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GATA3 GATA binding protein 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001002295 Homo sapiens GATA binding protein 3 (GATA3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_002051 Homo sapiens GATA binding protein 3 (GATA3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005252442 PREDICTED: Homo sapiens GATA binding protein 3 (GATA3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005252443 PREDICTED: Homo sapiens GATA binding protein 3 (GATA3), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol GATA3
Entrez Gene ID 2625
Full Name GATA binding protein 3
Synonyms HDR, HDRS
General protein information
Preferred Names
trans-acting T-cell-specific transcription factor GATA-3
Names
trans-acting T-cell-specific transcription factor GATA-3
GATA-binding factor 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10p15

Summary This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009].
Disorder

MIM: 131320

Hypoparathyroidism, sensorineural deafness, and renal dysplasia,

mRNA Protein Product Sequence Price Select
NM_001002295, 50541958 NP_001002295, 50541959 trans-acting T-cell-specific transcription factor GATA-3 isoform 1 ORF Sequence $550.00
NM_002051, 50541957 NP_002042, 4503929 trans-acting T-cell-specific transcription factor GATA-3 isoform 2 ORF Sequence $550.00
XM_005252442, 530392138 XP_005252499, 530392139 trans-acting T-cell-specific transcription factor GATA-3 isoform X1 ORF Sequence $550.00
XM_005252443, 578818388 XP_005252500, 530392141 trans-acting T-cell-specific transcription factor GATA-3 isoform X2 ORF Sequence $550.00
KEGG
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP236Adipogenesis
WP69TCR Signaling Pathway
WP706SIDS Susceptibility Pathways
Pathway Interaction Database
il27pathwayIL27-mediated signaling events
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
reg_gr_pathwayGlucocorticoid receptor regulatory network
cmyb_pathwayC-MYB transcription factor network
notch_pathwayNotch signaling pathway
Reactome
REACT_604Hemostasis
REACT_24970Factors involved in megakaryocyte development and platelet production
Homo sapiens (human)GATA3NP_002042.1
Pan troglodytes (chimpanzee)GATA3XP_507651.1
Macaca mulatta (Rhesus monkey)GATA3XP_001108337.1
Canis lupus familiaris (dog)GATA3XP_849153.1
Bos taurus (cattle)GATA3NP_001070272.1
Mus musculus (house mouse)Gata3NP_032117.1
Rattus norvegicus (Norway rat)Gata3NP_579827.1
Gallus gallus (chicken)GATA3NP_001008444.1
Danio rerio (zebrafish)gata3NP_571286.1
Xenopus (Silurana) tropicalis (western clawed frog)gata3NP_001004967.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001701in utero embryonic developmentIEA
GO:0001709cell fate determinationISS
GO:0001764neuron migrationIEA
GO:0001806type IV hypersensitivityIEA
GO:0001822kidney developmentIMP
GO:0001823mesonephros developmentISS
GO:0002088lens development in camera-type eyeIEA
GO:0002572pro-T cell differentiationIEA
GO:0003180aortic valve morphogenesisISS
GO:0003215cardiac right ventricle morphogenesisISS
GO:0003281ventricular septum developmentISS
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0006952defense responseTAS
GO:0006959humoral immune responseIEA
GO:0007165signal transductionISS
GO:0007411axon guidanceIEA
GO:0007596blood coagulationTAS
GO:0008285negative regulation of cell proliferationISS
GO:0008584male gonad developmentISS
GO:0009615response to virusIEP
GO:0009653anatomical structure morphogenesisTAS
GO:0009791post-embryonic developmentIEA
GO:0009967positive regulation of signal transductionIMP
GO:0010332response to gamma radiationIEA
GO:0010595positive regulation of endothelial cell migrationIMP
GO:0014065phosphatidylinositol 3-kinase signalingISS
GO:0030218erythrocyte differentiationIEA
GO:0031929TOR signalingISS
GO:0032689negative regulation of interferon-gamma productionIEA
GO:0032703negative regulation of interleukin-2 productionIEA
GO:0032736positive regulation of interleukin-13 productionIEA
GO:0032753positive regulation of interleukin-4 productionISS
GO:0032754positive regulation of interleukin-5 productionIEA
GO:0033600negative regulation of mammary gland epithelial cell proliferationIDA
GO:0035162embryonic hemopoiesisIEA
GO:0035457cellular response to interferon-alphaIEP
GO:0035799ureter maturationIEA
GO:0035898parathyroid hormone secretionIEA
GO:0042035regulation of cytokine biosynthetic processISS
GO:0042421norepinephrine biosynthetic processISS
GO:0042472inner ear morphogenesisIEA
GO:0042493response to drugIEA
GO:0043370regulation of CD4-positive, alpha-beta T cell differentiationIEA
GO:0043523regulation of neuron apoptotic processIEA
GO:0043583ear developmentIMP
GO:0043627response to estrogenIEP
GO:0045061thymic T cell selectionIEA
GO:0045064T-helper 2 cell differentiationIEA
GO:0045087innate immune responseIEA
GO:0045471response to ethanolIEA
GO:0045582positive regulation of T cell differentiationISS
GO:0045599negative regulation of fat cell differentiationIMP
GO:0045786negative regulation of cell cycleIMP
GO:0045892negative regulation of transcription, DNA-templatedIMP
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIMP
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS
GO:0048469cell maturationIEA
GO:0048485sympathetic nervous system developmentISS
GO:0048538thymus developmentIEA
GO:0048589developmental growthIEA
GO:0048646anatomical structure formation involved in morphogenesisISS
GO:0050728negative regulation of inflammatory responseIMP
GO:0050852T cell receptor signaling pathwayISS
GO:0051569regulation of histone H3-K4 methylationIEA
GO:0051897positive regulation of protein kinase B signalingIMP
GO:0060017parathyroid gland developmentIEA
GO:0060037pharyngeal system developmentISS
GO:0060065uterus developmentISS
GO:0060231mesenchymal to epithelial transitionIDA
GO:0060374mast cell differentiationIEA
GO:0060676ureteric bud formationISS
GO:0061085regulation of histone H3-K27 methylationIEA
GO:0061290canonical Wnt signaling pathway involved in metanephric kidney developmentISS
GO:0071353cellular response to interleukin-4IEP
GO:0071356cellular response to tumor necrosis factorIEP
GO:0071599otic vesicle developmentIEA
GO:0071773cellular response to BMP stimulusIEA
GO:0072107positive regulation of ureteric bud formationISS
GO:0072178nephric duct morphogenesisISS
GO:0072179nephric duct formationISS
GO:0072182regulation of nephron tubule epithelial cell differentiationISS
GO:0072602interleukin-4 secretionIEA
GO:0072643interferon-gamma secretionIEA
GO:0072676lymphocyte migrationIDA
GO:2000114regulation of establishment of cell polarityIEA
GO:2000146negative regulation of cell motilityIMP
GO:2000352negative regulation of endothelial cell apoptotic processIMP
GO:2000607negative regulation of cell proliferation involved in mesonephros developmentISS
GO:2000611positive regulation of thyroid hormone generationIMP
GO:2000664positive regulation of interleukin-5 secretionIDA
GO:2000667positive regulation of interleukin-13 secretionIDA
GO:2000667positive regulation of interleukin-13 secretionIMP
GO:2000679positive regulation of transcription regulatory region DNA bindingIMP
GO:2000683regulation of cellular response to X-rayIMP
GO:2000703negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formationISS
GO:2000734negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationISS
Component
IDNameEvidence
GO:0000790nuclear chromatinIDA
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
Function
IDNameEvidence
GO:0000976transcription regulatory region sequence-specific DNA bindingIDA
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEA
GO:0000987core promoter proximal region sequence-specific DNA bindingIDA
GO:0001046core promoter sequence-specific DNA bindingIDA
GO:0001071nucleic acid binding transcription factor activityIDA
GO:0001071nucleic acid binding transcription factor activityIMP
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEA
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIMP
GO:0001158enhancer sequence-specific DNA bindingIEA
GO:0003677DNA bindingTAS
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0003713transcription coactivator activityIDA
GO:0005134interleukin-2 receptor bindingIEA
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIPI
GO:0008270zinc ion bindingIEA
GO:0044212transcription regulatory region DNA bindingIDA
GO:0046983protein dimerization activityIEA
GO:0070888E-box bindingIDA
GO:0071837HMG box domain bindingIPI
GeneCards GATA3
UniProt P23771
Vega OTTHUMG00000017640
MIM 131320
Ensembl ENSG00000107485
HGNC 4172
HPRD 00572

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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