACT_1383Glycolysis
REACT_474Metabolism of carbohydrates
REACT_723Glucose metabolism
REACT_1520Gluconeogenesis
REACT_111217Metabolism
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)GAPDHNP_002037.2
Pan troglodytes (chimpanzee)GAPDHXP_508955.1
Macaca mulatta (Rhesus monkey)GAPDHXP_001105471.1
Canis lupus familiaris (dog)GAPDHNP_001003142.1
Canis lupus familiaris (dog)LOC100688969XP_003435697.1
Canis lupus familiaris (dog)LOC100683724XP_003434435.1
Bos taurus (cattle)GAPDHNP_001029206.1
Mus musculus (house mouse)GapdhNP_032110.1
Mus musculus (house mouse)Gm20899XP_001476757.1
Rattus norvegicus (Norway rat)GapdhNP_058704.1
Gallus gallus (chicken)GAPDHNP_989636.1
Danio rerio (zebrafish)gapdhNP_001108586.1
Drosophila melanogaster (fruit fly)Gapdh2NP_001259584.1
Drosophila melanogaster (fruit fly)Gapdh1NP_525108.2
Caenorhabditis elegansgpd-1NP_496237.1
Caenorhabditis elegansgpd-4NP_496192.1
Caenorhabditis elegansgpd-3NP_508534.3
Caenorhabditis elegansgpd-2NP_508535.1
Xenopus (Silurana) tropicalis (western clawed frog)gapdhNP_001004949.1
Process
IDNameEvidence
GO:0000226microtubule cytoskeleton organizationISS
GO:0005975carbohydrate metabolic processTAS
GO:0006006glucose metabolic processTAS
GO:0006094gluconeogenesisTAS
GO:0006096glycolytic processIEA
GO:0006096glycolytic processTAS
GO:0017148negative regulation of translationIDA
GO:0017148negative regulation of translationIMP
GO:0035606peptidyl-cysteine S-trans-nitrosylationISS
GO:0044281small molecule metabolic processTAS
GO:0050821protein stabilizationISS
GO:0051402neuron apoptotic processISS
GO:0055114oxidation-reduction processIEA
GO:0071346cellular response to interferon-gammaIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005634nucleusISS
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISS
GO:0005811lipid particleIDA
GO:0005829cytosolISS
GO:0005829cytosolTAS
GO:0005886plasma membraneIDA
GO:0015630microtubule cytoskeletonISS
GO:0016020membraneIDA
GO:0030529ribonucleoprotein complexIDA
GO:0048471perinuclear region of cytoplasmIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0097452GAIT complexIDA
Function
IDNameEvidence
GO:0004365glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activityISS
GO:0004365glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activityNAS
GO:0005515protein bindingIPI
GO:0008017microtubule bindingISS
GO:0035605peptidyl-cysteine S-nitrosylase activityISS
GO:0042802identical protein bindingIPI
GO:0050661NADP bindingIEA
GO:0051287NAD bindingIEA
GeneCards GAPDH
UniProt V9HVZ4, P04406
Vega OTTHUMG00000137379
MIM 138400
Ensembl ENSG00000111640
HGNC 4141
HPRD 00713

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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