• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001001485 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001001486 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001001487 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001199179 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001199180 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001199181 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001199182 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001199183 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001199184 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 10, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001199185 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 11, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_014382 Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005247354 PREDICTED: Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005247355 PREDICTED: Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005247356 PREDICTED: Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005247357 PREDICTED: Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005247358 PREDICTED: Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005247359 PREDICTED: Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006713585 PREDICTED: Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $899.00 20

*Business Day

Related Services

Gene Symbol ATP2C1
Entrez Gene ID 27032
Full Name ATPase, Ca++ transporting, type 2C, member 1
Synonyms ATP2C1A, BCPM, HHD, PMR1, SPCA1, hSPCA1
General protein information
Preferred Names
calcium-transporting ATPase type 2C member 1
Names
calcium-transporting ATPase type 2C member 1
HUSSY-28
ATPase 2C1
ATPase, Ca(2+)-sequestering
ATP-dependent Ca(2+) pump PMR1
secretory pathway Ca2+/Mn2+ ATPase 1
NP_001001485.1
NP_001001486.1
NP_001001487.1
NP_001186108.1
NP_001186109.1
NP_001186110.1
NP_001186111.1
NP_001186112.1
NP_001186113.1
NP_001186114.1
NP_055197.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q22.1

Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
Disorder

MIM: 604384

Hailey-Hailey disease, 169600 (3)

mRNA Protein Product Sequence Price Select
NM_001001485, 312836760 NP_001001485, 48762687 calcium-transporting ATPase type 2C member 1 isoform 1c ORF Sequence $750.00
NM_001001486, 48762688 NP_001001486, 48762689 calcium-transporting ATPase type 2C member 1 isoform 1d ORF Sequence $750.00
NM_001001487, 48762690 NP_001001487, 48762691 calcium-transporting ATPase type 2C member 1 isoform 1b ORF Sequence $750.00
NM_001199179, 312836762 NP_001186108, 312836763 calcium-transporting ATPase type 2C member 1 isoform 1a ORF Sequence $750.00
NM_001199180, 312836764 NP_001186109, 312836765 calcium-transporting ATPase type 2C member 1 isoform 2a ORF Sequence $750.00
NM_001199181, 312836766 NP_001186110, 312836767 calcium-transporting ATPase type 2C member 1 isoform 2b ORF Sequence $750.00
NM_001199182, 312836768 NP_001186111, 312836769 calcium-transporting ATPase type 2C member 1 isoform 2c ORF Sequence $750.00
NM_001199183, 312836770 NP_001186112, 312836771 calcium-transporting ATPase type 2C member 1 isoform 1e ORF Sequence $750.00
NM_001199184, 312836772 NP_001186113, 312836773 calcium-transporting ATPase type 2C member 1 isoform 1f ORF Sequence $750.00
NM_001199185, 312836774 NP_001186114, 312836775 calcium-transporting ATPase type 2C member 1 isoform 1c ORF Sequence $750.00
NM_014382, 312836761 NP_055197, 48762685 calcium-transporting ATPase type 2C member 1 isoform 1a ORF Sequence $750.00
XM_005247354, 530374409 XP_005247411, 530374410 calcium-transporting ATPase type 2C member 1 isoform X1 ORF Sequence $750.00
XM_005247355, 530374411 XP_005247412, 530374412 calcium-transporting ATPase type 2C member 1 isoform X2 ORF Sequence $750.00
XM_005247356, 530374413 XP_005247413, 530374414 calcium-transporting ATPase type 2C member 1 isoform X3 ORF Sequence $750.00
XM_005247357, 530374415 XP_005247414, 530374416 calcium-transporting ATPase type 2C member 1 isoform X4 ORF Sequence $750.00
XM_005247358, 530374417 XP_005247415, 530374418 calcium-transporting ATPase type 2C member 1 isoform X5 ORF Sequence $750.00
XM_005247359, 530374419 XP_005247416, 530374420 calcium-transporting ATPase type 2C member 1 isoform X6 ORF Sequence $750.00
XM_006713585, 578807268 XP_006713648, 578807269 calcium-transporting ATPase type 2C member 1 isoform X7 ORF Sequence $750.00
BIOCYC
HUMAN_PWY-6166calcium transport I
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_25149Ion transport by P-type ATPases
REACT_25300Ion channel transport
Homo sapiens (human)ATP2C1NP_001186110.1
Pan troglodytes (chimpanzee)ATP2C1XP_001146246.2
Macaca mulatta (Rhesus monkey)ATP2C1XP_002803047.1
Canis lupus familiaris (dog)ATP2C1XP_005634472.1
Bos taurus (cattle)ATP2C1NP_786979.1
Mus musculus (house mouse)Atp2c1NP_001240760.1
Rattus norvegicus (Norway rat)Atp2c1NP_571982.2
Gallus gallus (chicken)ATP2C1XP_426010.4
Danio rerio (zebrafish)atp2c1XP_003200287.2
Drosophila melanogaster (fruit fly)SPoCkNP_730742.1
Caenorhabditis eleganspmr-1NP_001021862.1
Xenopus (Silurana) tropicalis (western clawed frog)atp2c1XP_002937789.2
Process
IDNameEvidence
GO:0006816calcium ion transportIDA
GO:0006816calcium ion transportIMP
GO:0006828manganese ion transportIDA
GO:0006874cellular calcium ion homeostasisIDA
GO:0006874cellular calcium ion homeostasisIMP
GO:0007165signal transductionIMP
GO:0008152metabolic processIEA
GO:0008544epidermis developmentIMP
GO:0016339calcium-dependent cell-cell adhesionIMP
GO:0030026cellular manganese ion homeostasisIDA
GO:0031532actin cytoskeleton reorganizationIMP
GO:0032468Golgi calcium ion homeostasisIMP
GO:0032472Golgi calcium ion transportIMP
GO:0034220ion transmembrane transportTAS
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIMP
GO:0055085transmembrane transportTAS
GO:0070588calcium ion transmembrane transportIDA
GO:0070588calcium ion transmembrane transportIEA
GO:0070588calcium ion transmembrane transportIMP
GO:0071421manganese ion transmembrane transportIDA
Component
IDNameEvidence
GO:0000139Golgi membraneIDA
GO:0000139Golgi membraneTAS
GO:0005794Golgi apparatusIDA
GO:0005802trans-Golgi networkIDA
GO:0016020membraneIDA
GO:0016021integral component of membraneNAS
Function
IDNameEvidence
GO:0004871signal transducer activityIMP
GO:0005388calcium-transporting ATPase activityIDA
GO:0005388calcium-transporting ATPase activityIDA
GO:0005388calcium-transporting ATPase activityIMP
GO:0005509calcium ion bindingIDA
GO:0005524ATP bindingIDA
GO:0005524ATP bindingIEA
GO:0015410manganese-transporting ATPase activityIDA
GO:0030145manganese ion bindingIDA
GO:0046872metal ion bindingIEA
GeneCards ATP2C1
UniProt B4E295, B4E2Q0, P98194
Vega OTTHUMG00000136802
MIM 604384
Ensembl ENSG00000017260
HGNC 13211
HPRD 05089

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ATP2C1 gene?

The ATP2C1 gene provides instructions for making a protein called hSPCA1. This protein is an adenosine triphosphate (ATP)-powered calcium pump, which uses energy from ATP molecules to pump charged calcium atoms (calcium ions) across cell membranes. Specifically, the hSPCA1 protein transports calcium ions into a cell structure called the Golgi apparatus, where they are stored until needed. The appropriate storage and release of calcium is essential for many cell activities, including cell growth and division, cell movement, and attachment of cells to one another (cell adhesion).

The hSPCA1 protein also transports manganese ions into the Golgi apparatus. Manganese works with a variety of enzymes and is involved in processing newly formed proteins.

The hSPCA1 protein is present in cells throughout the body. It appears to be particularly important for the normal function of cells called keratinocytes, which are found in the outer layer of the skin (the epidermis).

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.