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GHRHR growth hormone releasing hormone receptor [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18044 NM_000823 Homo sapiens growth hormone releasing hormone receptor (GHRHR), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu18044C NM_000823 Homo sapiens growth hormone releasing hormone receptor (GHRHR), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol GHRHR
Entrez Gene ID 2692
Full Name growth hormone releasing hormone receptor
Synonyms GHRFR, GRFR, IGHD1B
General protein information
Preferred Names
growth hormone-releasing hormone receptor
Names
growth hormone-releasing hormone receptor
GRF receptor
GHRH receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p14

Summary This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010].
Disorder

MIM: 139191

Growth hormone deficiency, isolated, type IB, 612781 (3)

mRNA Protein Product Sequence Price Select
NM_000823, 297307106 NP_000814, 58530851 growth hormone-releasing hormone receptor precursor ORF Sequence $360.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
WikiPathways
WP117GPCRs, Other
WP334GPCRs, Class B Secretin-like
Reactome
REACT_19184GPCR downstream signaling
REACT_19327G alpha (s) signalling events
REACT_14797Signaling by GPCR
REACT_18372Class B/2 (Secretin family receptors)
REACT_18377Glucagon-type ligand receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
Homo sapiens (human)GHRHRNP_000814.2
Pan troglodytes (chimpanzee)GHRHRXP_519027.3
Canis lupus familiaris (dog)GHRHRXP_539502.3
Bos taurus (cattle)GHRHRNP_851363.1
Mus musculus (house mouse)GhrhrNP_001003685.2
Rattus norvegicus (Norway rat)GhrhrNP_036982.1
Gallus gallus (chicken)GHRHRNP_001032923.1
Danio rerio (zebrafish)ghrhrlNP_001075951.1
Process
IDNameEvidence
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathwayIDA
GO:0007190activation of adenylate cyclase activityIEA
GO:0007595lactationIEA
GO:0008284positive regulation of cell proliferationIDA
GO:0008340determination of adult lifespanIEA
GO:0019933cAMP-mediated signalingIMP
GO:0030104water homeostasisIEA
GO:0030252growth hormone secretionIEA
GO:0030819positive regulation of cAMP biosynthetic processIDA
GO:0032868response to insulinIMP
GO:0032869cellular response to insulin stimulusIEA
GO:0033143regulation of intracellular steroid hormone receptor signaling pathwayIEA
GO:0040018positive regulation of multicellular organism growthIMP
GO:0042445hormone metabolic processIEA
GO:0043568positive regulation of insulin-like growth factor receptor signaling pathwayNAS
GO:0043627response to estrogenIDA
GO:0048469cell maturationIEA
GO:0048609multicellular organismal reproductive processNAS
GO:0051246regulation of protein metabolic processIEA
GO:0051384response to glucocorticoidIDA
GO:0060124positive regulation of growth hormone secretionNAS
GO:0060133somatotropin secreting cell developmentIEA
Component
IDNameEvidence
GO:0005637nuclear inner membraneIDA
GO:0005640nuclear outer membraneIDA
GO:0005737cytoplasmIDA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0009986cell surfaceIDA
GO:0016021integral component of membraneIDA
GO:0016363nuclear matrixIDA
GO:0030141secretory granuleIDA
Function
IDNameEvidence
GO:0004930G-protein coupled receptor activityIC
GO:0005515protein bindingIPI
GO:0016520growth hormone-releasing hormone receptor activityIMP
GO:0017046peptide hormone bindingIPI
GO:0019838growth factor bindingIPI
GeneCards GHRHR
PDB 2XDG
UniProt Q02643
Vega OTTHUMG00000152801
MIM 139191
Ensembl ENSG00000106128
HGNC 4266
HPRD 00748

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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