Search Tips

  • THAT   AND
  • THAT   AND


GCK glucokinase (hexokinase 4) [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_000162 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 1, mRNA. Full Length $794.89
ORF Sequence $405.42
NM_033507 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 2, mRNA. Full Length $708.18
ORF Sequence $406.29
NM_033508 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 3, mRNA. Full Length $744.14
ORF Sequence $404.55


Gene Symbol GCK
Entrez Gene ID 2645
Full Name glucokinase (hexokinase 4)
Synonyms FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p15.3-p15.1
Summary Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq].
Disorder

MIM: 138079

MODY, type II, 125851 (3); Diabetes mellitus, noninsulin-dependent,
mRNA NM_000162, 167621407
Protein NP_000153, 4503951
Product glucokinase isoform 1
RefSeq Status REVIEWED
mRNA NM_033507, 15967158
Protein NP_277042, 15967159
Product glucokinase isoform 2
RefSeq Status REVIEWED
mRNA NM_033508, 15967160
Protein NP_277043, 15967161
Product glucokinase isoform 3
RefSeq Status REVIEWED
KEGG
hsa04950Maturity onset diabetes of the young
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
hsa00010Glycolysis / Gluconeogenesis
hsa04930Type II diabetes mellitus
hsa00524Butirosin and neomycin biosynthesis
hsa00052Galactose metabolism
hsa04910Insulin signaling pathway
hsa00500Starch and sucrose metabolism
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
hif1_tfpathwayHIF-1-alpha transcription factor network
WikiPathways
WP382MAPK signaling pathway
WP534Glycolysis and Gluconeogenesis
BIOCYC
META_PWY-5661GDP-glucose biosynthesis
Reactome
REACT_474Metabolism of carbohydrates
REACT_9441Hexose transport
REACT_6804Regulation of Glucokinase by Glucokinase Regulatory Protein
REACT_13698Regulation of beta-cell development
REACT_19118SLC-mediated transmembrane transport
REACT_212Glucose transport
REACT_13819Regulation of gene expression in beta cells
REACT_15518Transmembrane transport of small molecules
Homo sapiens (human)GCKNP_000153.1
Pan troglodytes (chimpanzee)GCKXP_001143661.1
Bos taurus (cattle)GCKNP_001095772.1
Mus musculus (house mouse)GckNP_034422.2
Rattus norvegicus (Norway rat)GckNP_036697.1
Danio rerio (zebrafish)gckNP_001038850.1
Drosophila melanogaster (fruit fly)Hex-CNP_524674.1
Arabidopsis thaliana (thale cress)HXK3NP_175220.2
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0006110regulation of glycolysisNAS
GO:0008645hexose transportTAS
GO:0010827regulation of glucose transportTAS
GO:0015758glucose transportTAS
GO:0031018endocrine pancreas developmentTAS
GO:0032024positive regulation of insulin secretionIMP
GO:0032869cellular response to insulin stimulusISS
GO:0042593glucose homeostasisIMP
GO:0044320cellular response to leptin stimulusISS
GO:0045721negative regulation of gluconeogenesisIMP
GO:0045725positive regulation of glycogen biosynthetic processIMP
GO:0050796regulation of insulin secretionIMP
GO:0051156glucose 6-phosphate metabolic processIDA
GO:0051156glucose 6-phosphate metabolic processTAS
GO:0051594detection of glucoseIMP
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005654nucleoplasmEXP
GO:0005829cytosolEXP
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0004340glucokinase activityIDA
GO:0004340glucokinase activityTAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0005536glucose bindingIDA
GO:0016301kinase activityIEA
GO:0016740transferase activityIEA
GeneCards GCK
PDB 3FGU, 3A0I, 1GLK, 3IDH, 1V4S, 3F9M, 3ID8, 3IMX, 3GOI, 3H1V, 3FR0, 1V4T
UniProt Q53Y25, P35557
MIM 138079
Ensembl ENSG00000106633
HGNC 4195
HPRD 00680

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Secured Online Quotation
Email: gene@genscript.com
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262 1-732-885-5878