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HEYL hes-related family bHLH transcription factor with YRPW motif-like [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu06538 NM_014571 Homo sapiens hes-related family bHLH transcription factor with YRPW motif-like (HEYL), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu33344 XM_005270745 PREDICTED: Homo sapiens hes-related family bHLH transcription factor with YRPW motif-like (HEYL), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu06538C NM_014571 Homo sapiens hes-related family bHLH transcription factor with YRPW motif-like (HEYL), mRNA. Customized vector In-stock 5-7 $149.00
OHu33344C XM_005270745 PREDICTED: Homo sapiens hes-related family bHLH transcription factor with YRPW motif-like (HEYL), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol HEYL
Entrez Gene ID 26508
Full Name hes-related family bHLH transcription factor with YRPW motif-like
Synonyms HESR3, HEY3, HRT3, bHLHb33
General protein information
Preferred Names
hairy/enhancer-of-split related with YRPW motif-like protein
Names
hairy/enhancer-of-split related with YRPW motif-like protein
HRT-3
hHRT3
hHeyL
HEY-like protein
hairy-related transcription factor 3
class B basic helix-loop-helix protein 33
hairy/enhancer-of-split related with YRPW motif 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p34.3

Summary This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Disorder

MIM: 609034

mRNA Protein Product Sequence Price Select
NM_014571, 105990530 NP_055386, 7657154 hairy/enhancer-of-split related with YRPW motif-like protein ORF Sequence $269.00
XM_005270745, 530362370 XP_005270802, 530362371 hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 ORF Sequence $300.00
Reactome
REACT_299Signaling by NOTCH
REACT_111102Signal Transduction
REACT_116125Disease
REACT_118859Signaling by NOTCH1
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
Homo sapiens (human)HEYLNP_055386.1
Pan troglodytes (chimpanzee)HEYLXP_001171234.1
Macaca mulatta (Rhesus monkey)LOC716117XP_001113370.1
Canis lupus familiaris (dog)HEYLXP_849702.1
Bos taurus (cattle)HEYLNP_001019736.2
Mus musculus (house mouse)HeylNP_038933.2
Rattus norvegicus (Norway rat)HeylNP_001101447.1
Gallus gallus (chicken)HEYLXP_001234406.2
Danio rerio (zebrafish)heylNP_859425.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0003151outflow tract morphogenesisISS
GO:0003181atrioventricular valve morphogenesisISS
GO:0003184pulmonary valve morphogenesisISS
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formationISS
GO:0003203endocardial cushion morphogenesisISS
GO:0003208cardiac ventricle morphogenesisISS
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0006366transcription from RNA polymerase II promoterISS
GO:0007219Notch signaling pathwayIDA
GO:0007219Notch signaling pathwayTAS
GO:0014031mesenchymal cell developmentISS
GO:0032835glomerulus developmentIEA
GO:0035914skeletal muscle cell differentiationIEA
GO:0045666positive regulation of neuron differentiationISS
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0060317cardiac epithelial to mesenchymal transitionISS
GO:0060412ventricular septum morphogenesisISS
GO:0060766negative regulation of androgen receptor signaling pathwayIDA
GO:0071773cellular response to BMP stimulusIEA
GO:0072014proximal tubule developmentIEA
GO:2000824negative regulation of androgen receptor activityIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005737cytoplasmISS
Function
IDNameEvidence
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEA
GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activityISS
GO:0000988protein binding transcription factor activityIDA
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEA
GO:0001106RNA polymerase II transcription corepressor activityIEA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003714transcription corepressor activityIDA
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingNAS
GO:0035939microsatellite bindingIDA
GO:0042803protein homodimerization activityIEA
GO:0046982protein heterodimerization activityIDA
GO:0050683AF-1 domain bindingIPI
GeneCards HEYL
UniProt Q9NQ87, F5H3V9
Vega OTTHUMG00000000458
MIM 609034
Ensembl ENSG00000163909
HGNC 4882
HPRD 16419

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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