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GCK glucokinase (hexokinase 4) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17606 NM_033508 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17640 NM_033507 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18369 NM_000162 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17606C NM_033508 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu17640C NM_033507 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu18369C NM_000162 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol GCK
Entrez Gene ID 2645
Full Name glucokinase (hexokinase 4)
Synonyms FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
General protein information
Preferred Names
glucokinase
Names
glucokinase
HK IV
hexokinase-4
hexokinase-D
hexokinase type IV
hexokinase D, pancreatic isozyme
ATP:D-hexose 6-phosphotransferase
NP_000153.1
NP_277042.1
NP_277043.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p15.3-p15.1

Summary Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009].
Disorder

MIM: 138079

MODY, type II, 125851 (3); Diabetes mellitus, noninsulin-dependent,

mRNA Protein Product Sequence Price Select
NM_000162, 167621407 NP_000153, 4503951 glucokinase isoform 1 ORF Sequence $360.00
NM_033507, 15967158 NP_277042, 15967159 glucokinase isoform 2 ORF Sequence $550.00
NM_033508, 15967160 NP_277043, 15967161 glucokinase isoform 3 ORF Sequence $550.00
KEGG
hsa00052Galactose metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00500Starch and sucrose metabolism
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus
hsa04950Maturity onset diabetes of the young
hsa00524Butirosin and neomycin biosynthesis
hsa_M00001Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa_M00549Nucleotide sugar biosynthesis, glucose => UDP-glucose
hsa04917Prolactin signaling pathway
hsa01200Carbon metabolism
hsa04911Insulin secretion
WikiPathways
WP382MAPK signaling pathway
WP534Glycolysis and Gluconeogenesis
WP706SIDS Susceptibility Pathways
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
hif1_tfpathwayHIF-1-alpha transcription factor network
BIOCYC
META_ANAEROFRUCAT-PWYhomolactic fermentation
HUMAN_PWY-5661GDP-glucose biosynthesis
HUMAN_GLUCOSE1PMETAB-PWYglucose and glucose-1-phosphate degradation
HUMAN_PWY0-1182trehalose degradation II (trehalase)
HUMAN_PWY-5514UDP-N-acetyl-D-galactosamine biosynthesis II
META_PWY66-400glycolysis VI (metazoan)
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_212Glucose transport
REACT_6804Regulation of Glucokinase by Glucokinase Regulatory Protein
REACT_9441Hexose transport
REACT_474Metabolism of carbohydrates
REACT_13698Regulation of beta-cell development
REACT_15518Transmembrane transport of small molecules
REACT_13819Regulation of gene expression in beta cells
REACT_111217Metabolism
REACT_111045Developmental Biology
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)GCKNP_000153.1
Pan troglodytes (chimpanzee)GCKXP_001143302.1
Macaca mulatta (Rhesus monkey)GCKXP_001093035.2
Bos taurus (cattle)GCKNP_001095772.1
Mus musculus (house mouse)GckNP_034422.2
Rattus norvegicus (Norway rat)GckNP_036697.1
Gallus gallus (chicken)GCKXP_427930.4
Danio rerio (zebrafish)gckNP_001038850.2
Xenopus (Silurana) tropicalis (western clawed frog)gckNP_001096321.1
Process
IDNameEvidence
GO:0001678cellular glucose homeostasisIBA
GO:0005975carbohydrate metabolic processTAS
GO:0005978glycogen biosynthetic processIEA
GO:0006003fructose 2,6-bisphosphate metabolic processIEA
GO:0006006glucose metabolic processIEA
GO:0006096glycolytic processIEA
GO:0006110regulation of glycolytic processNAS
GO:0006739NADP metabolic processIEA
GO:0007204positive regulation of cytosolic calcium ion concentrationIEA
GO:0008645hexose transportTAS
GO:0010827regulation of glucose transportTAS
GO:0015758glucose transportTAS
GO:0019932second-messenger-mediated signalingIEA
GO:0031018endocrine pancreas developmentTAS
GO:0032024positive regulation of insulin secretionIMP
GO:0032811negative regulation of epinephrine secretionIEA
GO:0032869cellular response to insulin stimulusISS
GO:0042149cellular response to glucose starvationIEA
GO:0042327positive regulation of phosphorylationIEA
GO:0042593glucose homeostasisIMP
GO:0043266regulation of potassium ion transportIEA
GO:0044281small molecule metabolic processTAS
GO:0044320cellular response to leptin stimulusISS
GO:0045721negative regulation of gluconeogenesisIMP
GO:0045725positive regulation of glycogen biosynthetic processIMP
GO:0045821positive regulation of glycolytic processIEA
GO:0046835carbohydrate phosphorylationIEA
GO:0050796regulation of insulin secretionIMP
GO:0051156glucose 6-phosphate metabolic processIEA
GO:0051594detection of glucoseIMP
GO:0055085transmembrane transportTAS
GO:0070509calcium ion importIEA
Component
IDNameEvidence
GO:0005654nucleoplasmTAS
GO:0005739mitochondrionIEA
GO:0005829cytosolTAS
GO:0005938cell cortexIEA
GO:0030141secretory granuleIEA
Function
IDNameEvidence
GO:0000287magnesium ion bindingIEA
GO:0004340glucokinase activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0005536glucose bindingIDA
GO:0008865fructokinase activityIBA
GO:0019158mannokinase activityIBA
GO:0019903protein phosphatase bindingIEA
GO:0043531ADP bindingIEA
GeneCards GCK
UniProt Q53Y25, P35557
Vega OTTHUMG00000022903
MIM 138079
Ensembl ENSG00000106633
HGNC 4195
HPRD 00680

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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