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Sequence in raw or FASTA format:

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GLRA1 glycine receptor, alpha 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu24622 NM_001292000 Homo sapiens glycine receptor, alpha 1 (GLRA1), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu26270 NM_001146040 Homo sapiens glycine receptor, alpha 1 (GLRA1), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu26374 NM_000171 Homo sapiens glycine receptor, alpha 1 (GLRA1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu39854 XM_005268412 PREDICTED: Homo sapiens glycine receptor, alpha 1 (GLRA1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu24622C NM_001292000 Homo sapiens glycine receptor, alpha 1 (GLRA1), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu26270C NM_001146040 Homo sapiens glycine receptor, alpha 1 (GLRA1), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu26374C NM_000171 Homo sapiens glycine receptor, alpha 1 (GLRA1), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu39854C XM_005268412 PREDICTED: Homo sapiens glycine receptor, alpha 1 (GLRA1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol GLRA1
Entrez Gene ID 2741
Full Name glycine receptor, alpha 1
Synonyms HKPX1, STHE
General protein information
Preferred Names
glycine receptor subunit alpha-1
Names
glycine receptor subunit alpha-1
glycine receptor 48 kDa subunit
glycine receptor strychnine-binding subunit
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q32

Summary The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
Disorder

MIM: 138491

Startle disease/hyperekplexia, autosomal dominant, 149400 (3);

mRNA Protein Product Sequence Price Select
NM_000171, 225690547 NP_000162, 119372310 glycine receptor subunit alpha-1 isoform 2 precursor ORF Sequence $360.00
NM_001146040, 225903366 NP_001139512, 225903367 glycine receptor subunit alpha-1 isoform 1 precursor ORF Sequence $550.00
NM_001292000, 635172879 NP_001278929, 635172880 glycine receptor subunit alpha-1 isoform 3 ORF Sequence $400.00
XM_005268412, 530380479 XP_005268469, 530380480 glycine receptor subunit alpha-1 isoform X2 ORF Sequence $300.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_25300Ion channel transport
REACT_25387Ligand-gated ion channel transport
Homo sapiens (human)GLRA1NP_001139512.1
Pan troglodytes (chimpanzee)GLRA1XP_001169235.1
Macaca mulatta (Rhesus monkey)GLRA1XP_002804635.1
Canis lupus familiaris (dog)GLRA1XP_003434572.1
Bos taurus (cattle)GLRA1NP_776746.1
Mus musculus (house mouse)Glra1NP_065238.2
Rattus norvegicus (Norway rat)Glra1NP_037265.1
Gallus gallus (chicken)GLRA1XP_425210.3
Danio rerio (zebrafish)glra1NP_571477.1
Drosophila melanogaster (fruit fly)GluClalphaNP_001262740.1
Caenorhabditis elegansavr-14NP_001020963.1
Caenorhabditis elegansglc-3NP_504441.1
Caenorhabditis elegansavr-15NP_001024076.1
Caenorhabditis elegansavr-15NP_001024077.1
Caenorhabditis elegansglc-1NP_507090.1
Xenopus (Silurana) tropicalis (western clawed frog)glra1XP_004912784.1
Process
IDNameEvidence
GO:0001508action potentialIEA
GO:0001964startle responseIMP
GO:0002087regulation of respiratory gaseous exchange by neurological system processIEA
GO:0006811ion transportIDA
GO:0006821chloride transportIDA
GO:0006936muscle contractionIMP
GO:0007218neuropeptide signaling pathwayIDA
GO:0007340acrosome reactionIEA
GO:0007601visual perceptionIEA
GO:0007628adult walking behaviorIEA
GO:0034220ion transmembrane transportTAS
GO:0042391regulation of membrane potentialIMP
GO:0050884neuromuscular process controlling postureIEA
GO:0051970negative regulation of transmission of nerve impulseIMP
GO:0055085transmembrane transportTAS
GO:0060012synaptic transmission, glycinergicIEA
GO:0060013righting reflexIEA
GO:0060080regulation of inhibitory postsynaptic membrane potentialIEA
GO:1902476chloride transmembrane transportIDA
GO:1902476chloride transmembrane transportIEA
GO:1902476chloride transmembrane transportIGI
GO:1902476chloride transmembrane transportIMP
GO:2000344positive regulation of acrosome reactionIMP
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIDA
GO:0005887integral component of plasma membraneIMP
GO:0005887integral component of plasma membraneNAS
GO:0009897external side of plasma membraneIEA
GO:0016021integral component of membraneNAS
GO:0030054cell junctionIEA
GO:0034707chloride channel complexIEA
GO:0043231intracellular membrane-bounded organelleIDA
GO:0045211postsynaptic membraneIEA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0016594glycine bindingIDA
GO:0016934extracellular-glycine-gated chloride channel activityIDA
GO:0016934extracellular-glycine-gated chloride channel activityIGI
GO:0016934extracellular-glycine-gated chloride channel activityIMP
GO:0022824transmitter-gated ion channel activityIEA
GO:0030977taurine bindingIDA
GeneCards GLRA1
UniProt P23415
Vega OTTHUMG00000130121
MIM 138491
Ensembl ENSG00000145888
HGNC 4326
HPRD 00719

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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