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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu14496 NM_012411 Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu14911 NM_001193431 Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu21775 NM_015967 Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu33336 XM_005270738 PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu14496C NM_012411 Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant 2, mRNA. Customized vector On-demand 12-14 $329.00
OHu14911C NM_001193431 Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant 3, mRNA. Customized vector On-demand 12-14 $329.00
OHu21775C NM_015967 Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00
OHu33336C XM_005270738 PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol PTPN22
Entrez Gene ID 26191
Full Name protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms LYP, LYP1, LYP2, PEP, PTPN8
General protein information
Preferred Names
tyrosine-protein phosphatase non-receptor type 22
Names
tyrosine-protein phosphatase non-receptor type 22
lymphoid phosphatase
PEST-domain phosphatase
lymphoid-specific protein tyrosine phosphatase
protein tyrosine phosphatase, non-receptor type 8
hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
NP_001180360.1
NP_036543.4
NP_057051.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p13.2

Summary This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009].
Disorder

MIM: 600716

{Diabetes, type 1, susceptibility to}, 222100 (3); {Rheumatoid

mRNA Protein Product Sequence Price Select
NM_001193431, 301171668 NP_001180360, 301171669 tyrosine-protein phosphatase non-receptor type 22 isoform 3 ORF Sequence $750.00
NM_012411, 301171661 NP_036543, 301171662 tyrosine-protein phosphatase non-receptor type 22 isoform 2 ORF Sequence $700.00
NM_015967, 301171653 NP_057051, 224586929 tyrosine-protein phosphatase non-receptor type 22 isoform 1 ORF Sequence $750.00
XM_005270738, 530362356 XP_005270795, 530362357 tyrosine-protein phosphatase non-receptor type 22 isoform X1 ORF Sequence $750.00
Homo sapiens (human)PTPN22NP_057051.3
Pan troglodytes (chimpanzee)PTPN22XP_513663.2
Macaca mulatta (Rhesus monkey)PTPN22XP_001110241.1
Canis lupus familiaris (dog)PTPN22XP_540240.3
Bos taurus (cattle)PTPN22NP_001179432.2
Mus musculus (house mouse)Ptpn22NP_033005.1
Rattus norvegicus (Norway rat)Ptpn22NP_001099930.1
Gallus gallus (chicken)PTPN22XP_001235234.1
Xenopus (Silurana) tropicalis (western clawed frog)ptpn22XP_002932177.2
Process
IDNameEvidence
GO:0006470protein dephosphorylationIDA
GO:0006470protein dephosphorylationTAS
GO:0030217T cell differentiationISS
GO:0032817regulation of natural killer cell proliferationIDA
GO:0035335peptidyl-tyrosine dephosphorylationIDA
GO:0035335peptidyl-tyrosine dephosphorylationIEA
GO:0035644phosphoanandamide dephosphorylationISS
GO:0045088regulation of innate immune responseIC
GO:0050855regulation of B cell receptor signaling pathwayNAS
GO:0050860negative regulation of T cell receptor signaling pathwayIDA
GO:0050868negative regulation of T cell activationIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmTAS
GO:0009898cytoplasmic side of plasma membraneIDA
GO:0048471perinuclear region of cytoplasmIDA
Function
IDNameEvidence
GO:0004725protein tyrosine phosphatase activityIDA
GO:0005515protein bindingIPI
GO:0017124SH3 domain bindingISS
GO:0019900kinase bindingISS
GeneCards PTPN22
UniProt B4DZW8, Q9Y2R2
Vega OTTHUMG00000011936
MIM 600716
Ensembl ENSG00000134242
HGNC 9652
HPRD 06100

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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