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LHX6 LIM homeobox 6 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_014368 Homo sapiens LIM homeobox 6 (LHX6), transcript variant 1, mRNA. Full Length $1181.95
ORF Sequence $341.91
NM_199160 Homo sapiens LIM homeobox 6 (LHX6), transcript variant 2, mRNA. Full Length $1145.55
ORF Sequence $328.86


Gene Symbol LHX6
Entrez Gene ID 26468
Full Name LIM homeobox 6
Synonyms LHX6.1, MGC119542, MGC119544, MGC119545
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q33.2
Summary This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq].
Disorder

MIM: 608215
mRNA NM_014368, 134284358
Protein NP_055183, 134284359
Product LIM/homeobox protein Lhx6 isoform 1
RefSeq Status REVIEWED
mRNA NM_199160, 134284360
Protein NP_954629, 134284361
Product LIM/homeobox protein Lhx6 isoform 2
RefSeq Status REVIEWED
Homo sapiens (human)LHX6NP_055183.2
Pan troglodytes (chimpanzee)LHX6XP_001135172.1
Canis lupus familiaris (dog)LHX6XP_548475.2
Bos taurus (cattle)LHX6XP_615356.4
Mus musculus (house mouse)Lhx6NP_032526.2
Rattus norvegicus (Norway rat)Lhx6XP_231175.4
Gallus gallus (chicken)LHX6XP_001235421.1
Danio rerio (zebrafish)lhx6NP_001004015.1
Process
IDNameEvidence
GO:0006351transcription, DNA-dependentNAS
GO:0006355regulation of transcription, DNA-dependentIEA
GO:0007275multicellular organismal developmentIEA
GO:0007399nervous system developmentIEA
GO:0021799cerebral cortex radially oriented cell migrationISS
GO:0021800cerebral cortex tangential migrationISS
GO:0021853cerebral cortex GABAergic interneuron migrationISS
GO:0021877forebrain neuron fate commitmentIEA
GO:0021884forebrain neuron developmentIEA
GO:0021895cerebral cortex neuron differentiationIEA
GO:0030154cell differentiationIEA
GO:0048469cell maturationISS
Component
IDNameEvidence
GO:0005634nucleusIDA
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityNAS
GO:0008270zinc ion bindingIEA
GO:0043565sequence-specific DNA bindingIEA
GO:0046872metal ion bindingIEA
GeneCards LHX6
UniProt Q9UPM6
MIM 608215
Ensembl ENSG00000106852
HGNC 21735
HPRD 10498

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