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GH1 growth hormone 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25686 NM_022559 Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu25687 NM_022560 Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu27940 NM_000515 Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu50278 XM_005257218 PREDICTED: Homo sapiens growth hormone 1 (GH1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu50279 XM_005257219 PREDICTED: Homo sapiens growth hormone 1 (GH1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu25686C NM_022559 Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu25687C NM_022560 Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00
OHu27940C NM_000515 Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu50278C XM_005257218 PREDICTED: Homo sapiens growth hormone 1 (GH1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu50279C XM_005257219 PREDICTED: Homo sapiens growth hormone 1 (GH1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol GH1
Entrez Gene ID 2688
Full Name growth hormone 1
Synonyms GH, GH-N, GHN, IGHD1B, hGH-N
General protein information
Preferred Names
somatotropin
Names
somatotropin
pituitary growth hormone
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q24.2

Summary The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008].
Disorder

MIM: 139250

Growth hormone deficiency, isolated, type IA, 262400 (3); Growth

mRNA Protein Product Sequence Price Select
NM_000515, 636576917 NP_000506, 13027812 somatotropin isoform 1 precursor ORF Sequence $159.00
NM_022559, 636576918 NP_072053, 13027814 somatotropin isoform 2 precursor ORF Sequence $159.00
NM_022560, 636576919 NP_072054, 13027816 somatotropin isoform 3 precursor ORF Sequence $159.00
XM_005257218, 578830714 XP_005257275, 530411916 somatotropin isoform X1 ORF Sequence $250.00
XM_005257219, 578830715 XP_005257276, 530411918 somatotropin isoform X2 ORF Sequence $250.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04151PI3K-Akt signaling pathway
WikiPathways
WP474Endochondral Ossification
WP236Adipogenesis
Reactome
REACT_19189Synthesis, secretion, and deacylation of Ghrelin
REACT_17015Metabolism of proteins
REACT_6900Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_111102Signal Transduction
REACT_111133Growth hormone receptor signaling
REACT_115596Signaling by ERBB4
REACT_115697Prolactin receptor signaling
REACT_116022Nuclear signaling by ERBB4
REACT_160078Peptide hormone metabolism
Homo sapiens (human)GH1NP_000506.2
Pan troglodytes (chimpanzee)GH1NP_001184093.1
Macaca mulatta (Rhesus monkey)GH1NP_001036203.1
Process
IDNameEvidence
GO:0002092positive regulation of receptor internalizationIDA
GO:0007259JAK-STAT cascadeIDA
GO:0010535positive regulation of activation of JAK2 kinase activityIDA
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIDA
GO:0015758glucose transportIDA
GO:0032355response to estradiolIDA
GO:0040018positive regulation of multicellular organism growthIDA
GO:0040018positive regulation of multicellular organism growthIMP
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIDA
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIDA
GO:0043406positive regulation of MAP kinase activityTAS
GO:0043568positive regulation of insulin-like growth factor receptor signaling pathwayIDA
GO:0046427positive regulation of JAK-STAT cascadeIDA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA
GO:0060396growth hormone receptor signaling pathwayIDA
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTAS
GO:0070977bone maturationIDA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
Function
IDNameEvidence
GO:0005131growth hormone receptor bindingIDA
GO:0005131growth hormone receptor bindingIPI
GO:0005148prolactin receptor bindingIPI
GO:0005179hormone activityIEA
GO:0005515protein bindingIPI
GO:0008083growth factor activityIPI
GO:0046872metal ion bindingIEA
GeneCards GH1
UniProt B1A4H0, B1A4G9, B1A4G6, P01241, B1A4G7
Vega OTTHUMG00000172293
MIM 139250
Ensembl ENSG00000259384
HGNC 4261
HPRD 00751

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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