HEYL hairy/enhancer-of-split related with YRPW motif-like [Homo sapiens (human)]
| Gene Symbol | HEYL |
| Entrez Gene ID | 26508 |
| Full Name | hairy/enhancer-of-split related with YRPW motif-like |
| Synonyms | HEY3, HRT3, MGC12623, bHLHb33 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p34.3 |
| Summary | This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 609034 |
| mRNA | NM_014571, 105990530 |
| Protein | NP_055386, 7657154 |
| Product | hairy/enhancer-of-split related with YRPW motif-like protein |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | HEYL | NP_055386.1 |
| Pan troglodytes (chimpanzee) | HEYL | XP_001171234.1 |
| Canis lupus familiaris (dog) | HEYL | XP_849702.1 |
| Bos taurus (cattle) | HEYL | NP_001019736.1 |
| Mus musculus (house mouse) | Heyl | NP_038933.2 |
| Rattus norvegicus (Norway rat) | Heyl | XP_233495.1 |
| Gallus gallus (chicken) | HEYL | XP_001234406.1 |
| Danio rerio (zebrafish) | heyl | NP_859425.1 |
| ID | Name | Evidence |
| GO:0006351 | transcription, DNA-dependent | NAS |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
| GO:0007219 | Notch signaling pathway | IEA |
| GO:0007275 | multicellular organismal development | IEA |
| GO:0007399 | nervous system development | TAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
Function
| ID | Name | Evidence |
| GO:0003677 | DNA binding | IEA |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | NAS |
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