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GCK glucokinase (hexokinase 4) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000162 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 1, mRNA. ORF Sequence $405.42
Peptide Services
Antibody Services
Protein Services
NM_033507 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 2, mRNA. ORF Sequence $406.29
Peptide Services
Antibody Services
Protein Services
NM_033508 Homo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 3, mRNA. ORF Sequence $404.55
Peptide Services
Antibody Services
Protein Services


Gene Symbol GCK
Entrez Gene ID 2645
Full Name glucokinase (hexokinase 4)
Synonyms FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p15.3-p15.1

Summary Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009].
Disorder

MIM: 138079

MODY, type II, 125851 (3); Diabetes mellitus, noninsulin-dependent,

mRNA Protein Product Sequence Price Select
NM_000162, 167621407 NP_000153, 4503951 glucokinase isoform 1 Full Length $794.89
ORF Sequence $405.42
NM_033507, 15967158 NP_277042, 15967159 glucokinase isoform 2 Full Length $708.18
ORF Sequence $406.29
NM_033508, 15967160 NP_277043, 15967161 glucokinase isoform 3 Full Length $744.14
ORF Sequence $404.55
KEGG
hsa00500Starch and sucrose metabolism
hsa04910Insulin signaling pathway
hsa00052Galactose metabolism
hsa_M00001Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa04950Maturity onset diabetes of the young
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa04930Type II diabetes mellitus
hsa00524Butirosin and neomycin biosynthesis
hsa_M00549Nucleotide sugar biosynthesis, glucose => UDP-glucose
WikiPathways
WP534Glycolysis and Gluconeogenesis
WP382MAPK signaling pathway
WP706SIDS Susceptibility Pathways
Pathway Interaction Database
hif1_tfpathwayHIF-1-alpha transcription factor network
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
BIOCYC
HUMAN_GLUCOSE1PMETAB-PWYglucose and glucose-1-phosphate degradation
HUMAN_PWY0-1182trehalose degradation II (trehalase)
META_PWY-5661GDP-glucose biosynthesis
HUMAN_PWY-5514UDP-N-acetyl-D-galactosamine biosynthesis II
HUMAN_PWY-5661GDP-glucose biosynthesis
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_13819Regulation of gene expression in beta cells
REACT_474Metabolism of carbohydrates
REACT_6804Regulation of Glucokinase by Glucokinase Regulatory Protein
REACT_111045Developmental Biology
REACT_19118SLC-mediated transmembrane transport
REACT_111217Metabolism
REACT_13698Regulation of beta-cell development
REACT_9441Hexose transport
REACT_212Glucose transport
Homo sapiens (human)GCKNP_000153.1
Pan troglodytes (chimpanzee)GCKXP_001143302.1
Macaca mulatta (Rhesus monkey)GCKXP_001093035.2
Bos taurus (cattle)GCKNP_001095772.1
Mus musculus (house mouse)GckNP_034422.2
Rattus norvegicus (Norway rat)GckNP_036697.1
Gallus gallus (chicken)GCKXP_427930.3
Danio rerio (zebrafish)gckNP_001038850.2
Drosophila melanogaster (fruit fly)Hex-CNP_524674.1
Arabidopsis thaliana (thale cress)HXK3NP_175220.2
GeneCards GCK
PDB 3QIC, 4DCH, 1GLK, 3VEY, 3IMX, 3GOI, 3H1V, 1V4T, 3FGU, 3A0I, 4DHY, 1V4S, 3IDH, 3F9M, 3ID8, 3VF6, 3FR0, 3S41, 3VEV
UniProt Q53Y25, P35557
MIM 138079
Ensembl ENSG00000106633
HGNC 4195
HPRD 00680

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
glucokinase
Names
glucokinase
HK IV
hexokinase-4
hexokinase-D
hexokinase type IV
hexokinase D, pancreatic isozyme
ATP:D-hexose 6-phosphotransferase
NP_000153.1
NP_277042.1
NP_277043.1

Interactant

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