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GATA6 GATA binding protein 6 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu27933 NM_005257 Homo sapiens GATA binding protein 6 (GATA6), mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu27933 XM_005258248 PREDICTED: Homo sapiens GATA binding protein 6 (GATA6), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu27933C NM_005257 Homo sapiens GATA binding protein 6 (GATA6), mRNA. Customized vector On-demand TBD $269.00
OHu27933C XM_005258248 PREDICTED: Homo sapiens GATA binding protein 6 (GATA6), transcript variant X1, mRNA. Customized vector On-demand TBD $269.00

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Gene Symbol GATA6
Entrez Gene ID 2627
Full Name GATA binding protein 6
Synonyms
General protein information
Preferred Names
transcription factor GATA-6
Names
transcription factor GATA-6
GATA-binding factor 6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

18

18q11.1-q11.2

Summary This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012].
Disorder

MIM: 601656

mRNA Protein Product Sequence Price Select
NM_005257, 625180325 NP_005248, 40288197 transcription factor GATA-6 ORF Sequence $700.00
XM_005258248, 578832441 XP_005258305, 530413753 transcription factor GATA-6 isoform X1 ORF Sequence $700.00
WikiPathways
WP1591Heart Development
Pathway Interaction Database
hes_heypathwayNotch-mediated HES/HEY network
Reactome
REACT_604Hemostasis
REACT_24970Factors involved in megakaryocyte development and platelet production
Homo sapiens (human)GATA6NP_005248.2
Pan troglodytes (chimpanzee)GATA6XP_003954430.1
Macaca mulatta (Rhesus monkey)GATA6XP_002800933.1
Canis lupus familiaris (dog)GATA6XP_005623196.1
Mus musculus (house mouse)Gata6NP_034388.2
Rattus norvegicus (Norway rat)Gata6NP_062058.1
Danio rerio (zebrafish)gata6NP_571632.1
Xenopus (Silurana) tropicalis (western clawed frog)gata6NP_989422.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0001701in utero embryonic developmentIEA
GO:0001889liver developmentIEA
GO:0003148outflow tract septum morphogenesisIMP
GO:0003309type B pancreatic cell differentiationIEA
GO:0003310pancreatic A cell differentiationIEA
GO:0006366transcription from RNA polymerase II promoterIDA
GO:0006644phospholipid metabolic processIEA
GO:0007493endodermal cell fate determinationIEA
GO:0007596blood coagulationTAS
GO:0008584male gonad developmentIEP
GO:0014898cardiac muscle hypertrophy in response to stressIEA
GO:0032911negative regulation of transforming growth factor beta1 productionIMP
GO:0032912negative regulation of transforming growth factor beta2 productionIMP
GO:0035239tube morphogenesisIEA
GO:0042493response to drugIMP
GO:0043066negative regulation of apoptotic processIMP
GO:0043627response to estrogenIEA
GO:0045766positive regulation of angiogenesisIDA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0048645organ formationIEA
GO:0051145smooth muscle cell differentiationIMP
GO:0051891positive regulation of cardioblast differentiationIEA
GO:0055007cardiac muscle cell differentiationIEA
GO:0060045positive regulation of cardiac muscle cell proliferationIEA
GO:0060430lung saccule developmentIEA
GO:0060486Clara cell differentiationIEA
GO:0060510Type II pneumocyte differentiationIEA
GO:0060575intestinal epithelial cell differentiationIDA
GO:0060947cardiac vascular smooth muscle cell differentiationIMP
GO:0070848response to growth factorIDA
GO:0071158positive regulation of cell cycle arrestIDA
GO:0071371cellular response to gonadotropin stimulusIEA
GO:0071456cellular response to hypoxiaIDA
GO:0071773cellular response to BMP stimulusIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005667transcription factor complexIEA
Function
IDNameEvidence
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEA
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activityIMP
GO:0001103RNA polymerase II repressing transcription factor bindingIEA
GO:0003682chromatin bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEA
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIPI
GO:0008270zinc ion bindingIEA
GO:0019901protein kinase bindingIPI
GO:0044212transcription regulatory region DNA bindingIDA
GeneCards GATA6
UniProt Q92908
Vega OTTHUMG00000131767
MIM 601656
Ensembl ENSG00000141448
HGNC 4174
HPRD 09043

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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