GAPDH glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens (human)]
| Gene Symbol | GAPDH |
| Entrez Gene ID | 2597 |
| Full Name | glyceraldehyde-3-phosphate dehydrogenase |
| Synonyms | G3PD, GAPD, MGC88685 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
12 12p13 |
| Summary | The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. [provided by RefSeq]. |
| Disorder | MIM: 138400 |
| mRNA | NM_002046, 83641890 |
| Protein | NP_002037, 7669492 |
| Product | glyceraldehyde-3-phosphate dehydrogenase |
| RefSeq Status | REVIEWED |
| hsa00010 | Glycolysis / Gluconeogenesis |
| hsa01100 | Metabolic pathways |
| hsa05010 | Alzheimer's disease |
Pathway Interaction Database
| myc_activpathway | Validated targets of C-MYC transcriptional activation |
WikiPathways
| WP138 | Androgen Receptor Signaling Pathway |
Reactome
| REACT_474 | Metabolism of carbohydrates |
| REACT_1383 | Glycolysis |
| REACT_1520 | Gluconeogenesis |
| REACT_723 | Glucose metabolism |
| Homo sapiens (human) | GAPDH | NP_002037.2 |
| Pan troglodytes (chimpanzee) | GAPDH | XP_001162057.1 |
| Canis lupus familiaris (dog) | GAPDH | NP_001003142.1 |
| Bos taurus (cattle) | GAPDH | XP_001252512.1 |
| Bos taurus (cattle) | GAPDH | NP_001029206.1 |
| Mus musculus (house mouse) | Gm13882 | XP_001479901.1 |
| Rattus norvegicus (Norway rat) | Gapdh | NP_058704.1 |
| Rattus norvegicus (Norway rat) | Gapdh-ps2 | XP_001070653.1 |
| Rattus norvegicus (Norway rat) | LOC685186 | XP_001062726.1 |
| Rattus norvegicus (Norway rat) | RGD1565368 | XP_576394.1 |
| Gallus gallus (chicken) | GAPDH | NP_989636.1 |
| Danio rerio (zebrafish) | gapdh | NP_001108586.1 |
| Drosophila melanogaster (fruit fly) | Gapdh1 | NP_001033936.1 |
| Drosophila melanogaster (fruit fly) | Gapdh2 | NP_525091.1 |
| Caenorhabditis elegans | gpd-4 | NP_496192.1 |
| Caenorhabditis elegans | gpd-3 | NP_508534.3 |
| Caenorhabditis elegans | gpd-2 | NP_508535.1 |
| Caenorhabditis elegans | gpd-1 | NP_496237.1 |
| Arabidopsis thaliana (thale cress) | GAPCP-1 | NP_178071.1 |
| Arabidopsis thaliana (thale cress) | GAPCP-2 | NP_173080.1 |
| ID | Name | Evidence |
| GO:0005975 | carbohydrate metabolic process | TAS |
| GO:0006006 | glucose metabolic process | TAS |
| GO:0006094 | gluconeogenesis | TAS |
| GO:0006096 | glycolysis | NAS |
| GO:0006096 | glycolysis | TAS |
| GO:0035606 | peptidyl-cysteine S-trans-nitrosylation | ISS |
| GO:0050821 | protein stabilization | ISS |
| GO:0051402 | neuron apoptosis | ISS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | ISS |
| GO:0005737 | cytoplasm | NAS |
| GO:0005829 | cytosol | ISS |
| GO:0005829 | cytosol | TAS |
| GO:0016020 | membrane | IEA |
| GO:0048471 | perinuclear region of cytoplasm | IEA |
Function
| ID | Name | Evidence |
| GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | ISS |
| GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | NAS |
| GO:0005515 | protein binding | IPI |
| GO:0016491 | oxidoreductase activity | IEA |
| GO:0016740 | transferase activity | IEA |
| GO:0035605 | peptidyl-cysteine S-nitrosylase activity | ISS |
| GO:0051287 | NAD binding | IEA |
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