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PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001193431 Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_012411 Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_015967 Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005270738 PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Related Services

Gene Symbol PTPN22
Entrez Gene ID 26191
Full Name protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms LYP, LYP1, LYP2, PEP, PTPN8
General protein information
Preferred Names
tyrosine-protein phosphatase non-receptor type 22
Names
tyrosine-protein phosphatase non-receptor type 22
lymphoid phosphatase
PEST-domain phosphatase
lymphoid-specific protein tyrosine phosphatase
protein tyrosine phosphatase, non-receptor type 8
hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
NP_001180360.1
NP_036543.4
NP_057051.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p13.2

Summary This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009].
Disorder

MIM: 600716

{Diabetes, type 1, susceptibility to}, 222100 (3); {Rheumatoid

mRNA Protein Product Sequence Price Select
NM_001193431, 301171668 NP_001180360, 301171669 tyrosine-protein phosphatase non-receptor type 22 isoform 3 ORF Sequence $750.00
NM_012411, 301171661 NP_036543, 301171662 tyrosine-protein phosphatase non-receptor type 22 isoform 2 ORF Sequence $700.00
NM_015967, 301171653 NP_057051, 224586929 tyrosine-protein phosphatase non-receptor type 22 isoform 1 ORF Sequence $750.00
XM_005270738, 530362356 XP_005270795, 530362357 tyrosine-protein phosphatase non-receptor type 22 isoform X1 ORF Sequence $750.00
Homo sapiens (human)PTPN22NP_057051.3
Pan troglodytes (chimpanzee)PTPN22XP_513663.2
Macaca mulatta (Rhesus monkey)PTPN22XP_001110241.1
Canis lupus familiaris (dog)PTPN22XP_540240.3
Bos taurus (cattle)PTPN22NP_001179432.2
Mus musculus (house mouse)Ptpn22NP_033005.1
Rattus norvegicus (Norway rat)Ptpn22NP_001099930.1
Gallus gallus (chicken)PTPN22XP_001235234.1
Xenopus (Silurana) tropicalis (western clawed frog)ptpn22XP_002932177.2
Process
IDNameEvidence
GO:0006470protein dephosphorylationIDA
GO:0006470protein dephosphorylationTAS
GO:0030217T cell differentiationISS
GO:0032817regulation of natural killer cell proliferationIDA
GO:0035335peptidyl-tyrosine dephosphorylationIDA
GO:0035335peptidyl-tyrosine dephosphorylationIEA
GO:0035644phosphoanandamide dephosphorylationISS
GO:0045088regulation of innate immune responseIC
GO:0050855regulation of B cell receptor signaling pathwayNAS
GO:0050860negative regulation of T cell receptor signaling pathwayIDA
GO:0050868negative regulation of T cell activationIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmTAS
GO:0009898cytoplasmic side of plasma membraneIDA
GO:0048471perinuclear region of cytoplasmIDA
Function
IDNameEvidence
GO:0004725protein tyrosine phosphatase activityIDA
GO:0005515protein bindingIPI
GO:0017124SH3 domain bindingISS
GO:0019900kinase bindingISS
GeneCards PTPN22
UniProt B4DZW8, Q9Y2R2
Vega OTTHUMG00000011936
MIM 600716
Ensembl ENSG00000134242
HGNC 9652
HPRD 06100

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PTPN22 gene?

The PTPN22 gene provides instructions for making a protein that belongs to the PTP (protein tyrosine phosphatases) family. PTP proteins play a role in regulating a process called signal transduction. In signal transduction, the protein relays signals from outside the cell to the cell nucleus. These signals instruct the cell to grow and divide or to mature and take on specialized functions.

The PTPN22 protein is involved in signaling that helps control the activity of immune system cells called T cells. T cells identify foreign substances and defend the body against infection.

Interactant

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